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Centre intégré universitaire de santé
et de services sociaux de l'Est-de-l'Île-de-Montréal

Centre intégré universitaire de santé et de services sociaux de l'Est-de-l'Île-de-Montréal

Luigina Mollica, M.D., Ph. D.

Luigina Mollica

Hémato-oncologue, Professeure agrégée de clinique

L'équipe de l’IHOT

Chercheur-clinicien

Contact

Tél. : 514 252-3404

En plus de sa formation médicale, Dre Luigina Mollica a obtenu un doctorat en pathologie et régulation géniques de l’Université de Londres au Royaume-Uni en 2006. Dre Mollica est une spécialiste des syndromes lymphoprolifératifs.

  • Co-gestionnaire médicale de la recherche clinique au CIUSS-de-l’Est-de-l'Ile-de-Montréal
  • Membre du Comité de priorisation clinique et recherche de l'IHOT
  • Membre du Comité d’optimisation clinique de l’IHOT
  • Membre du Comité de direction de l'IHOT
  • Chef du service d’hématologie-oncologie et thérapie cellulaire de HMR (2015-2023)
  • Entrée en poste à l’Hôpital Maisonneuve-Rosemont : 2006

 

Formation :

  • Doctorat en pathologie : Université de Londres (Angleterre), 2002-2006
  • Résidences en médecine interne, hématologie et oncologie médicale : Université de Montréal (Canada), 1996-2002 
  • Doctorat en médecine : Université de Montréal (Canada), 1991-1996
     

Découvrez ses publications

  • Interplay between hereditary and acquired factors determines the neutrophil counts in older individuals

    Marie-France Gagnon , Sylvie Provost, Maxine Sun, Sami Ayachi, Manuel Buscarlet , Luigina Mollica , Natasha Szuber , Marie-Pierre Dubé , Lambert Busque
    DOI 10.1182/bloodadvances.2022008793 PMID 36930802
    Consulter

  • Impact of Implementing a Bendamustine-Based Conditioning Regimen on Outcomes of Autologous Stem Cell Transplantation in Lymphoma while Novel Cellular Therapies Emerge

    Sylvie Lachance , Alex Bourguignon, Josie-Anne Boisjoly, Philippe Bouchard , Imran Ahmad , Nadia Bambace , Léa Bernard , Sandra Cohen , Jean-Sébastien Delisle , Isabelle Fleury , Thomas Kiss , Luigina Mollica , Denis-Claude Roy , Guy Sauvageau , Olivier Veilleux , Justine Zehr, Miguel Chagnon , Jean Roy
    DOI 10.1016/j.jtct.2022.10.003 PMID 36243319
    Consulter

  • Real-World Outcomes of Autologous and Allogeneic Hematopoietic Stem Cell Transplantation for Relapsed/Refractory Hodgkin Lymphoma in the Era of Novel Therapies: A Canadian Perspective

    Olivier Veilleux , Jean-Sébastien Claveau , Habiba Alaoui , Jean Roy , Imran Ahmad , Jean-Sébastien Delisle , Thomas Kiss , Nadia M Bambace , Léa Bernard , Sandra Cohen , Guy Sauvageau , Isabelle Fleury , Luigina Mollica , Denis-Claude Roy , Yasmina Serroukh , Sylvie Lachance
    DOI 10.1016/j.jtct.2021.12.005 PMID 34954149
    Consulter

  • Dasatinib dose optimisation based on therapeutic drug monitoring reduces pleural effusion rates in chronic myeloid leukaemia patients

    Philippe Rousselot , Luigina Mollica , Joëlle Guilhot, Agnès Guerci, Franck E. Nicolini, Gabriel Etienne, Laurence Legros, Aude Charbonnier, Valérie Coiteux, Caroline Dartigeas, Martine Escoffre-Barbe, Lydia Roy, Pascale Cony-Makhoul, Viviane Dubruille, Martine Gardembas, Françoise Huguet , Delphine Réa, Emilie Cayssials, François Guilhot, Anne Bergeron, Mathieu Molimard, Francois-Xavier Mahon, Jean-Michel Cayuela, Lambert Busque, Stéphane Bouchet
    DOI 10.1111/bjh.17654 PMID 34195988
    Consulter

  • Risk of infection in MPN patients in the era of Covid-19: A prospective multicenter study of 257 patients from the CML-MPN Quebec Research Group

    Kevin Simpson-Poirier, Michaël Harnois, Harold J Olney, Shireen Sirhan , Michel-Olivier Gratton , Sarit Assouline, Pierre Laneuville, Robert Delage , Luigina Mollica , Lambert Busque , Natasha Szuber
    DOI 10.1002/ajh.26159 PMID 33719144
    Consulter

  • Phenotypical differences and thrombosis rates in secondary erythrocytosis versus polycythemia vera

    Eliane Nguyen, Michaël Harnois , Lambert Busque , Shireen Sirhan, Sarit Assouline, Ines Chamaki, Harold Olney , Luigina Mollica , Natasha Szuber
    DOI 10.1038/s41408-021-00463-x PMID 33859172
    Consulter

  • Efficacy and safety of copanlisib in patients with relapsed or refractory marginal zone lymphoma

    Panayiotis Panayiotidis, George A Follows , Luigina Mollica , Arnon Nagler, Muhit Özcan, Armando Santoro, Don Stevens, David Trevarthen, Florian Hiemeyer, Jose Garcia-Vargas, Barrett H. Childs, Pier Luigi Zinzani, Martin Dreyling
    DOI 10.1182/bloodadvances.2020002910 PMID 33560394
    Consulter

  • Characteristics and outcomes of patients with relapsed follicular lymphoma following retreatment with second-line rituximab-containing chemotherapy

    Jiajia Liu, Douglas Stewart, Amelie Fontaine, Anthea Peters , Isabelle Fleury , Luigina Mollica , Anca Prica, Rena Buckstein, Laurie Sehn, Aixiang Jiang, John Kuruvilla, Diego Villa
    DOI 10.1080/10428194.2020.1772472 PMID 32519592
    Consulter

  • MNDA controls the expression of MCL-1 and BCL-2 in chronic lymphocytic leukemia cells

    Stefania Bottardi, Romain Guieze, Vincent Bourgoin, Nasser Fotouhi-Ardakani, Aurore Dougé, Anaïs Darracq, Yahia A Lakehal, Marc G Berger , Luigina Mollica , Jacques-Olivier Bay, James G Omichinski, Eric Milot
    DOI 10.1016/j.exphem.2020.07.004 PMID 32682001
    Consulter

  • High-sensitivity C-reactive protein is associated with clonal hematopoiesis of indeterminate potential

    Lambert Busque , Maxine Sun, Manuel Buscarlet, Sami Ayachi, Yassamin Feroz Zada, Sylvie Provost, Vincent Bourgoin , Luigina Mollica , Marlies Meisel, Reinhard Hinterleitner, Bana Jabri, Marie-Pierre Dubé, Jean-Claude Tardif
    DOI 10.1182/bloodadvances.2019000770 PMID 32492156
    Consulter

  • Long-term safety and efficacy of the PI3K inhibitor copanlisib in patients with relapsed or refractory indolent lymphoma: 2-year follow-up of the CHRONOS-1 study

    Martin Dreyling, Armando Santoro , Luigina Mollica , Sirpa Leppä, George Follows, Georg Lenz, Won Seog Kim, Arnon Nagler, Maria Dimou, Judit Demeter, Muhit Özcan, Marina Kosinova, Krimo Bouabdallah, Franck Morschhauser, Don A Stevens , David Trevarthen, Javier Munoz, Liana Rodrigues, Florian Hiemeyer, Ashok Miriyala, Jose Garcia-Vargas, Barrett H Childs, Pier Luigi Zinzani
    DOI 10.1002/ajh.25711 PMID 31868245
    Consulter

  • Evaluation of the Impact of Autologous Hematopoietic Stem Cell Transplantation on the Quality of Life of Older Patients with Lymphoma

    Christopher Lemieux , Imran Ahmad , Nadia M. Bambace , Léa Bernard , Sandra Cohen , Jean-Sébastien Delisle , Isabelle Fleury , Thomas Kiss , Luigina Mollica , Denis-Claude Roy , Guy Sauvageau , Jean Roy , Sylvie Lachance
    DOI 10.1016/j.bbmt.2019.09.007 PMID 31521818
    Consulter

  • Outcome of autologous hematopoietic stem cell transplant in older patients with B cell lymphoma when selected for fitness and chemosensitive disease

    Christopher Lemieux , Imran Ahmad , Nadia M. Bambace , Léa Bernard , Sandra Cohen , Jean-Sébastien Delisle , Isabelle Fleury , Thomas Kiss , Luigina Mollica , Denis-Claude Roy , Guy Sauvageau , Jean Roy , Sylvie Lachance
    DOI 10.1016/j.leukres.2019.01.002 PMID 30654975
    Consulter

  • Molecular monitoring of therapeutic milestones and clinical outcomes in patients with chronic myeloid leukemia

    Adi J Klil-Drori, Hui Yin, Laurent Azoulay, Alexa Del Corpo, Michaël Harnois , Michel-Olivier Gratton , Harold J Olney, Robert Delage, Pierre Laneuville , Luigina Mollica , Lambert Busque , Sarit E Assouline; Groupe Québécois de Recherche en Leucémie Myéloïde Chronique et Néoplasies Myéloprolifératives (GQR LMC-NMP)
    DOI 10.1002/cncr.31835 PMID 30423211
    Consulter

  • Concise Review: Age-Related Clonal Hematopoiesis: Stem Cells Tempting the Devil

    Lambert Busque , Manuel Buscarlet , Luigina Mollica , Ross L Levine
    DOI 10.1002/stem.2845 PMID 29883022
    Consulter

  • Lineage restriction analyses in CHIP indicate myeloid bias for TET2 and multipotent stem cell origin for DNMT3A

    Manuel Buscarlet, Sylvie Provost, Yassamin Feroz Zada, Vincent Bourgoin , Luigina Mollica , Marie-Pierre Dubé , Lambert Busque
    DOI 10.1182/blood-2018-01-829937 PMID 29764839
    Consulter

  • Early switch to second-line tyrosine kinase inhibitor in chronic myeloid leukemia patients failing to achieve early molecular response

    Adi J. Klil-Drori, Hui Yin, Laurent Azoulay, Michaël Harnois , Michel-Olivier Gratton , Alexa Del Corpo, Harold J. Olney, Robert Delage, Pierre Laneuville , Luigina Mollica , Lambert Busque , Sarit E. Assouline, On behalf of the Quebec CML Group
    DOI 10.1002/ajh.24838 PMID 28670773
    Consulter

  • Phosphatidylinositol 3-Kinase Inhibition by Copanlisib in Relapsed or Refractory Indolent Lymphoma

    Martin Dreyling, Armando Santoro , Luigina Mollica , Sirpa Leppä, George A. Follows, Georg Lenz, Won Seog Kim, Arnon Nagler, Panayiotis Panayiotidis, Judit Demeter, Muhit Özcan, Marina Kosinova, Krimo Bouabdallah, Franck Morschhauser, Don A. Stevens, David Trevarthen, Marius Giurescu, Lisa Cupit, Li Liu , Karl Köchert, Henrik Seidel, Carol Peña, Shuxin Yin, Florian Hiemeyer, Jose Garcia-Vargas, Barrett H. Childs, Pier Luigi
    DOI 10.1200/JCO.2017.75.4648 PMID 28976790
    Consulter

  • DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions

    Manuel Buscarlet, Sylvie Provost, Yassamin Feroz Zada, Amina Barhdadi, Vincent Bourgoin, Guylaine Lépine , Luigina Mollica , Natasha Szuber , Marie-Pierre Dubé , Lambert Busque
    DOI 10.1182/blood-2017-04-777029 PMID 28655780
    Consulter

  • Human blood cell levels of 5-hydroxymethylcytosine (5hmC) decline with age, partly related to acquired mutations in TET2

    Manuel Buscarlet, Alain Tessier, Sylvie Provost , Luigina Mollica , Lambert Busque
    DOI 10.1016/j.exphem.2016.07.009 PMID 27475703
    Consulter

  • Reversible lymph node follicular hyperplasia associated with dasatinib treatment of chronic myeloid leukemia in chronic phase

    Clémence Roux, Franck-Emmanuel Nicolini, Delphine Rea, Mathilde Niault , Luigina Mollica , Françoise Berger, Catherine Chassagne-Clément, Isabelle Tigaud, Michel Tulliez, Stéphane Giraudier, Ali Turhan, Philippe Rousselot, Laurence Legros
    DOI 10.1182/blood-2013-07-513879 PMID 24159167
    Consulter

  • Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

    Lambert Busque , Jay P Patel, Maria E Figueroa, Aparna Vasanthakumar, Sylvie Provost, Zineb Hamilou , Luigina Mollica , Juan Li, Agnes Viale, Adriana Heguy, Maryam Hassimi, Nicholas Socci, Parva K Bhatt, Mithat Gonen, Christopher E Mason, Ari Melnick, Lucy A Godley, Cameron W Brennan, Omar Abdel-Wahab, Ross L Levine
    DOI 10.1038/ng.2413 PMID 23001125
    Consulter

  • No association between telomere length and blood cell counts in elderly individuals

    Luigina Mollica , Isabelle Fleury , Claude Belisle, Sylvie Provost , Denis-Claude Roy , Lambert Busque
    DOI 10.1093/gerona/glp065 PMID 19435952
    Consulter

  • Skewing of X-inactivation ratios in blood cells of aging women is confirmed by independent methodologies

    Lambert Busque , Yves Paquette, Sylvie Provost , Denis-Claude Roy , Ross L Levine , Luigina Mollica , D Gary Gilliland
    DOI 10.1182/blood-2008-12-195677 PMID 19202126
    Consulter

  • Telomere length is severely and similarly reduced in JAK2V617F-positive and -negative myeloproliferative neoplasms

    Léa Bernard , C Belisle , Luigina Mollica , S Provost , Denis-Claude Roy , D G Gilliland, R L Levine , Lambert Busque
    DOI 10.1038/leu.2008.319 PMID 19005480
    Consulter

  • Hb Montreal II: a novel elongated beta-globin variant caused by a frameshift mutation [beta142 (-C)]

    Pierre Chagnon , Luigina Mollica , Claude Belisle, Céline Deveaux, Giovanni D Angelo , Denis-Claude Roy , Denis Soulières , Lambert Busque
    DOI 10.1080/03630260802173593 PMID 18654885
    Consulter

  • No evidence that skewing of X chromosome inactivation patterns is transmitted to offspring in humans

    Véronique Bolduc, Pierre Chagnon, Sylvie Provost, Marie-Pierre Dubé, Claude Belisle, Marianne Gingras , Luigina Mollica , Lambert Busque
    DOI 10.1172/JCI33166 PMID 18097474
    Consulter

  • Hypomorphic promoter mutation in PIGM causes inherited glycosylphosphatidylinositol deficiency

    Antonio M Almeida, Yoshiko Murakami, D Mark Layton, Peter Hillmen, Gabrielle S Sellick, Yusuke Maeda, Stephen Richards, Scott Patterson, Ioannis Kotsianidis , Luigina Mollica , Dorothy H Crawford, Alastair Baker, Michael Ferguson, Irene Roberts, Richard Houlston, Taroh Kinoshita, Anastasios Karadimitris
    DOI 10.1038/nm1410 PMID 16767100
    Consulter

  • Autoantibodies to thrombin directed against both of its cryptic exosites

    Luigina Mollica , Roger J S Preston, Alain Chan Kwo Chion, Steve J Lees, Peter Collins, Sarah Lewis, David A Lane
    DOI 10.1111/j.1365-2141.2005.05894.x PMID 16412021
    Consulter

  • Proteolytic inactivation of ADAMTS13 by thrombin and plasmin

    James T B Crawley, Jonathan K Lam, James B Rance , Luigina Mollica , James S O'Donnell, David A Lane
    DOI 10.1182/blood-2004-03-1101 PMID 15388580
    Consulter

  • Blockade of the apoptotic machinery by cyclosporin A redirects cell death toward necrosis in arterial endothelial cells: regulation by reactive oxygen species and cathepsin D

    Marc-André Raymond , Luigina Mollica , Normand Vigneault, Anik Désormeaux, John S D Chan, Janos G Filep, Marie-Josée Hébert
    DOI 10.1096/fj.02-0500fje PMID 12514115
    Consulter

  • Haemostatic gene polymorphisms in venous and arterial thrombosis

    David A Lane , Luigina Mollica
    DOI 10.1159/000073568 PMID 13679644
    Consulter