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Centre intégré universitaire de santé
et de services sociaux de l'Est-de-l'Île-de-Montréal

Centre intégré universitaire de santé et de services sociaux de l'Est-de-l'Île-de-Montréal

Lambert Busque, M.D.

Lambert Busque

Hématologue, Professeur titulaire

L'équipe de l’IHOT

Chercheur-clinicien

Contact

Tél. : 514 252-3404

Les intérêts de recherche du Dr Lambert Busque portent sur la caractérisation des causes moléculaires du développement de l’hématopoïèse clonale associée au vieillissement, l’immunothérapie du cancer et la recherche clinique en cancers myéloïdes.

 

  • Chef du service de diagnostic moléculaire clinique HMR
  • Directeur de l'unité de recherche en Hématopoïèse et vieillissement du Centre de recherche HMR
  • Membre du Comité de direction de l'IHOT
  • Président du Groupe québécois de recherche sur la LMC et les NMP (GQR-LMC/NMP)
  • Chef médical du Centre C3i (commercialisation en immunothérapie du cancer)
  • Entrée en poste à l’Hôpital Maisonneuve-Rosemont : 1994

 

Formation :

  • Fellowship en biologie moléculaire : Harvard Medical School de Boston (États-Unis), 1992-1994
  • Résidences en médecine interne et hématologie : Université de Montréal (Canada), 1986-1991
  • Doctorat en médecine : Université de Montréal (Canada), 1981-1986

Découvrez ses publications

  • CALR mutation burden in essential thrombocythemia and disease outcome

    Paola Guglielmelli , Natasha Szuber , Naseema Gangat, Giulio Capecchi, Chiara Maccari, Michaël Harnois, Omer Karrar, Maymona Abdelmagid, Manjola Balliu, Elena Nacca, Alessandro Atanasio, Ilaria Sestini, Audrey Désilets, Giuseppe Gaetano Loscocco, Giada Rotunno , Lambert Busque , Ayalew Tefferi, Alessandro Maria Vannucchi
    DOI 10.1182/blood.2023023428 PMID 38252902
    Consulter

  • Oral decitabine-cedazuridine versus intravenous decitabine for myelodysplastic syndromes and chronic myelomonocytic leukaemia (ASCERTAIN): a registrational, randomised, crossover, pharmacokinetics, phase 3 study

    Guillermo Garcia-Manero, James McCloskey, Elizabeth A Griffiths, Karen W L Yee, Amer M Zeidan, Aref Al-Kali, H Joachim Deeg, Prapti A Patel, Mitchell Sabloff, Mary-Margaret Keating , Nancy Zhu, Nashat Y Gabrail, Salman Fazal, Joseph Maly, Olatoyosi Odenike, Hagop Kantarjian, Amy E DeZern, Casey L O'Connell, Gail J Roboz , Lambert Busque , Rena Buckstein, Harshad Amin, Jasleen Randhawa, Brian Leber, Aditi Shastri, Kim-Hien Dao, Aram Oganesian, Yong Hao, Harold N Keer, Mohammad Azab, Michael R Savona
    DOI 10.1016/S2352-3026(23)00338-1 PMID 38135371
    Consulter

  • Final report of TKI discontinuation trial with dasatinib for the second attempt of treatment-free remission after failing the first attempt with imatinib: Treatment-free Remission Accomplished by Dasatinib (TRAD) study

    Maria Agustina Perusini, Igor Novitzky-Basso, Eshetu G. Atenafu, Donna Forrest, Isabelle Bence-Bruckler, Lynn Savoie, Mary-Margaret Keating , Lambert Busque , Robert Delage, Anargyros Xenocostas, Elena Liew, Pierre Laneuville, Kristjan Paulson, Tracy Stockley, Jeffrey H. Lipton, Brian Leber, Dennis Dong Hwan Kim
    DOI 10.1111/bjh.19058 PMID 37697469
    Consulter

  • Risk of progression in chronic phase-chronic myeloid leukemia patients eligible for tyrosine kinase inhibitor discontinuation: Final analysis of the TFR-PRO study

    Giovanni Paolo Maria Zambrotta, Franck E. Nicolini, Sarit Assouline , Lambert Busque , Ester Pungolino, Elisabetta Abruzzese, Maria Cristina Miggiano, Chiara Elena, Alberto Alvarez-Larran, Ana Triguero, Alessandra Iurlo, Cristina Bucelli, Marco Cerrano, Isabella Capodanno, Francesca Lunghi , Philipp le Coutre, Sara Galimberti, Giovanni Caocci, Margherita Maffioli, Fabio Stagno, Susanne Saussele, Rocco Piazza, Brian J. Druker, Carmen Fava, Veronica Guglielmana , Federica Colombo, Laura Antolini, Carlo Gambacorti-Passerini
    DOI 10.1002/ajh.27073 PMID 37647134
    Consulter

  • Canadian real-world experience of asciminib treatment in heavily pre-treated chronic myeloid leukemia (CML) patients who failed multiple lines of tyrosine kinase inhibitor (TKI) therapy

    Fatima M Khadadah, Sonia Cerquozzi, Harold J Olney, Christina Fraga, Jill Dudebout, Anargyros Xenocostas, Nicholas Finn, Vincent Ethier, M Lynn Savoie , Lambert Busque , Kareem Jamani, Philip Kuruvilla, Carolyn Faught, Brian Leber, Rayan Kaedbey, Sarit E Assouline, Dennis Kim
    DOI 10.1016/j.leukres.2023.107374 PMID 37657146
    Consulter

  • Interplay between hereditary and acquired factors determines the neutrophil counts in older individuals

    Marie-France Gagnon , Sylvie Provost, Maxine Sun, Sami Ayachi, Manuel Buscarlet , Luigina Mollica , Natasha Szuber , Marie-Pierre Dubé , Lambert Busque
    DOI 10.1182/bloodadvances.2022008793 PMID 36930802
    Consulter

  • Somatic Mosaic Chromosomal Alterations and Death of Cardiovascular Disease Causes among Cancer Survivors

    Maxine Sun, Marie-Christyne Cyr, Johanna Sandoval, Louis-Philippe Lemieux Perreault , Lambert Busque , Jean-Claude Tardif, Marie-Pierre Dubé
    DOI 10.1158/1055-9965.EPI-22-1290 PMID 36976640
    Consulter

  • Blasts in context: the impact of the immune environment on acute myeloid leukemia prognosis and treatment

    Yasmina Serroukh , Josée Hébert , Lambert Busque , François Mercier , Chris Rudd , Sarit Assouline , Sylvie Lachance , Jean-Sébastien Delisle
    DOI 10.1016/j.blre.2022.100991 PMID 35941029
    Consulter

  • Higher Rates of Perioperative Thrombosis and Distinct Management Practices in Secondary Erythrocytosis Versus Polycythemia Vera

    Natasha Szuber , Michael Harnois, Robert Delage, Shireen Sirhan , Lambert Busque
    DOI 10.1182/blood-2022-170026
    Consulter

  • Childhood maltreatment and leukocyte telomere length in men and women with chronic illness: an evaluation of moderating and mediating influences

    Alexandra Connor, Louisia Starnino , Lambert Busque , Jean-Claude Tardif, Vincent Bourgoin, Marie-Pierre Dubé, David Busseuil, Bianca D'Antono
    DOI 10.1017/S0033291722003543 PMID 36943406
    Consulter

  • Prognostic Impact of High Calreticulin Variant Allele Frequency in Patients with Myeloproliferative Neoplasms

    Audrey Desilets, Michael Harnois , Lambert Busque , Natasha Szuber
    DOI 10.1182/blood-2022-163785
    Consulter

  • A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions

    Tae-Hoon Shin, Yifan Zhou, Shirley Chen, Stefan Cordes, Max Z. Grice, Xing Fan, Byung-Chul Lee, Aisha A. Aljanahi, So Gun Hong, Kelli L. Vaughan, Julie A. Mattison, Steven G. Kohama, Margarete A. Fabre, Naoya Uchida , Selami Demirci, Marcus A. F. Corat, Jean-Yves Métais, Katherine R. Calvo, Manuel Buscarlet, Hannah Natanson, Kathy L. McGraw, Alan F. List , Lambert Busque , John F. Tisdale, George S. Vassiliou, Kyung-Rok Yu, Cynthia E. Dunbar
    DOI 10.1182/blood.2021014875 PMID 35714307
    Consulter

  • Combined PD-L1 and TIM3 blockade improves expansion of fit human CD8+ antigen-specific T cells for adoptive immunotherapy

    Shirin Lak, Valérie Janelle, Anissa Djedid, Gabrielle Boudreau, Ann Brasey, Véronique Lisi, Ali Smaani, Cédric Carli , Lambert Busque , Vincent-Philippe Lavallée , Jean-Sébastien Delisle
    DOI 10.1016/j.omtm.2022.09.016 PMID 36320412
    Consulter

  • Perioperative management of myeloproliferative neoplasms: A pan-Canadian physician survey and international expert opinion

    Natasha Szuber , Panagiota Toliopoulos , Lambert Busque , Sonia Cerquozzi, Lynda Foltz, Vikas Gupta, Ayalew Tefferi, Alessandro Maria Vannucchi, Christopher Hillis, Brian Leber, Dawn Maze, Jaroslav Prchal, Harold J. Olney, Shireen Sirhan
    DOI 10.1002/ajh.26739 PMID 36151067
    Consulter

  • Two types of human TCR differentially regulate reactivity to self and non-self antigens

    Assya Trofimov, Philippe Brouillard, Jean-David Larouche, Jonathan Séguin, Jean-Philippe Laverdure, Ann Brasey, Gregory Ehx , Denis-Claude Roy , Lambert Busque , Sylvie Lachance , Sébastien Lemieux, Claude Perreault
    DOI 10.1016/j.isci.2022.104968 PMID 36111255
    Consulter

  • The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms

    Joseph D. Khoury, Eric Solary, Oussama Abla, Yassmine Akkari, Rita Alaggio, Jane F. Apperley, Rafael Bejar, Emilio Berti , Lambert Busque , John K. C. Chan, Weina Chen, Xueyan Chen, Wee-Joo Chng, John K. Choi, Isabel Colmenero, Sarah E. Coupland, Nicholas C. P. Cross, Daphne De Jong, M. Tarek Elghetany, Emiko Takahashi, Jean-Francois Emile, Judith Ferry, Linda Fogelstrand, Michaela Fontenay, , Ulrich Germing, Sumeet Gujral, Torsten Haferlach, Claire Harrison, Jennelle C. Hodge, Shimin Hu, Joop H. Jansen, Rashmi Kanagal-Shamanna, Hagop M. Kantarjian, Christian P. Kratz, Xiao-Qiu Li, Megan S. Lim, Keith Loeb , Sanam Loghavi, Andrea Marcogliese, Soheil Meshinchi, Phillip Michaels, Kikkeri N. Naresh, Yasodha Natkunam, Reza Nejati, German Ott, Eric Padron, Keyur P. Patel, Nikhil Patkar, Jennifer Picarsic, Uwe Platzbecker , Irene Roberts, Anna Schuh, William Sewell, Reiner Siebert, Prashant Tembhare, Jeffrey Tyner, Srdan Verstovsek, Wei Wang, Brent Wood, Wenbin Xiao, Cecilia Yeung, Andreas Hochhaus
    DOI 10.1038/s41375-022-01613-1 PMID 35732831
    Consulter

  • Natural spring water gargle samples as an alternative to nasopharyngeal swabs for SARS-CoV-2 detection using a laboratory-developed test

    Sarah Gobeille Paré, Julie Bestman-Smith, Judith Fafard, Florence Doualla-Bell, Mariève Jacob-Wagner, Christian Lavallée, Hugues Charest, Stéphanie Beauchemin, François Coutlée, Jeannot Dumaresq , Lambert Busque , Manon St-Hilaire, Guylaine Lépine, Valérie Bouche, Marc Desforges, Isabelle Goupil-Sormany, Annie-Claude Labbé; G-SPIT study group
    DOI 10.1002/jmv.27407 PMID 34672374
    Consulter

  • Acute central nervous system graft-versus-host-disease after liver transplantation

    Valérie Massey, Véronique Martel, Dang Khoa Nguyen , Lambert Busque , Hugo Chapdelaine, Mark Robert Keezer
    DOI 10.1016/j.trim.2021.101521 PMID 34952167
    Consulter

  • BCR-ABL1 transcript doubling time as a predictor for treatment-free remission failure after imatinib discontinuation in chronic myeloid leukaemia in chronic phase

    Dennis Dong Hwan Kim, Taehyung Simon Kim, Eshetu G. Atenafu, Igor Novitzky Basso, Donna Forrest, Isabelle Bence-Bruckler, Lynn Savoie , Lambert Busque , Mary-Margaret Keating, Robert Delage, Anargyros Xenocostas, Elena Liew, Kristjan Paulson, Tracy Stockley, Pierre Laneuville, Jeffrey H. Lipton, Suzanne Kamel-Reid, Brian Leber
    DOI 10.1111/bjh.17807 PMID 34496035
    Consulter

  • The safety and efficacy of dasatinib plus nivolumab in patients with previously treated chronic myeloid leukemia: results from a phase 1b dose-escalation study

    Joaquín Martínez-López, Satu Mustjoki, Kimmo Porkka, Rebecca B Klisovic, Dominik Wolf , Lambert Busque , Juan Carlos Hernández-Boluda, Rene Swanink, Patricia Martin Regueira, Jeffrey H Lipton
    DOI 10.1080/10428194.2021.1889536 PMID 33653205
    Consulter

  • Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial

    Jean-Claude Tardif, Nadia Bouabdallaoui, Philippe L L'Allier, Daniel Gaudet, Binita Shah, Michael H Pillinger, Jose Lopez-Sendon, Protasio da Luz, Lucie Verret, Sylvia Audet , Jocelyn Dupuis, André Denault, Martin Pelletier, Philippe A Tessier, Sarah Samson, Denis Fortin, Jean-Daniel Tardif, David Busseuil, Elisabeth Goulet, Chantal Lacoste , Anick Dubois, Avni Y Joshi, David D Waters, Priscilla Hsue, Norman E Lepor, Frédéric Lesage, Nicolas Sainturet, Eve Roy-Clavel, Zohar Bassevitch, Andreas Orfanos, Gabriela Stamatescu, Jean C Grégoire , Lambert Busque , Christian Lavallée, Pierre-Olivier Hétu, Jean-Sébastien Paquette, Spyridon G Deftereos, Sylvie Levesque, Mariève Cossette, Anna Nozza, Malorie Chabot-Blanchet, Marie-Pierre Dubé, Marie-Claude Guertin, Guy Boivin; COLCORONA Investigators
    DOI 10.1016/S2213-2600(21)00222-8 PMID 34051877
    Consulter

  • Risk of infection in MPN patients in the era of Covid-19: A prospective multicenter study of 257 patients from the CML-MPN Quebec Research Group

    Kevin Simpson-Poirier, Michaël Harnois, Harold J Olney, Shireen Sirhan , Michel-Olivier Gratton , Sarit Assouline, Pierre Laneuville, Robert Delage , Luigina Mollica , Lambert Busque , Natasha Szuber
    DOI 10.1002/ajh.26159 PMID 33719144
    Consulter

  • Optimal duration of imatinib treatment/deep molecular response for treatment-free remission after imatinib discontinuation from a Canadian tyrosine kinase inhibitor discontinuation trial

    Dennis D. H. Kim, Igor Novitzky-Basso, Taehyung S. Kim, Eshetu G. Atenafu, Donna Forrest, Lynn Savoie, Isabelle Bence-Bruckler, Mary-Margaret Keating , Lambert Busque , Robert Delage, Anargyros Xenocostas, Elena Liew, Kristjan Paulson, Tracy Stockley, Pierre Laneuville, Jeffrey H. Lipton, Suzanne Kamel-Reid, Brian Leber
    DOI 10.1111/bjh.17447 PMID 33876423
    Consulter

  • Phenotypical differences and thrombosis rates in secondary erythrocytosis versus polycythemia vera

    Eliane Nguyen, Michaël Harnois , Lambert Busque , Shireen Sirhan, Sarit Assouline, Ines Chamaki, Harold Olney , Luigina Mollica , Natasha Szuber
    DOI 10.1038/s41408-021-00463-x PMID 33859172
    Consulter

  • UM171-Expanded Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections

    Maude Dumont-Lagacé, Qi Li , Mégane Tanguay , Jalila Chagraoui, Tibila Kientega, Guillaume B Cardin, Ann Brasey, Assya Trofimov, Cédric Carli , Imran Ahmad , Nadia M Bambace , Léa Bernard , Thomas Kiss , Jean Roy , Denis-Claude Roy , Sébastien Lemieux, Claude Perreault, Francis Rodier, Simon Frédéric Dufresne , Lambert Busque , Sylvie Lachance , Guy Sauvageau , Sandra Cohen , Jean-Sébastien Delisle
    DOI 10.1016/j.bbmt.2020.09.031 PMID 33022376
    Consulter

  • The associations of hostility and defensiveness with telomere length are influenced by sex and health status

    Louisia Starnino, Gilles Dupuis , Lambert Busque , Vincent Bourgoin, Marie-Pierre Dubé, David Busseuil, Bianca D'Antono
    DOI 10.1186/s13293-020-00349-w PMID 33397445
    Consulter

  • Single UM171-expanded cord blood transplant can cure severe idiopathic aplastic anemia in absence of suitable donors

    Jean-Sébastien Claveau , Sandra Cohen , Imran Ahmad , Jean-Sébastien Delisle , Thomas Kiss , Sylvie Lachance , Guy Sauvageau , Lambert Busque , Rose-Marie Brito, Nadia Bambace , Léa Bernard , Denis-Claude Roy , Jean Roy
    DOI 10.1111/ejh.13504 PMID 32749758
    Consulter

  • Correction: Imatinib mesylate inhibits STAT5 phosphorylation in response to IL-7 and promotes T cell lymphopenia in chronic myelogenous leukemia patients

    S Thiant, M M Moutuou, P Laflamme, R Sidi Boumedine, D M Leboeuf , Lambert Busque , Jean Roy , M Guimond
    DOI 10.1038/s41408-020-00374-3 PMID 33149116
    Consulter

  • Oral cedazuridine/decitabine for MDS and CMML: a phase 2 pharmacokinetic/pharmacodynamic randomized crossover study

    Guillermo Garcia-Manero, Elizabeth A. Griffiths, David P. Steensma, Gail J. Roboz, Richard Wells, James McCloskey, II, Olatoyosi Odenike, Amy E. DeZern, Karen Yee , Lambert Busque , Casey O’Connell, Laura C. Michaelis, Joseph Brandwein, Hagop Kantarjian, Aram Oganesian, Mohammad Azab, Michael R. Savona
    DOI 10.1182/blood.2019004143 PMID 32285126
    Consulter

  • High-sensitivity C-reactive protein is associated with clonal hematopoiesis of indeterminate potential

    Lambert Busque , Maxine Sun, Manuel Buscarlet, Sami Ayachi, Yassamin Feroz Zada, Sylvie Provost, Vincent Bourgoin , Luigina Mollica , Marlies Meisel, Reinhard Hinterleitner, Bana Jabri, Marie-Pierre Dubé, Jean-Claude Tardif
    DOI 10.1182/bloodadvances.2019000770 PMID 32492156
    Consulter

  • 60 Years of clonal hematopoiesis research: From X-chromosome inactivation studies to the identification of driver mutations

    Sami Ayachi, Manuel Buscarlet , Lambert Busque
    DOI 10.1016/j.exphem.2020.01.008 PMID 32001340
    Consulter

  • Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1-2 safety and feasibility study

    Sandra Cohen , Jean Roy , Sylvie Lachance , Jean-Sébastien Delisle , Anne Marinier , Lambert Busque , Denis-Claude Roy , Imran Ahmad , Nadia M Bambace , Léa Bernard , Thomas Kiss , Philippe Bouchard, Pierre Caudrelier, Sévérine Landais, Fannie Larochelle, Jalila Chagraoui, Bernhard Lehnertz, Sophie Corneau, Elisa Tomellini, Jeroen J A van Kampen, Jan J Cornelissen, Maude Dumont-Lagacé, Mégane Tanguay, Qi Li , Sébastien Lemieux, Peter W Zandstra , Guy Sauvageau
    DOI 10.1016/S2352-3026(19)30202-9 PMID 31704264
    Consulter

  • The predictive value of intracellular imatinib levels in newly diagnosed chronic myeloid leukemia

    Christopher M. Hillis, Nicholas L. Jackson Chornenki, Isabelle Bence-Bruckler , Lambert Busque , Yvan Cote, Caroline Hamm, Wanda Hasegawa, Suzanne Kamel-Reid, Lynn Savoie, A. Robert Turner, Anargyros Xenocostas, Jeffrey H. Lipton, Brian Leber
    DOI 10.1016/j.leukres.2019.106285 PMID 31846781
    Consulter

  • Allodepleted T-cell immunotherapy after haploidentical haematopoietic stem cell transplantation without severe acute graft-versus-host disease (GVHD) in the absence of GVHD prophylaxis

    Denis-Claude Roy , Sylvie Lachance , Sandra Cohen , Jean-Sébastien Delisle , Thomas Kiss , Guy Sauvageau , Lambert Busque , Imran Ahmad , Léa Bernard , Nadia M Bambace, Radia S Boumédine, Marie-Claude Guertin, Katayoun Rezvani, Stephan Mielke, Claude Perreault , Jean Roy
    DOI 10.1111/bjh.15970 PMID 31135970
    Consulter

  • Persistence with generic imatinib for chronic myeloid leukemia: a matched cohort study

    Adi J. Klil-Drori Hui Yin Laurent Azoulay Michaël Harnois , Michel-Olivier Gratton , Lambert Busque , Sarit E Assouline, Groupe Québécois de Recherche en Leucémie Myéloïde Chronique et Néoplasies Myéloprolifératives (GQR LMC-NMP)
    DOI 10.3324/haematol.2018.211235 PMID 30630987
    Consulter

  • 3023 Mayo Clinic Patients With Myeloproliferative Neoplasms: Risk-Stratified Comparison of Survival and Outcomes Data Among Disease Subgroups

    Natasha Szuber , Mythri Mudireddy, Maura Nicolosi, Domenico Penna, Rangit R Vallapureddy, Terra L Lasho, Christy Finke, Kebede H Begna, Michelle A Elliott, C Christopher Hook, Alexandra P Wolanskyj, Mrinal M Patnaik, Curtis A Hanson , Rhett P Ketterling, Shireen Sirhan, Animesh Pardanani, Naseema Gangat , Lambert Busque , Ayalew Tefferi
    DOI 10.1016/j.mayocp.2018.08.022 PMID 30824279
    Consulter

  • Molecular monitoring of therapeutic milestones and clinical outcomes in patients with chronic myeloid leukemia

    Adi J Klil-Drori, Hui Yin, Laurent Azoulay, Alexa Del Corpo, Michaël Harnois , Michel-Olivier Gratton , Harold J Olney, Robert Delage, Pierre Laneuville , Luigina Mollica , Lambert Busque , Sarit E Assouline; Groupe Québécois de Recherche en Leucémie Myéloïde Chronique et Néoplasies Myéloprolifératives (GQR LMC-NMP)
    DOI 10.1002/cncr.31835 PMID 30423211
    Consulter

  • MBD4: guardian of the epigenetic galaxy

    Lambert Busque , Lucy A Godley
    DOI 10.1182/blood-2018-08-867044 PMID 30287469
    Consulter

  • Concise Review: Age-Related Clonal Hematopoiesis: Stem Cells Tempting the Devil

    Lambert Busque , Manuel Buscarlet , Luigina Mollica , Ross L Levine
    DOI 10.1002/stem.2845 PMID 29883022
    Consulter

  • Lineage restriction analyses in CHIP indicate myeloid bias for TET2 and multipotent stem cell origin for DNMT3A

    Manuel Buscarlet, Sylvie Provost, Yassamin Feroz Zada, Vincent Bourgoin , Luigina Mollica , Marie-Pierre Dubé , Lambert Busque
    DOI 10.1182/blood-2018-01-829937 PMID 29764839
    Consulter

  • Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host

    Marlies Meisel, Reinhard Hinterleitner, Alain Pacis, Li Chen, Zachary M. Earley, Toufic Mayassi, Joseph F. Pierre, Jordan D. Ernest, Heather J. Galipeau, Nikolaus Thuille, Romain Bouziat, Manuel Buscarlet, Daina L. Ringus , Yitang Wang, Ye Li, Vu Dinh, Sangman M. Kim, Benjamin D. McDonald, Matthew A. Zurenski, Mark W. Musch, Glaucia C. Furtado, Sergio A. Lira, Gottfried Baier, Eugene B. Chang, A. Murat Eren, Christopher R. Weber , Lambert Busque , Lucy A. Godley, Elena F. Verdú, Luis B. Barreiro, Bana Jabri
    DOI 10.1038/s41586-018-0125-z PMID 29769727
    Consulter

  • Rationale, design, and preliminary results of the Quebec Warfarin Cohort Study

    Sylvie Perreault, Payman Shahabi, Robert Côté, Stéphanie Dumas, Étienne Rouleau-Mailloux, Yassamin Feroz Zada, Sylvie Provost, Ian Mongrain, Marc Dorais, Thao Huynh, Simon Kouz, Ariel Diaz , Mark Blostein, Simon de Denus, Jacques Turgeon, Jeffrey Ginsberg, Jacques Lelorier, Lyne Lalonde , Lambert Busque , Jeannine Kassis , Mario Talajic, Jean-Claude Tardif, Marie-Pierre Dubé
    DOI 10.1002/clc.22948 PMID 29542828
    Consulter

  • Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies

    Robert L Bowman , Lambert Busque , Ross L Levine
    DOI 10.1016/j.stem.2018.01.011 PMID 29395053
    Consulter

  • Identification of the genetic determinants responsible for retinal degeneration in families of Mexican descent

    Adda Villanueva, Pooja Biswas, Kameron Kishaba, John Suk, Keerti Tadimeti, Pongali B Raghavendra, Karine Nadeau , Bruno Lamontagne , Lambert Busque , Steve Geoffroy, Ian Mongrain, Géraldine Asselin, Sylvie Provost, Marie-Pierre Dubé, Eric Nudleman, Radha Ayyagari
    DOI 10.1080/13816810.2017.1373830 PMID 28945494
    Consulter

  • Clinical-Scale Rapid Autologous BK Virus-Specific T Cell Line Generation From Kidney Transplant Recipients With Active Viremia for Adoptive Immunotherapy

    Caroline Lamarche, Julie Orio, Victoria Georges-Tobar, Thomas Pincez, Mathieu Goupil, Amina Dahmani, Cedric Carli, Ann Brasey , Lambert Busque , Jean-Sébastien Delisle
    DOI 10.1097/TP.0000000000001698 PMID 28230645
    Consulter

  • Early switch to second-line tyrosine kinase inhibitor in chronic myeloid leukemia patients failing to achieve early molecular response

    Adi J. Klil-Drori, Hui Yin, Laurent Azoulay, Michaël Harnois , Michel-Olivier Gratton , Alexa Del Corpo, Harold J. Olney, Robert Delage, Pierre Laneuville , Luigina Mollica , Lambert Busque , Sarit E. Assouline, On behalf of the Quebec CML Group
    DOI 10.1002/ajh.24838 PMID 28670773
    Consulter

  • DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions

    Manuel Buscarlet, Sylvie Provost, Yassamin Feroz Zada, Amina Barhdadi, Vincent Bourgoin, Guylaine Lépine , Luigina Mollica , Natasha Szuber , Marie-Pierre Dubé , Lambert Busque
    DOI 10.1182/blood-2017-04-777029 PMID 28655780
    Consulter

  • Imatinib mesylate inhibits STAT5 phosphorylation in response to IL-7 and promotes T cell lymphopenia in chronic myelogenous leukemia patients

    S Thiant, M M Moutuou, P Laflamme, R Sidi Boumedine, D M Leboeuf , Lambert Busque , Jean Roy , M Guimond
    DOI 10.1038/bcj.2017.29 PMID 28387753
    Consulter

  • HSPCs are marathon and not sprint relay athletes

    Lambert Busque
    DOI 10.1182/blood-2017-02-763516 PMID 28302687
    Consulter

  • Human blood cell levels of 5-hydroxymethylcytosine (5hmC) decline with age, partly related to acquired mutations in TET2

    Manuel Buscarlet, Alain Tessier, Sylvie Provost , Luigina Mollica , Lambert Busque
    DOI 10.1016/j.exphem.2016.07.009 PMID 27475703
    Consulter

  • Psychological Profiles in the Prediction of Leukocyte Telomere Length in Healthy Individuals

    Louisia Starnino , Lambert Busque , Jean-Claude Tardif, Bianca D'Antono
    DOI 10.1371/journal.pone.0165482 PMID 27788238
    Consulter

  • Laboratory Investigation of Myeloproliferative Neoplasms (MPNs): Recommendations of the Canadian Mpn Group

    Lambert Busque , Anna Porwit, Radmila Day, Harold J Olney, Brian Leber, Vincent Éthier, Shireen Sirhan, Linda Foltz, Jaroslav Prchal, Suzanne Kamel-Reid, Aly Karsan, Vikas Gupta
    DOI 10.1093/ajcp/aqw131 PMID 27686169
    Consulter

  • Novel germline mutations in the calreticulin gene: implications for the diagnosis of myeloproliferative neoplasms

    Natasha Szuber , Bruno Lamontagne , Lambert Busque
    DOI 10.1136/jclinpath-2016-203940 PMID 27466382
    Consulter

  • Evaluating the Impact of a Switch to Nilotinib on Imatinib-Related Chronic Low-Grade Adverse Events in Patients With CML-CP: The ENRICH Study

    Jorge E Cortes, Jeffrey H Lipton, Carole B Miller , Lambert Busque , Luke P Akard, Javier Pinilla-Ibarz, Christopher Keir, Ghulam Warsi, Felice P Lin, Michael J Mauro
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