Passer au contenu principal
Centre intégré universitaire de santé
et de services sociaux de l'Est-de-l'Île-de-Montréal

Centre intégré universitaire de santé et de services sociaux de l'Est-de-l'Île-de-Montréal

Guy Sauvageau, M.D., Ph. D.

Guy Sauvageau

Hématologue-greffeur, Professeur titulaire

L'équipe de l’IHOT

Chercheur-clinicien

Contact

Tél. : 514 343-6111, poste 7134

Dr Guy Sauvageau est le fondateur scientifique de l’IRIC qu’il a dirigé pendant 12 ans. Il a aussi participé à la création d’IRICoR, le centre de commercialisation de la recherche de l’IRIC. Plus récemment, il a fondé et est président-directeur général ainsi que chef scientifique d’ExCellThera, responsable du développement clinique et commercial de la molécule UM171 dans un contexte de thérapie cellulaire et génique.

 

  • Directeur de l'unité de recherche en génétique moléculaire des cellules souches de l'l’Institut de recherche en immunologie et en cancérologie (IRIC) de l'Université de Montréal
  • Entrée en poste à l’Hôpital Maisonneuve-Rosemont : 1998

 

Formation :

  • Doctorat en médecine expérimentale : Université de Colombie-Britannique (Canada), 1992-1995
  • Résidences en médecine interne, hématologie et oncologie médicale : Université de Montréal (Canada), 1987-1992
  • Doctorat en médecine : Université de Montréal (Canada), 1982-1987

Découvrez ses publications

  • Comparative small molecule screening of primary human acute leukemias, engineered human leukemia and leukemia cell lines

    Safia Safa-Tahar-Henni, Karla Páez Martinez, Verena Gress, Nayeli Esparza, Élodie Roques, Florence Bonnet-Magnaval, Mélanie Bilodeau, Valérie Gagné, Eva Bresson, Sophie Cardin, Nehme El-Hachem, Isabella Iasenza, Gabriel Alzial , Isabel Boivin, Naoto Nakamichi 8, Anne-Cécile Soufflet, Cristina Mirela Pascariu, Jean Duchaine, Simon Mathien, Éric Bonneil, Kolja Eppert, Anne Marinier , Guy Sauvageau , Geneviève Deblois, Pierre Thibault , Josée Hébert , Connie J Eaves, Sonia Cellot, Frédéric Barabé, Brian T Wilhelm
    DOI 10.1038/s41375-024-02400-w PMID 39472547
    Consulter

  • UM171 enhances fitness and engraftment of gene modified hematopoietic stem cells from sickle cells disease patients

    Boya Liu, Denise Klatt, Yu Zhou, John P Manis, Guy , Guy Sauvageau , Danilo Pellin, Christian Brendel, David A Williams
    DOI 10.1182/bloodadvances.2024013932 PMID 39293082
    Consulter

  • Genetic deletion of JAM-C in pre-leukemic cells rewires leukemic stem cell gene expression program in AML

    Julien M.P. Grenier, Céline Testut, Matthieu Bal, Florence Bardin, Maria De Grandis, Véronique Gelsi-Boyer, Julien Vernerny, Marjorie C Delahaye, Samuel Granjeaud, Christophe Zemmour, Jean-François Spinella, Triantafyllos Chavakis, Stephane JC Mancini , Jean-Marie Boher , Josée Hébert , Guy Sauvageau , Norbert Vey, Juerg Schwaller, Marie-Anne Hospital, Cyril Fauriat, Michel A Aurrand-Lions
    DOI 10.1182/bloodadvances.2023011747 PMID 38954834
    Consulter

  • Protein arginine methyltransferase 2 controls inflammatory signaling in acute myeloid leukemia

    Camille Sauter, Thomas Morin, Fabien Guidez, John Simonet, Cyril Fournier, Céline Row, Denis Masnikov , Baptiste Pernon, Anne Largeot, Aziza Aznague, Yann Hérault , Guy Sauvageau , Marc Maynadié, Mary Callanan, Jean-Noël Bastie, Romain Aucagne, Laurent Delva
    DOI 10.1038/s42003-024-06453-6 PMID 38902349
    Consulter

  • Immunotherapeutic targeting of surfaceome heterogeneity in AML

    Marie-Eve Bordeleau, Éric Audemard, Arnaud Métois, Louis Theret, Véronique Lisi, Azer Farah, Jean-François Spinella, Jalila Chagraoui, Ossama Moujaber, Léo Aubert, Banafsheh Khakipoor, Laure Mallinger, Isabel Boivin, Nadine Mayotte , Azadeh Hajmirza, Éric Bonneil, François Béliveau, Sybille Pfammatter, Albert Feghaly, Geneviève Boucher, Patrick Gendron, Pierre Thibault, Frédéric Barabé, Sébastien Lemieux, Guillaume Richard-Carpentier , Josée Hébert , Vincent-Philippe Lavallée, Philippe P Roux , Guy Sauvageau
    DOI 10.1016/j.celrep.2024.114260 PMID 38838225
    Consulter

  • Near-perfect precise on-target editing of human hematopoietic stem and progenitor cells

    Fanny-Mei Cloarec-Ung, Jamie Beaulieu, Arunan Suthananthan, Bernhard Lehnertz , Guy Sauvageau , Hilary M Sheppard, David J H F Knapp
    DOI 10.7554/eLife.91288 PMID 38829685
    Consulter

  • SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia

    Céline Moison, Deanne Gracias, Julie Schmitt, Simon Girard, Jean-François Spinella, Simon Fortier, Isabel Boivin, Rodrigo Mendoza-Sanchez, Bounkham Thavonekham , Tara MacRae, Nadine Mayotte, Eric Bonneil, Mark Wittman, James Carmichael, Réjean Ruel, Pierre Thibault , Josée Hébert , Anne Marinier , Guy Sauvageau
    DOI 10.1126/sciadv.adl4018 PMID 38517966
    Consulter

  • KBTBD4-mediated reduction of MYC is critical for hematopoietic stem cell expansion upon UM171 treatment

    Jalila Chagraoui, Simon Girard, Laure Mallinger, Nadine Mayotte, Maria Florencia Tellechea , Guy Sauvageau
    DOI 10.1182/blood.2023021342 PMID 38207291
    Consulter

  • CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax and DT2216

    Verena Gress, Mathieu Roussy, Luc Boulianne, Mélanie Bilodeau, Sophie Cardin, Nehme El-Hachem, Véronique Lisi, Banafsheh Khakipoor, Alexandre Rouette, Azer Farah, Louis Théret, Léo Aubert, Furat Fatima, Éric Audemard, Pierre Thibault, Éric Bonneil , Jalila Chagraoui, Louise Laramée, Patrick Gendron, Loubna Jouan, Safa Jammali, Bastien Paré, Shawn M. Simpson, Thai Hoa Tran, Michel Duval, Pierre Teira , Henrique Bittencourt, Raoul Santiago, Frédéric Barabé , Guy Sauvageau , Martin A. Smith , Josée Hébert , Philippe P. Roux, Tanja A. Gruber, Vincent-Philippe Lavallée, Brian T. Wilhelm, Sonia Cellot
    DOI 10.1182/bloodadvances.2022008899 PMID 37729615
    Consulter

  • DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML

    Jean-François Spinella, Jalila Chagraoui, Céline Moison, Vincent P. Lavallée, Isabel Boivin, Deanne Gracias, Sylvie Lavallée, Guillaume Richard Carpentier, François Beliveau , Josée Hébert , Guy Sauvageau
    DOI 10.1038/s41375-023-02107-4 PMID 38102204
    Consulter

  • GPRC5C drives branched-chain amino acid metabolism in leukemogenesis

    Yu Wei Zhang, Talia Velasco-Hernandez, Julian Mess, Maria-Eleni Lalioti, Mari Carmen Romero-Mulero, Nadine Obier, Nikolaos Karantzelis, Jasmin Rettkowski, Katharina Schönberger , Noémie Karabacz, Karin Jäcklein, Tatsuya Morishima, Juan Luis Trincado, Paola Romecin, Alba Martinez, Hitoshi Takizawa, Khalid Shoumariyeh, Simon Renders, Robert Zeiser, Heike L. Pahl, François Béliveau , Josée Hébert , Bernhard Lehnertz , Guy Sauvageau , Pablo Menendez, Nina Cabezas-Wallscheid
    DOI 10.1182/bloodadvances.2023010460 PMID 37639313
    Consulter

  • Improved outcomes of UM171-expanded cord blood transplantation compared with other graft sources: real-world evidence

    Sandra Cohen , Nadia Bambace , Imran Ahmad , Jean Roy , Xiaoying Tang, Mei-Jie Zhang, Linda Burns, Frédéric Barabé , Léa Bernard , Jean-Sébastien Delisle , Thomas Kiss , Sylvie Lachance , Denis-Claude Roy , Olivier Veilleux , Guy Sauvageau
    DOI 10.1182/bloodadvances.2023010599 PMID 37467030
    Consulter

  • Corrigendum to' UM171 expansion of cord blood improves donor availability and HLA matching for all patients, including minorities' [Transplantation and Cellular Therapy 28/7 (2022) 410-410

    Maude Dumont-Lagacé, Albert Feghaly, Marie-Christine Meunier, Marcie Finney, Wouter Van't Hof, Emeline Masson Frenet , Guy Sauvageau , Sandra Cohen
    DOI 10.1016/j.jtct.2023.08.024 PMID 37726096
    Consulter

  • Towards clinically meaningful expansion of human HSCs

    Maria Florencia Tellechea, Jalila Chagraoui , Sandra Cohen , Guy Sauvageau
    DOI 10.1038/s41422-023-00817-z PMID 37161072
    Consulter

  • Bortezomib Maintenance After Allogeneic Transplantation in Newly Diagnosed Myeloma Patients Results in Decreased Incidence and Severity of Chronic GVHD

    Jean-Sébastien Claveau , Richard LeBlanc , Imran Ahmad , Jean-Sébastien Delisle , Sandra Cohen , Thomas Kiss , Nadia Bambace , Léa Bernard , Sylvie Lachance , Denis-Claude Roy , Guy Sauvageau , Olivier Veilleux , Jean Roy
    DOI 10.1016/j.jtct.2022.10.022 PMID 36334654
    Consulter

  • Impact of Implementing a Bendamustine-Based Conditioning Regimen on Outcomes of Autologous Stem Cell Transplantation in Lymphoma while Novel Cellular Therapies Emerge

    Sylvie Lachance , Alex Bourguignon, Josie-Anne Boisjoly, Philippe Bouchard , Imran Ahmad , Nadia Bambace , Léa Bernard , Sandra Cohen , Jean-Sébastien Delisle , Isabelle Fleury , Thomas Kiss , Luigina Mollica , Denis-Claude Roy , Guy Sauvageau , Olivier Veilleux , Justine Zehr, Miguel Chagnon , Jean Roy
    DOI 10.1016/j.jtct.2022.10.003 PMID 36243319
    Consulter

  • Unified gene expression signature of novel NPM1 exon 5 mutations in acute myeloid leukemia

    Véronique Lisi, Ève Blanchard, Michael Vladovsky, Éric Audemard, Albert Ferghaly, Sébastien Lemieux , Josée Hébert , Guy Sauvageau , Vincent-Philippe Lavallée
    DOI 10.1182/bloodadvances.2022007300 PMID 35849707
    Consulter

  • HMGA2 expression defines a subset of human AML with immature transcriptional signature and vulnerability to G2/M inhibition

    Céline Moison, Jean-François Spinella, Jalila Chagraoui, Vincent-Philippe Lavallée, Bernhard Lehnertz, Clarisse Thiollier, Isabel Boivin, Nadine Mayotte, Tara MacRae, Anne Marinier , Josée Hébert , Guy Sauvageau
    DOI 10.1182/bloodadvances.2021005828 PMID 35797243
    Consulter

  • Donor Age and Non-Relapse Mortality: Study of Their Association after HLA-Matched Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome

    Yasmine Kadri, Michelle Phan, Nadia Bambace , Léa Bernard , Sandra Cohen , Jean-Sébastien Delisle , Thomas Kiss , Sylvie Lachance , Denis-Claude Roy , Guy Sauvageau , Olivier Veilleux , Jean Roy , Imran Ahmad
    DOI 10.3390/curroncol29080470 PMID 36005208
    Consulter

  • UM171 Expansion of Cord Blood Improves Donor Availability and HLA Matching For All Patients, Including Minorities

    Maude Dumont-Lagacé, Albert Feghaly, Marie-Christine Meunier, Marcie Finney, Wouter Van't Hof, Emeline Masson Frenet , Guy Sauvageau , Sandra Cohen
    DOI 10.1016/j.jtct.2022.03.016 PMID 35311667
    Consulter

  • Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells

    Yu Wei Zhang, Julian Mess, Nadim Aizarani, Pankaj Mishra, Carys Johnson, Mari Carmen Romero-Mulero, Jasmin Rettkowski, Katharina Schönberger , Nadine Obier, Karin Jäcklein, Nadine M Woessner, Maria-Eleni Lalioti, Talia Velasco-Hernandez, Katarzyna Sikora, Ralph Wäsch, Bernhard Lehnertz , Guy Sauvageau , Thomas Manke, Pablo Menendez, Sebastian Gottfried Walter, Susana Minguet, Elisa Laurenti, Stefan Günther, Dominic Grün, Nina Cabezas-Wallscheid
    DOI 10.1038/s41556-022-00931-x PMID 35725769
    Consulter

  • CEACAM1 is a novel culture-compatible surface marker of expanded long-term reconstituting hematopoietic stem cells

    Unain Ansari, Elisa Tomellini, Jalila Chagraoui, Bernhard Lehnertz, Nadine Mayotte, Marie-Eve Bordeleau, Philippe P Roux , Guy Sauvageau
    DOI 10.1182/bloodadvances.2021006835 PMID 35286394
    Consulter

  • Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia

    Natalia Baran, Alessia Lodi, Yogesh Dhungana, Shelley Herbrich, Meghan Collins, Shannon Sweeney, Renu Pandey, Anna Skwarska, Shraddha Patel, Mathieu Tremblay , Vinitha Mary Kuruvilla, Antonio Cavazos, Mecit Kaplan, Marc O. Warmoes, Diogo Troggian Veiga, Ken Furudate, Shanti Rojas-Sutterin, Andre Haman , Yves Gareau, Anne Marinier, Helen Ma, Karine Harutyunyan, May Daher, Luciana Melo Garcia, Gheath Al-Atrash, Sujan Piya, Vivian Ruvolo, Wentao Yang, Sriram Saravanan Shanmugavelandy, Ningping Feng, Jason Gay , Di Du, Jun J. Yang, Fieke W. Hoff, Marcin Kaminski, Katarzyna Tomczak, R. Eric Davis, Daniel Herranz, Adolfo Ferrando, Elias J. Jabbour, M. Emilia Di Francesco, David T. Teachey, Terzah M. Horton, Steven Kornblau, Katayoun Rezvani , Guy Sauvageau , Mihai Gagea, Michael Andreeff, Koichi Takahashi, Joseph R. Marszalek, Philip L. Lorenzi, Jiyang Yu, Stefano Tiziani, Trang Hoang, Marina Konopleva
    DOI 10.1038/s41467-022-30396-3 PMID 35589701
    Consulter

  • CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia

    Lixiazi He, Christian Arnold, Judith Thoma, Christian Rohde, Maksim Kholmatov, Swati Garg, Cheng‐Chih Hsiao, Linda Viol, Kaiqing Zhang https://orcid.org/0000-0003-0213-6035, Rui Sun, Christina Schmidt, Maike Janssen, Tara MacRae, Karin Huber, , Josée Hébert , Guy Sauvageau , Christian Thiede , Julia Spratte, Herbert Fluhr, Gabriela Aust, Carsten Müller‐Tidow, Christof Niehrs, Gislene Pereira, Jörg Hamann, Motomu Tanaka , Judith B Zaugg, Caroline Pabst
    DOI 10.15252/emmm.202114990 PMID 35253392
    Consulter

  • Real-World Outcomes of Autologous and Allogeneic Hematopoietic Stem Cell Transplantation for Relapsed/Refractory Hodgkin Lymphoma in the Era of Novel Therapies: A Canadian Perspective

    Olivier Veilleux , Jean-Sébastien Claveau , Habiba Alaoui , Jean Roy , Imran Ahmad , Jean-Sébastien Delisle , Thomas Kiss , Nadia M Bambace , Léa Bernard , Sandra Cohen , Guy Sauvageau , Isabelle Fleury , Luigina Mollica , Denis-Claude Roy , Yasmina Serroukh , Sylvie Lachance
    DOI 10.1016/j.jtct.2021.12.005 PMID 34954149
    Consulter

  • Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia

    Jana Krosl, Marie-Eve Bordeleau, Céline Moison, Tara MacRae, Isabel Boivin, Nadine Mayotte, Deanne Gracias, Irène Baccelli, Vincent-Philippe Lavallée, Richard Bisaillon, Bernhard Lehnertz, Rodrigo Mendoza-Sanchez, Réjean Ruel, Thierry Bertomeu , Jasmin Coulombe-Huntington, Geneviève Boucher, Nandita Noronha, Caroline Pabst, Mike Tyers, Patrick Gendron, Sébastien Lemieux, Frédéric Barabé, Anne Marinier , Josée Hébert , Guy Sauvageau
    DOI 10.1182/bloodadvances.2021006047 PMID 34731885
    Consulter

  • HLF expression defines the human hematopoietic stem cell state

    Bernhard Lehnertz, Jalila Chagraoui, Tara MacRae, Elisa Tomellini, Sophie Corneau, Nadine Mayotte, Isabel Boivin, Aurélie Durand, Deanne Gracias , Guy Sauvageau
    DOI 10.1182/blood.2021010745 PMID 34499717
    Consulter

  • Outcomes in newly diagnosed young or high-risk myeloma patients receiving tandem autologous/allogeneic transplant followed by bortezomib maintenance: a phase II study

    Richard LeBlanc , Imran Ahmad , Rafik Terra, Jean-Samuel Boudreault, David Ogez, Kristopher Lamore , Jean-Sébastien Delisle , Nadia Bambace , Léa Bernard , Sandra Cohen , Thomas Kiss , Sylvie Lachance , Séverine Landais, Émilie Lemieux-Blanchard , Guy Sauvageau , Michael Sebag , Denis-Claude Roy , Jean Roy
    DOI 10.1038/s41409-021-01532-2 PMID 34845367
    Consulter

  • Legal and Ethical Considerations for the Design and Use of Web Portals for Researchers, Clinicians, and Patients: Scoping Literature Review

    Michael Lang, Sébastien Lemieux , Josée Hébert , Guy Sauvageau , Ma'n H Zawati
    DOI 10.2196/26450 PMID 34762055
    Consulter

  • A genetic screen in Drosophila uncovers the multifaceted properties of the NUP98-HOXA9 oncogene

    Gwenaëlle Gavory, Caroline Baril, Gino Laberge, Gawa Bidla, Surapong Koonpaew, Thomas Sonea , Guy Sauvageau , Marc Therrien
    DOI 10.1371/journal.pgen.1009730 PMID 34383740
    Consulter

  • Overexpression of CD200 is a Stem Cell-Specific Mechanism of Immune Evasion in AML

    Shelley Herbrich, Natalia Baran, Tianyu Cai, Connie Weng, Marisa J L Aitken, Sean M Post, Jared Henderson, Chunhua Shi, Guillame Richard-Carpentier , Guy Sauvageau , Keith Baggerly, Gheath Al-Atrash, R Eric Davis, Naval Daver, Dongxing Zha, Marina Konopleva
    DOI 10.1136/jitc-2021-002968 PMID 34326171
    Consulter

  • Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia

    Emmanuelle Supper, Saskia Rudat, Vivek Iyer, Alastair Droop, Kim Wong, Jean-François Spinella, Patrick Thomas , Guy Sauvageau , David J Adams, Chi C Wong
    DOI 10.1038/s41467-021-22750-8 PMID 33931647
    Consulter

  • Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes

    Grégory Ehx, Jean-David Larouche, Chantal Durette, Jean-Philippe Laverdure, Leslie Hesnard, Krystel Vincent, Marie-Pierre Hardy, Catherine Thériault, Caroline Rulleau, Joël Lanoix, Eric Bonneil, Albert Feghaly, Anca Apavaloaei , Nandita Noronha, Céline M Laumont , Jean-Sébastien Delisle , Luca Vago , Josée Hébert , Guy Sauvageau , Sébastien Lemieux, Pierre Thibault, Claude Perreault
    DOI 10.1016/j.immuni.2021.03.001 PMID 33740418
    Consulter

  • Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair

    Céline Moison, Jalila Chagraoui, Marie-Christine Caron, Jean-Philippe Gagné, Yan Coulombe, Guy G. Poirier, Jean-Yves Masson , Guy Sauvageau
    DOI 10.1073/pnas.2019408118 PMID 33692124
    Consulter

  • UM171-Expanded Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections

    Maude Dumont-Lagacé, Qi Li , Mégane Tanguay , Jalila Chagraoui, Tibila Kientega, Guillaume B Cardin, Ann Brasey, Assya Trofimov, Cédric Carli , Imran Ahmad , Nadia M Bambace , Léa Bernard , Thomas Kiss , Jean Roy , Denis-Claude Roy , Sébastien Lemieux, Claude Perreault, Francis Rodier, Simon Frédéric Dufresne , Lambert Busque , Sylvie Lachance , Guy Sauvageau , Sandra Cohen , Jean-Sébastien Delisle
    DOI 10.1016/j.bbmt.2020.09.031 PMID 33022376
    Consulter

  • UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex

    Jalila Chagraoui, Simon Girard, Jean-Francois Spinella, Laura Simon, Eric Bonneil, Nadine Mayotte, Tara MacRae, Jasmin Coulombe-Huntington, Thierry Bertomeu, Celine Moison, Elisa Tomellini, Pierre Thibault, Mike Tyers, Anne Marinier , Guy Sauvageau
    DOI 10.1016/j.stem.2020.12.002 PMID 33417871
    Consulter

  • Single UM171-expanded cord blood transplant can cure severe idiopathic aplastic anemia in absence of suitable donors

    Jean-Sébastien Claveau , Sandra Cohen , Imran Ahmad , Jean-Sébastien Delisle , Thomas Kiss , Sylvie Lachance , Guy Sauvageau , Lambert Busque , Rose-Marie Brito, Nadia Bambace , Léa Bernard , Denis-Claude Roy , Jean Roy
    DOI 10.1111/ejh.13504 PMID 32749758
    Consulter

  • Newly diagnosed multiple myeloma patients treated with tandem auto-allogeneic stem cell transplant have better overall survival with similar outcomes at time of relapse compared to patients who received autologous transplant only

    Richard LeBlanc , Jean-Sébastien Claveau , Imran Ahmad , Jean-Sébastien Delisle , Nadia M Bambace , Léa Bernard , Sandra Cohen , Thomas Kiss , Sylvie Lachance , Séverine Landais , Denis-Claude Roy , Guy Sauvageau , Jean Roy
    DOI 10.1111/ctr.14099 PMID 32981146
    Consulter

  • High frequency of germline RUNX1 mutations in patients with RUNX1-mutated AML

    Laura Simon, Jean-François Spinella, Chi-Yuan Yao, Vincent-Philippe Lavallée, Isabel Boivin, Geneviève Boucher, Eric Audemard, Marie-Eve Bordeleau, Sébastien Lemieux , Josée Hébert , Guy Sauvageau
    DOI 10.1182/blood.2019003357 PMID 32315381
    Consulter

  • Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1-2 safety and feasibility study

    Sandra Cohen , Jean Roy , Sylvie Lachance , Jean-Sébastien Delisle , Anne Marinier , Lambert Busque , Denis-Claude Roy , Imran Ahmad , Nadia M Bambace , Léa Bernard , Thomas Kiss , Philippe Bouchard, Pierre Caudrelier, Sévérine Landais, Fannie Larochelle, Jalila Chagraoui, Bernhard Lehnertz, Sophie Corneau, Elisa Tomellini, Jeroen J A van Kampen, Jan J Cornelissen, Maude Dumont-Lagacé, Mégane Tanguay, Qi Li , Sébastien Lemieux, Peter W Zandstra , Guy Sauvageau
    DOI 10.1016/S2352-3026(19)30202-9 PMID 31704264
    Consulter

  • Evaluation of the Impact of Autologous Hematopoietic Stem Cell Transplantation on the Quality of Life of Older Patients with Lymphoma

    Christopher Lemieux , Imran Ahmad , Nadia M. Bambace , Léa Bernard , Sandra Cohen , Jean-Sébastien Delisle , Isabelle Fleury , Thomas Kiss , Luigina Mollica , Denis-Claude Roy , Guy Sauvageau , Jean Roy , Sylvie Lachance
    DOI 10.1016/j.bbmt.2019.09.007 PMID 31521818
    Consulter

  • Genetic characterization of ABT-199 sensitivity in human AML

    Richard Bisaillon, Céline Moison, Clarisse Thiollier, Jana Krosl, Marie-Eve Bordeleau, Bernhard Lehnertz, Vincent-Philippe Lavallée, Tara MacRae, Nadine Mayotte , Caroline Labelle, Geneviève Boucher, Jean-François Spinella, Isabel Boivin, Giovanni D'Angelo, Sylvie Lavallée, Anne Marinier, Sébastien Lemieux , Josée Hébert , Guy Sauvageau
    DOI 10.1038/s41375-019-0485-x PMID 31300747
    Consulter

  • Pathways, Processes, and Candidate Drugs Associated with a Hoxa Cluster-Dependency Model of Leukemia

    Laura M Kettyle, Charles-Étienne Lebert-Ghali, Ivan V Grishagin, Glenda J Dickson, Paul G O'Reilly, David A Simpson, Janet J Bijl, Ken I Mills , Guy Sauvageau , Alexander Thompson
    DOI 10.3390/cancers11122036 PMID 31861091
    Consulter

  • Cost-Effectiveness Analysis of a HMGA2 Prognostic Test for Acute Myeloid Leukemia in a Canadian Setting

    Gabriel Tremblay, Ben Rousseau, Miriam Marquis, Cyrielle Beaubois , Guy Sauvageau , Josée Hébert
    DOI 10.1007/s40258-019-00503-5 PMID 31392669
    Consulter

  • The neuropeptide receptor calcitonin receptor-like (CALCRL) is a potential therapeutic target in acute myeloid leukemia

    Linus Angenendt, Eike Bormann, Caroline Pabst, Vijay Alla, Dennis Görlich, Leonie Braun, Kim Dohlich, Christian Schwöppe, Stefan K. Bohlander, Maria Francisca Arteaga, Klaus Wethmar, Wolfgang Hartmann , Adrian Angenendt, Torsten Kessler, Rolf M. Mesters, Matthias Stelljes, Maja Rothenberg-Thurley, Karsten Spiekermann , Josée Hébert , Guy Sauvageau , Peter J. M. Valk, Bob Löwenberg, Hubert Serve, Carsten Müller-Tidow, Georg Lenz, Bernhard J. Wörmann, M. Christina Sauerland, Wolfgang Hiddemann , Wolfgang E. Berdel, Utz Krug, Klaus H. Metzeler, Jan-Henrik Mikesch, Tobias Herold, Christoph Schliemann
    DOI 10.1038/s41375-019-0505-x PMID 31182782
    Consulter

  • UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal

    Jalila Chagraoui, Bernhard Lehnertz, Simon Girard, Jean Francois Spinella, Iman Fares, Elisa Tomellini, Nadine Mayotte, Sophie Corneau, Tara MacRae, Laura Simon , Guy Sauvageau
    DOI 10.1371/journal.pone.0224900 PMID 31703090
    Consulter

  • Allodepleted T-cell immunotherapy after haploidentical haematopoietic stem cell transplantation without severe acute graft-versus-host disease (GVHD) in the absence of GVHD prophylaxis

    Denis-Claude Roy , Sylvie Lachance , Sandra Cohen , Jean-Sébastien Delisle , Thomas Kiss , Guy Sauvageau , Lambert Busque , Imran Ahmad , Léa Bernard , Nadia M Bambace, Radia S Boumédine, Marie-Claude Guertin, Katayoun Rezvani, Stephan Mielke, Claude Perreault , Jean Roy
    DOI 10.1111/bjh.15970 PMID 31135970
    Consulter

  • A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2

    Emilie L Dubois, Laure Guitton-Sert, Mariline Béliveau, Kalindi Parmar, Jalila Chagraoui, Julien Vignard, Joris Pauty, Marie-Christine Caron, Yan Coulombe, Rémi Buisson , Karine Jacquet, Clémence Gamblin, Yuandi Gao, Patrick Laprise, Michel Lebel , Guy Sauvageau , Alan D. d’Andrea, Jean-Yves Masson
    DOI 10.1093/nar/gkz514 PMID 31219578
    Consulter

  • Targeted variant detection using unaligned RNA-Seq reads

    Eric Olivier Audemard, Patrick Gendron, Albert Feghaly, Vincent-Philippe Lavallée , Josée Hébert , Guy Sauvageau , Sébastien Lemieux
    DOI 10.26508/lsa.201900336 PMID 31427380
    Consulter

  • Integrin-α3 Is a Functional Marker of Ex Vivo Expanded Human Long-Term Hematopoietic Stem Cells

    Elisa Tomellini, Iman Fares, Bernhard Lehnertz, Jalila Chagraoui, Nadine Mayotte, Tara MacRae, Marie-Ève Bordeleau, Sophie Corneau, Richard Bisaillon , Guy Sauvageau
    DOI 10.1016/j.celrep.2019.06.084 PMID 31340144
    Consulter

  • Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML

    Swati Garg, Armando Reyes-Palomares, Lixiazi He, Anne Bergeron, Vincent-Philippe Lavallée, Sébastien Lemieux, Patrick Gendron, Christian Rohde, Jianglong Xia, Prarabdha Jagdhane, Carsten Müller-Tidow, Daniel B. Lipka, Suzan Imren, R. Keith Humphries , Claudia Waskow, Binje Vick, Irmela Jeremias, Guillaume Richard-Carpentier , Josée Hébert , Guy Sauvageau , Judith B. Zaugg, Frédéric Barabé, Caroline Pabst
    DOI 10.1182/blood.2018862383 PMID 31076446
    Consulter

  • Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia

    Irène Baccelli, Yves Gareau, Bernhard Lehnertz, Stéphane Gingras, Jean-François Spinella, Sophie Corneau, Nadine Mayotte, Simon Girard, Mélanie Frechette, Valérie Blouin-Chagnon, Koryne Leveillé, Isabel Boivin, Tara MacRae, Jana Krosl , Clarisse Thiollier, Vincent-Philippe Lavallée, Evgeny Kanshin, Thierry Bertomeu, Jasmin Coulombe-Huntington, Corinne St-Denis, Marie-Eve Bordeleau, Geneviève Boucher , Philippe P Roux, Sébastien Lemieux, Mike Tyers, Pierre Thibault , Josée Hébert , Anne Marinier , Guy Sauvageau
    DOI 10.1016/j.ccell.2019.06.003 PMID 31287994
    Consulter

  • Outcome of autologous hematopoietic stem cell transplant in older patients with B cell lymphoma when selected for fitness and chemosensitive disease

    Christopher Lemieux , Imran Ahmad , Nadia M. Bambace , Léa Bernard , Sandra Cohen , Jean-Sébastien Delisle , Isabelle Fleury , Thomas Kiss , Luigina Mollica , Denis-Claude Roy , Guy Sauvageau , Jean Roy , Sylvie Lachance
    DOI 10.1016/j.leukres.2019.01.002 PMID 30654975
    Consulter

  • Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition

    Céline Moison, Vincent-Philippe Lavallée, Clarisse Thiollier, Bernhard Lehnertz, Isabel Boivin, Nadine Mayotte, Yves Gareau, Mélanie Fréchette, Valérie Blouin-Chagnon , Sophie Corneau, Sylvie Lavallée, Sébastien Lemieux, Anne Marinier , Josée Hébert , Guy Sauvageau
    DOI 10.1182/bloodadvances.2018028480 PMID 30782614
    Consulter

  • High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia

    Miriam Marquis, Cyrielle Beaubois, Vincent-Philippe Lavallée, Michal Abrahamowicz, Coraline Danieli, Sébastien Lemieux , Imran Ahmad , Andrew Wei, Stephen B. Ting, Shaun Fleming, Anthony Schwarer, David Grimwade, William Grey, Robert K. Hills, Paresh Vyas, Nigel Russell , Guy Sauvageau , Josée Hébert
    DOI 10.1038/s41408-018-0103-6 PMID 30061630
    Consulter

  • UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells

    Mor Ngom, Suzan Imren, Tobias Maetzig, Jennifer E Adair, David J H F Knapp, Jalila Chagraoui, Iman Fares, Marie-Eve Bordeleau , Guy Sauvageau , Philippe Leboulch, Connie Eaves, Richard Keith Humphries
    DOI 10.1016/j.omtm.2018.06.009 PMID 30101153
    Consulter

  • Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin

    Vincent-Philippe Lavallée, Jalila Chagraoui, Tara MacRae, Miriam Marquis, Arnaud Bonnefoy, Jana Krosl, Sébastien Lemieux, Anne Marinier, Caroline Pabst, Georges-Étienne Rivard , Josée Hébert , Guy Sauvageau
    DOI 10.1038/s41375-018-0069-1 PMID 29550835
    Consulter

  • MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia

    Fiona C Brown, Eric Still, Richard P Koche, Christina Y Yim, Sumiko Takao, Paolo Cifani, Casie Reed, Shehana Gunasekera, Scott B Ficarro, Peter Romanienko, Willie Mark , Craig McCarthy, Elisa de Stanchina, Mithat Gonen, Venkatraman Seshan, Patrick Bhola, Conor O'Donnell, Barbara Spitzer, Crystal Stutzke, Vincent-Philippe Lavallée , Josée Hébert , Andrei V Krivtsov, Ari Melnick, Elisabeth M Paietta, Martin S Tallman, Anthony Letai , Guy Sauvageau , Gayle Pouliot, Ross Levine, Jarrod A Marto, Scott A Armstrong, Alex Kentsis
    DOI 10.1158/2159-8290.CD-17-1271 PMID 29431698
    Consulter

  • H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations

    Bernhard Lehnertz, Yu Wei Zhang, Isabel Boivin, Nadine Mayotte, Elisa Tomellini, Jalila Chagraoui, Vincent-Philippe Lavallée , Josée Hébert , Guy Sauvageau
    DOI 10.1182/blood-2017-03-774653 PMID 28855157
    Consulter

  • Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity

    Laura Simon, Vincent-Philippe Lavallée, Marie-Eve Bordeleau, Jana Krosl, Irène Baccelli, Geneviève Boucher, Bernhard Lehnertz, Jalila Chagraoui, Tara MacRae, Réjean Ruel , Yves Chantigny, Sébastien Lemieux, Anne Marinier , Josée Hébert , Guy Sauvageau
    DOI 10.1158/1078-0432.CCR-17-1259 PMID 28855357
    Consulter

  • UBAP2L is amplified in a large subset of human lung adenocarcinoma and is critical for epithelial lung cell identity and tumor metastasis

    Romain Aucagne, Simon Girard, Nadine Mayotte, Bernhard Lehnertz, Stéphane Lopes-Paciencia, Patrick Gendron, Geneviève Boucher, Jalila Chagraoui , Guy Sauvageau
    DOI 10.1096/fj.201601219RRR PMID 28754713
    Consulter

  • MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets

    Sebastien Lemieux, Tobias Sargeant, David Laperrière, Houssam Ismail, Geneviève Boucher, Marieke Rozendaal, Vincent-Philippe Lavallée, Dariel Ashton-Beaucage, Brian Wilhelm , Josée Hébert , Douglas J Hilton, Sylvie Mader , Guy Sauvageau
    DOI 10.1093/nar/gkx338 PMID 28472340
    Consulter

  • AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia

    Fengbiao Zhou, Yi Liu, Christian Rohde, Cornelius Pauli, Dennis Gerloff, Marcel Köhn, Danny Misiak, Nicole Bäumer, Chunhong Cui, Stefanie Göllner, Thomas Oellerich, Hubert Serve, Maria-Paz Garcia-Cuellar, Robert Slany , Jaroslaw P. Maciejewski, Bartlomiej Przychodzen, Barbara Seliger, Hans-Ulrich Klein, Christoph Bartenhagen, Wolfgang E. Berdel, Martin Dugas, Makoto Mark Taketo, Daneyal Farouq, Schraga Schwartz, Aviv Regev , Josée Hébert , Guy Sauvageau , Caroline Pabst, Stefan Hüttelmaier, Carsten Müller-Tidow
    DOI 10.1038/ncb3563 PMID 28650479
    Consulter

  • EPCR expression marks UM171-expanded CD34+ cord blood stem cells

    Iman Fares, Jalila Chagraoui, Bernhard Lehnertz, Tara MacRae, Nadine Mayotte, Elisa Tomellini, Léo Aubert, Philippe P Roux , Guy Sauvageau
    DOI 10.1182/blood-2016-11-750729 PMID 28408459
    Consulter

  • SMARCD2 subunit of SWI/SNF chromatin-remodeling complexes mediates granulopoiesis through a CEBPɛ dependent mechanism

    Pierre Priam, Veneta Krasteva, Philippe Rousseau, Giovanni D'Angelo, Louis Gaboury , Guy Sauvageau , Julie A Lessard
    DOI 10.1038/ng.3812 PMID 28369034
    Consulter

  • Bringing a Leukemic Stem Cell Gene Signature into Clinics: Are We There Yet?

    Guillaume Richard-Carpentier , Guy Sauvageau
    DOI 10.1016/j.stem.2017.02.010 PMID 28257710
    Consulter

  • A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens

    I Baccelli, J Krosl, G Boucher, I Boivin, V-P Lavallée , Josée Hébert , S Lemieux, A Marinier , Guy Sauvageau
    DOI 10.1038/bcj.2017.10 PMID 28211886
    Consulter

  • Distinct signaling programs control human hematopoietic stem cell survival and proliferation

    David J H F Knapp, Colin A Hammond, Nima Aghaeepour, Paul H Miller, Davide Pellacani, Philip A Beer, Karen Sachs, Wenlian Qiao, WeiJia Wang, R Keith Humphries , Guy Sauvageau , Peter W Zandstra, Sean C Bendall, Garry P Nolan, Carl Hansen, Connie J Eaves
    DOI 10.1182/blood-2016-09-740654 PMID 27827829
    Consulter

  • Human NUP98-HOXA9 promotes hyperplastic growth of hematopoietic tissues in Drosophila

    Caroline Baril, Gwenaëlle Gavory, Gawa Bidla, Helene Knævelsrud , Guy Sauvageau , Marc Therrien
    DOI 10.1016/j.ydbio.2016.11.003 PMID 27838340
    Consulter

  • High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells

    Bastien Gerby, Diogo F T Veiga, Jana Krosl, Sami Nourreddine, Julianne Ouellette, André Haman, Geneviève Lavoie, Iman Fares, Mathieu Tremblay, Véronique Litalien, Elizabeth Ottoni, Milena Kosic , Dominique Geoffrion, Joël Ryan, Paul S Maddox, Jalila Chagraoui, Anne Marinier , Josée Hébert , Guy Sauvageau , Benjamin H Kwok, Philippe P Roux, Trang Hoang
    DOI 10.1172/JCI86489 PMID 27797342
    Consulter

  • Expression of immunoproteasome genes is regulated by cell-intrinsic and -extrinsic factors in human cancers

    Alexandre Rouette, Assya Trofimov, David Haberl, Geneviève Boucher, Vincent-Philippe Lavallée, Giovanni D'Angelo , Josée Hébert , Guy Sauvageau , Sébastien Lemieux, Claude Perreault
    DOI 10.1038/srep34019 PMID 27659694
    Consulter

  • Identification of MYC mutations in acute myeloid leukemias with NUP98-NSD1 translocations

    V-P Lavallée, S Lemieux, G Boucher, P Gendron, I Boivin, S Girard , Josée Hébert , Guy Sauvageau
    DOI 10.1038/leu.2016.19 PMID 26859078
    Consulter

  • Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors

    Vincent-Philippe Lavallée, Jana Krosl, Sébastien Lemieux, Geneviève Boucher, Patrick Gendron, Caroline Pabst, Isabel Boivin, Anne Marinier, Cynthia J. Guidos, Sylvain Meloche , Josée Hébert , Guy Sauvageau
    DOI 10.1182/blood-2016-03-705053 PMID 27034432
    Consulter

  • Transcriptome analysis of G protein-coupled receptors in distinct genetic subgroups of acute myeloid leukemia: identification of potential disease-specific targets

    A Maiga, S Lemieux, C Pabst, V-P Lavallée, M Bouvier , Guy Sauvageau , Josée Hébert
    DOI 10.1038/bcj.2016.36 PMID 27258612
    Consulter

  • RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature

    Vincent-Philippe Lavallée, Sébastien Lemieux, Geneviève Boucher, Patrick Gendron, Isabel Boivin, Richard N. Armstrong , Guy Sauvageau , Josée Hébert
    DOI 10.1182/blood-2016-03-703868 PMID 26968532
    Consulter

  • GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo

    Caroline Pabst, Anne Bergeron, Vincent-Philippe Lavallée, Jonathan Yeh, Patrick Gendron, Gudmundur L. Norddahl, Jana Krosl, Isabel Boivin , Eric Deneault, Jessica Simard, Suzan Imren, Geneviève Boucher, Kolja Eppert, Tobias Herold, Stefan K. Bohlander, Keith Humphries, Sébastien Lemieux , Josée Hébert , Guy Sauvageau , Frédéric Barabé
    DOI 10.1182/blood-2015-11-683649 PMID 26834243
    Consulter

  • Favorable long-term outcome of patients with multiple myeloma using a frontline tandem approach with autologous and non-myeloablative allogeneic transplantation

    Imran Ahmad , Richard LeBlanc , Sandra Cohen , Sylvie Lachance , Thomas Kiss , Guy Sauvageau , Denis-Claude Roy , Lambert Busque , Jean-Sébastien Delisle , Nadia M Bambace , Léa Bernard , W Sabry , Jean Roy
    DOI 10.1038/bmt.2015.319 PMID 26691426
    Consulter

  • Hoxa cluster genes determine the proliferative activity of adult mouse hematopoietic stem and progenitor cells

    Charles-Étienne Lebert-Ghali, Marilaine Fournier, Laura Kettyle, Alexander Thompson , Guy Sauvageau , Janet J. Bijl
    DOI 10.1182/blood-2015-02-626390 PMID 26585953
    Consulter

  • Disclosure of incidental findings in cancer genomic research: investigators' perceptions on obligations and barriers

    E Kleiderman, D Avard, A Besso, S Ali-Khan , Guy Sauvageau , Josée Hébert
    DOI 10.1111/cge.12540 PMID 25492269
    Consulter

  • The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias

    Vincent-Philippe Lavallée, Irène Baccelli, Jana Krosl, Brian Wilhelm, Frédéric Barabé, Patrick Gendron, Geneviève Boucher, Sébastien Lemieux, Anne Marinier, Sylvain Meloche , Josée Hébert , Guy Sauvageau
    DOI 10.1038/ng.3371 PMID 26237430
    Consulter

  • Small molecule regulation of normal and leukemic stem cells

    Iman Fares, Laura Rivest-Khan , Sandra Cohen , Guy Sauvageau
    DOI 10.1097/MOH.0000000000000151 PMID 26049751
    Consulter

  • E4F1 is a master regulator of CHK1-mediated functions

    David Grote, Céline Moison, Stéphanie Duhamel, Jalila Chagraoui, Simon Girard, Jay Yang, Nadine Mayotte, Yan Coulombe, Jean-Yves Masson, Grant W Brown, Sylvain Meloche , Guy Sauvageau
    DOI 10.1016/j.celrep.2015.03.019 PMID 25843717
    Consulter

  • EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations

    Vincent-Philippe Lavallée, Patrick Gendron, Sébastien Lemieux, Giovanni D’Angelo , Josée Hébert , Guy Sauvageau
    DOI 10.1182/blood-2014-07-591529 PMID 25331116
    Consulter

  • SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells

    Bastien Gerby, Cedric S Tremblay, Mathieu Tremblay, Shanti Rojas-Sutterlin, Sabine Herblot , Josée Hébert , Guy Sauvageau , Sébastien Lemieux, Eric Lécuyer, Diogo F T Veiga, Trang Hoang
    DOI 10.1371/journal.pgen.1004768 PMID 25522233
    Consulter

  • UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity

    Marie-Eve Bordeleau, Romain Aucagne, Jalila Chagraoui, Simon Girard, Nadine Mayotte, Éric Bonneil, Pierre Thibault, Caroline Pabst, Anne Bergeron, Frédéric Barabé , Josée Hébert , Martin Sauvageau, Christel Boutonnet, Sylvain Meloche , Guy Sauvageau
    DOI 10.1182/blood-2014-01-548651 PMID 25185265
    Consulter

  • Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

    Iman Fares, Jalila Chagraoui, Yves Gareau, Stéphane Gingras, Réjean Ruel, Nadine Mayotte, Elizabeth Csaszar, David J H F Knapp, Paul Miller, Mor Ngom, Suzan Imren , Denis-Claude Roy , Kori L Watts, Hans-Peter Kiem, Robert Herrington, Norman N Iscove, R Keith Humphries, Connie J Eaves , Sandra Cohen , Anne Marinier, Peter W Zandstra , Guy Sauvageau
    DOI 10.1126/science.1256337 PMID 25237102
    Consulter

  • Epigenetic regulation of GATA2 and its impact on normal karyotype acute myeloid leukemia

    M Celton, A Forest, G Gosse, S Lemieux , Josée Hébert , Guy Sauvageau , B T Wilhelm
    DOI 10.1038/leu.2014.67 PMID 24514424
    Consulter

  • Identification of small molecules that support human leukemia stem cell activity ex vivo

    Caroline Pabst, Jana Krosl, Iman Fares, Geneviève Boucher, Réjean Ruel, Anne Marinier, Sébastien Lemieux , Josée Hébert , Guy Sauvageau
    DOI 10.1038/nmeth.2847 PMID 24562423
    Consulter

  • Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance

    Manuel Buscarlet, Veneta Krasteva, Lena Ho, Camille Simon , Josée Hébert , Brian Wilhelm, Gerald R Crabtree , Guy Sauvageau , Pierre Thibault, Julie A Lessard
    DOI 10.1182/blood-2013-02-483495 PMID 24478402
    Consulter

  • The methyltransferase G9a regulates HoxA9-dependent transcription in AML

    Bernhard Lehnertz, Caroline Pabst, Le Su, Michelle Miller, Feng Liu, Lin Yi, Regan Zhang, Jana Krosl, Eric Yung, Jeanette Kirschner, Patty Rosten, T Michael Underhill, Jian Jin , Josée Hébert , Guy Sauvageau , R Keith Humphries, Fabio M Rossi
    DOI 10.1101/gad.236794.113 PMID 24532712
    Consulter

  • Funding considerations for the disclosure of genetic incidental findings in biobank research

    L Black, D Avard, M H Zawati, B M Knoppers , Josée Hébert , Guy Sauvageau , Leucegene Project
    DOI 10.1111/cge.12190 PMID 23662709
    Consulter

  • RNA-Seq reveals spliceosome and proteasome genes as most consistent transcripts in human cancer cells

    Tara Macrae, Tobias Sargeant, Sébastien Lemieux , Josée Hébert , Eric Deneault , Guy Sauvageau
    DOI 10.1371/journal.pone.0072884 PMID 24069164
    Consulter

  • RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity

    Sonia Cellot, Kristin J Hope, Jalila Chagraoui, Martin Sauvageau, Éric Deneault, Tara MacRae, Nadine Mayotte, Brian T Wilhelm, Josette R Landry, Stephen B Ting, Jana Krosl, Keith Humphries, Alexander Thompson , Guy Sauvageau
    DOI 10.1182/blood-2013-04-496281 PMID 23777767
    Consulter

  • Entinostat prevents leukemia maintenance in a collaborating oncogene-dependent model of cytogenetically normal acute myeloid leukemia

    Joanne M Ramsey, Laura M J Kettyle, Daniel J Sharpe, Nuala M Mulgrew, Glenda J Dickson, Janet J Bijl, Pamela Austin, Nadine Mayotte, Sonia Cellot, Terence R J Lappin, Shu-Dong Zhang, Ken I Mills, Jana Krosl , Guy Sauvageau , Alexander Thompson
    DOI 10.1002/stem.1398 PMID 23592435
    Consulter

  • Identification of non-cell-autonomous networks from engineered feeder cells that enhance murine hematopoietic stem cell activity

    Eric Deneault, Brian T Wilhelm, Anne Bergeron, Frédéric Barabé , Guy Sauvageau
    DOI 10.1016/j.exphem.2013.01.003 PMID 23340137
    Consulter

  • Safety and cost-effectiveness of outpatient autologous stem cell transplantation in patients with multiple myeloma

    Andreas Holbro , Imran Ahmad , Sandra Cohen , Jean Roy , Sylvie Lachance , Miguel Chagnon , Richard LeBlanc , Léa Bernard , Lambert Busque , Denis-Claude Roy , Guy Sauvageau , Thomas Kiss
    DOI 10.1016/j.bbmt.2012.12.006 PMID 23253556
    Consulter

  • Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia

    Matthias Trost, Martin Sauvageau, Olivier Hérault, Paul Deleris, Christelle Pomiès, Jalila Chagraoui, Nadine Mayotte, Sylvain Meloche , Guy Sauvageau , Pierre Thibault
    DOI 10.1182/blood-2011-12-397844 PMID 22802335
    Consulter

  • Tandem autologous-allogeneic nonmyeloablative sibling transplantation in relapsed follicular lymphoma leads to impressive progression-free survival with minimal toxicity

    Sandra Cohen , Thomas Kiss , Sylvie Lachance , Denis-Claude Roy , Guy Sauvageau , Lambert Busque , Imran Ahmad , Jean Roy
    DOI 10.1016/j.bbmt.2011.11.028 PMID 22155507
    Consulter

  • A role for GPx3 in activity of normal and leukemia stem cells

    Olivier Herault, Kristin J Hope, Eric Deneault, Nadine Mayotte, Jalila Chagraoui, Brian T Wilhelm, Sonia Cellot, Martin Sauvageau, Miguel A Andrade-Navarro , Josée Hébert , Guy Sauvageau
    DOI 10.1084/jem.20102386 PMID 22508837
    Consulter

  • A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia

    Camille Simon, Jalila Chagraoui, Jana Krosl, Patrick Gendron, Brian Wilhelm, Sébastien Lemieux, Geneviève Boucher, Pierre Chagnon, Simon Drouin, Raphaëlle Lambert, Claude Rondeau , Annie Bilodeau, Sylvie Lavallée, Martin Sauvageau , Josée Hébert , Guy Sauvageau
    DOI 10.1101/gad.186411.111 PMID 22431509
    Consulter

  • Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2

    Stephen B Ting, Eric Deneault, Kristin Hope, Sonia Cellot, Jalila Chagraoui, Nadine Mayotte, Jonas F Dorn, Jean-Philippe Laverdure, Michael Harvey, Edwin D Hawkins, Sarah M Russell, Paul S Maddox, Norman N Iscove , Guy Sauvageau
    DOI 10.1182/blood-2011-11-393272 PMID 22174158
    Consulter

  • Cardiac tamponade potentially related to sirolimus following cord blood transplantation

    A Holbro , Imran Ahmad , Lambert Busque , Sandra Cohen , Sylvie Lachance , Denis-Claude Roy , Jean Roy , Guy Sauvageau , Thomas Kiss
    DOI 10.1038/bmt.2011.44 PMID 21399672
    Consulter

  • Incidence and prognostic value of eosinophilia in chronic graft-versus-host disease after nonmyeloablative hematopoietic cell transplantation

    Imran Ahmad , Annie-Claude Labbé, Miguel Chagnon , Lambert Busque , Sandra Cohen , Thomas Kiss , Sylvie Lachance , Denis-Claude Roy , Guy Sauvageau , Jean Roy
    DOI 10.1016/j.bbmt.2011.04.012 PMID 21601640
    Consulter

  • C-terminal domain of MEIS1 converts PKNOX1 (PREP1) into a HOXA9-collaborating oncoprotein

    Richard Bisaillon, Brian T Wilhelm, Jana Krosl , Guy Sauvageau
    DOI 10.1182/blood-2011-05-354076 PMID 21900201
    Consulter

  • Roles for MSI2 and PROX1 in hematopoietic stem cell activity

    Kristin J Hope , Guy Sauvageau
    DOI 10.1097/MOH.0b013e328347888a PMID 21577104
    Consulter

  • An anticlastogenic function for the Polycomb Group gene Bmi1

    Jalila Chagraoui , Josée Hébert , Simon Girard , Guy Sauvageau
    DOI 10.1073/pnas.1014263108 PMID 21402923
    Consulter

  • Selectively weakened binding of methotrexate by human dihydrofolate reductase allows rapid ex vivo selection of mammalian cells

    Jordan P Volpato, Nadine Mayotte, Elena Fossati, Vanessa Guerrero , Guy Sauvageau , Joelle N Pelletier
    DOI 10.1002/jmr.1037 PMID 21360609
    Consulter

  • RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity

    Brian T. Wilhelm, Mathieu Briau, Pamela Austin, Amélie Faubert, Geneviève Boucher, Pierre Chagnon, Kristin Hope, Simon Girard, Nadine Mayotte, Josette-Renee Landry , Josée Hébert , Guy Sauvageau
    DOI 10.1182/blood-2010-07-293332 PMID 20980679
    Consulter

  • Genome-wide interrogation of Mammalian stem cell fate determinants by nested chromosome deletions

    Simon Fortier, Mélanie Bilodeau, Tara Macrae, Jean-Philippe Laverdure, Valeria Azcoitia, Simon Girard, Jalila Chagraoui, Nancy Ringuette , Josée Hébert , Jana Krosl, Nadine Mayotte , Guy Sauvageau
    DOI 10.1371/journal.pgen.1001241 PMID 21170304
    Consulter

  • Late acute renal failure due to bilateral kidney infiltration by ALL as single manifestation of relapse after allogeneic transplantation

    M Detrait, C Meunier , Denis-Claude Roy , Thomas Kiss , Sylvie Lachance , Sandra Cohen , Lambert Busque , Guy Sauvageau , Jean Roy
    DOI 10.1038/bmt.2009.246 PMID 19767785
    Consulter

  • Graft-versus-host disease prophylaxis with tacrolimus and mycophenolate mofetil in HLA-matched nonmyeloablative transplant recipients is associated with very low incidence of GVHD and nonrelapse mortality

    Waleed Sabry , Richard LeBlanc , Annie-Claude Labbé , Guy Sauvageau , Stephen Couban , Thomas Kiss , Lambert Busque , Sandra Cohen , Sylvie Lachance , Denis-Claude Roy , Jean Roy
    DOI 10.1016/j.bbmt.2009.04.004 PMID 19589481
    Consulter

  • Diphyllobothriasis, a rare cause of profuse diarrhea following autologous transplantation

    M Detrait, L Poirier , Denis-Claude Roy , Thomas Kiss , Lambert Busque , Sandra Cohen , Sylvie Lachance , Guy Sauvageau , Jean Roy
    DOI 10.1038/bmt.2008.439 PMID 19169286
    Consulter

  • An automated system for delivery of an unstable transcription factor to hematopoietic stem cell cultures

    Elizabeth Csaszar, Geneviève Gavigan, Mark Ungrin, Cynthia Thérien, Pascale Dubé, James Féthière , Guy Sauvageau , Denis-Claude Roy , Peter W Zandstra
    DOI 10.1002/bit.22297 PMID 19266473
    Consulter

  • Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia

    Martin Sauvageau, Michelle Miller, Sébastien Lemieux, Julie Lessard , Josée Hébert , Guy Sauvageau
    DOI 10.1182/blood-2007-07-098236 PMID 17906077
    Consulter

  • High incidence of invasive aspergillosis associated with intestinal graft-versus-host disease following nonmyeloablative transplantation

    Annie-Claude Labbé, Shi Hann Su, Michel Laverdière, Jacques Pépin, Carlos Patiño , Sandra Cohen , Thomas Kiss , Sylvie Lachance , Guy Sauvageau , Lambert Busque , Denis-Claude Roy , Jean Roy
    DOI 10.1016/j.bbmt.2007.06.013 PMID 17889356
    Consulter

  • A retroviral strategy that efficiently creates chromosomal deletions in mammalian cells

    Mélanie Bilodeau, Simon Girard , Josée Hébert , Guy Sauvageau
    DOI 10.1038/nmeth1011 PMID 17277782
    Consulter

  • Evidence that donor intrinsic response to G-CSF is the best predictor of acute graft-vs-host disease following allogeneic peripheral blood stem cell transplantation

    Nathalie Dhédin, Inès Chamakhi, Claude Perreault , Denis-Claude Roy , Guy Sauvageau , Thierry Ducruet , Lambert Busque , Douglas Fish, Robert Bélanger , Jean Roy
    DOI 10.1016/j.exphem.2005.09.013 PMID 16413397
    Consulter

  • Oncogenic interaction between BCR-ABL and NUP98-HOXA9 demonstrated by the use of an in vitro purging culture system

    Nadine Mayotte , Denis-Claude Roy , Jing Yao, Evert Kroon , Guy Sauvageau
    DOI 10.1182/blood-2002-04-1244 PMID 12393433
    Consulter

  • Allogeneic transplantation for multiple myeloma: further evidence for a GVHD-associated graft-versus-myeloma effect

    Richard LeBlanc , S Montminy-Métivier, R Bélanger , Lambert Busque , D Fish , Denis-Claude Roy , Jeannine Kassis , J Boileau, R Lavallée, D Bélanger, F Letendre , Josée Hébert , Guy Sauvageau , C Perreault , Jean Roy
    DOI 10.1038/sj.bmt.1703253 PMID 11781644
    Consulter

  • Immunologic thrombocytopenia followed by thrombotic thrombocytopenic purpura in two HIV1 patients

    J P Routy, R Beaulieu, M Monte , Jean St-Louis , Guy Sauvageau , E Toma
    DOI 10.1002/ajh.2830380414 PMID 1746543
    Consulter