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Centre intégré universitaire de santé
et de services sociaux de l'Est-de-l'Île-de-Montréal

Centre intégré universitaire de santé et de services sociaux de l'Est-de-l'Île-de-Montréal

Sylvie Lesage, Ph. D.

Sylvie Lesage

Directrice scientifique du Centre de recherche HMR, Professeure titulaire

L'équipe de l’IHOT

Chercheur

Contact

Tél. : 514 252-3400, poste 4649

Sylvie Lesage est professeure titulaire au Département de microbiologie, infectiologie et immunologie de la Faculté de médecine de l’Université de Montréal. Les principaux intérêts de recherche de Prof. Lesage portent sur plusieurs types de cellules du système immunitaire et leur impact sur des maladies génétiques complexes comme les maladies auto-immunes et le cancer.

 

  • Chercheur de mérite FRQS
  • Directrice de l'unité de recherche en Immunogénétique cellulaire du Centre de recherche HMR
  • Membre du comité de direction de l’IHOT
  • Entrée en poste à l'Hôpital Maisonneuve-Rosemont : 2005

 

Formation :

  • Stage postdoctoral : Université nationale d’Australie, 1999 à 2002
  • Doctorat en médecine expérimentale de l'Université McGill au Canada, 1995-1999

Découvrez ses publications

  • Exploratory analyses of leukocyte responses in hospitalized patients treated with ozanimod following a severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection

    Olivier Courtemanche, Pascale Blais-Lecours , Sylvie Lesage , Geneviève Chabot-Roy, Lise Coderre, Marie-Renée Blanchet, Nathalie Châteauvert, François Lellouche, David Marsolais
    DOI 10.1111/imcb.70006 PMID 40025871
    Consulter

  • Prolonging neutrophil room temperature storage with clinically-approved solutions: Implications for granulocyte transfusion

    Labrecque MM, Allard ME, Murru A, Paré G, Acker JP , Sylvie Lesage
    DOI 10.1093/jleuko/qiae258 PMID 39716952
    Consulter

  • Prolonging neutrophil room temperature storage with clinically-approved solutions: Implications for granulocyte transfusion

    Marie-Michèle Labrecque, Marie-Ève Allard, Andréa Murru, Guillaume Paré, Jason P Acker , Sylvie Lesage , Mélissa Girard, Maria J Fernandes
    DOI 10.1093/jleuko/qiae258 PMID 39716952
    Consulter

  • Characterization and effective expansion of CD4-CD8- TCRαβ+ T cells from individuals living with type 1 diabetes

    J Ernesto Fajardo-Despaigne, Félix Lombard-Vadnais, Adam-Nicolas Pelletier, Aïnhoa Olazabal, Lucie Boutin, Sarah Pasquin, Valérie Janelle, Laurent Legault , Jean-Sébastien Delisle , Erin E Hillhouse, Lise Coderre , Sylvie Lesage
    DOI 10.1016/j.omtm.2024.101400 PMID 39877593
    Consulter

  • NOD alleles at Idd1 and Idd2 loci drive exocrine pancreatic inflammation

    Laurence Caron, Daria Vdovenko, Félix Lombard-Vadnais , Sylvie Lesage
    DOI 10.1007/s00251-024-01352-w PMID 39207501
    Consulter

  • Variations in the germinal center response revealed by genetically diverse mouse strains

    Anne-Marie Aubin, Daria Vdovenko, Roxanne Collin, Lois Balmer, Lise Coderre, Grant Morahan, Félix Lombard-Vadnais , Sylvie Lesage
    DOI 10.1111/imcb.12823 PMID 39318030
    Consulter

  • The Long-Acting Glucagon-Like Peptide-2 Analog Apraglutide Enhances Intestinal Protection and Survival After Chemotherapy and Allogeneic Transplantation in Mice

    Mark D Minden, Cindy Audiger, Geneviève Chabot-Roy , Sylvie Lesage , Jean-Sébastien Delisle , Barbara Biemans, Violetta Dimitriadou
    DOI 10.12659/AOT.945249 PMID 39497378
    Consulter

  • Highlight of 2023: Thymic B cells-important players in the establishment of T-cell tolerance

    Félix Lombard-Vadnais , Sylvie Lesage
    DOI 10.1111/imcb.12761 PMID 38650472
    Consulter

  • Highlight of 2023: From fundamental studies to clinical trials, the importance of NK cells against cancer

    Capucine Bourel , Sylvie Lesage
    DOI 10.1111/imcb.12763 PMID 38670548
    Consulter

  • Detection of CLCF1 protein expression by flow cytometry

    Véronique Laplante, Marine Rousseau, Félix Lombard-Vadnais, Ulysse Nadeau, Agathe Nazha, Jean-François Schmouth, Mukut Sharma , Sylvie Lesage , Jean-François Gauchat, Sarah Pasquin
    DOI 10.1038/s41598-024-64101-9 PMID 38858477
    Consulter

  • A genetic mouse model of lean-NAFLD unveils sexual dimorphism in the liver-heart axis

    Charlotte Burelle, Valentin Clapatiuc, Sonia Deschênes, Alexanne Cuillerier, Marine De Loof, Marie-Ève Higgins, Hugues Boël, Caroline Daneault, Billie Chouinard , Marie-Élaine Clavet, Nolwenn Tessier, Isabelle Croteau, Geneviève Chabot, Catherine Martel, Martin G Sirois , Sylvie Lesage , Yan Burelle, Matthieu Ruiz
    DOI 10.1038/s42003-024-06035-6 PMID 38519536
    Consulter

  • Modified host defence peptide GF19 slows TNT-mediated spread of corneal herpes simplex virus serotype I infection

    Neethi C Thathapudi, Natalia Callai-Silva, Kamal Malhotra, Sankar Basu, Mozhgan Aghajanzadeh-Kiyaseh, Mostafa Zamani-Roudbaraki, Marc Groleau, Félix Lombard-Vadnais , Sylvie Lesage , May Griffith
    DOI 10.1038/s41598-024-53662-4 PMID 38374240
    Consulter

  • Armstrong strain lymphocytic choriomeningitis virus infection after accidental laboratory exposure

    Laurence Caron , Jean-Sébastien Delisle , James E Strong, Yvon Deschambault, Félix Lombard-Vadnais, Annie-Claude Labbé , Sylvie Lesage
    DOI 10.1186/s12985-023-02258-x PMID 38087355
    Consulter

  • Association of low-density neutrophils with lung function and disease progression in adult cystic fibrosis

    Andréa Murru, Nathalie Vadeboncoeur, Andrée-Anne Therrien, Lise Coderre, Myriam Vaillancourt, Marie-Michèle Labrecque, Yves Berthiaume, Guillaume Bouvet , Damien Adam, Emmanuelle Brochiero , Sylvie Lesage , Nicolas Flamand, Lara Bilodeau, Maria J Fernandes
    DOI 10.1016/j.jcf.2023.03.009 PMID 36973151
    Consulter

  • Uncoupling of Natural Killer cell functional maturation and cytolytic function in NOD mice

    Capucine Bourel, Victor Mullins-Dansereau, Maher Al Khaldi, Geneviève Chabot-Roy, Félix Lombard-Vadnais , Sylvie Lesage
    DOI 10.1111/imcb.12676 PMID 37536708
    Consulter

  • Serum Lipidomic Screen Identifies Key Metabolites, Pathways, and Disease Classifiers in Crohn's Disease

    Romain Ferru-Clément, Gabrielle Boucher, Anik Forest, Bertrand Bouchard, Alain Bitton , Sylvie Lesage , Phil Schumm, Mark Lazarev, Steve Brant, Richard H Duerr, Dermot P B McGovern, Mark Silverberg, Judy H Cho; NIDDK IBD Genetics Consortium, iGenoMed Consortium; Ashwin Ananthakrishnan , Ramnik J Xavier, John D Rioux, Christine Des Rosiers
    DOI 10.1093/ibd/izac281 PMID 36662167
    Consulter

  • Phosphorylcholine and KR12-Containing Corneal Implants in HSV-1-Infected Rabbit Corneas

    Kamal Malhotra, Oleksiy Buznyk, Mohammad Mirazul Islam, Elle Edin, Sankar Basu, Marc Groleau, Delali Shana Dégué, Per Fagerholm, Adrien Fois , Sylvie Lesage , Jaganmohan R Jangamreddy, Egidijus Šimoliūnas, Aneta Liszka, Hirak K Patra, May Griffith
    DOI 10.3390/pharmaceutics15061658 PMID 37376106
    Consulter

  • Immature and mature bone marrow-derived dendritic cells exhibit distinct intracellular mechanical properties

    Antoine Leblanc-Hotte, Cindy Audiger, Geneviève Chabot-Roy, Félix Lombard-Vadnais , Jean-Sébastien Delisle , Yves-Alain Peter , Sylvie Lesage
    DOI 10.1038/s41598-023-28625-w PMID 36737470
    Consulter

  • Identifying transcript-level differential expression in primary human immune cells

    Saraï Mola, Claudine Beauchamp, Gabrielle Boucher , Sylvie Lesage , Mohamad Karaky, Philippe Goyette, Sylvain Foisy, John D Rioux
    DOI 10.1016/j.molimm.2022.12.005 PMID 36527757
    Consulter

  • Activation-induced cytidine deaminase expression by thymic B cells promotes T-cell tolerance and limits autoimmunity

    Félix Lombard-Vadnais, Geneviève Chabot-Roy, Astrid Zahn, Sahily Rodriguez Torres, Javier M Di Noia, Heather J Melichar , Sylvie Lesage
    DOI 10.1016/j.isci.2022.105852 PMID 36654860
    Consulter

  • Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits

    Carly E Whyte, Kailash Singh, Oliver T Burton, Meryem Aloulou, Lubna Kouser, Rafael Valente Veiga, Amy Dashwood, Hanneke Okkenhaug, Samira Benadda , Alena Moudra, Orian Bricard, Stephanie Lienart, Pascal Bielefeld, Carlos P Roca, Francisco José Naranjo-Galindo, Félix Lombard-Vadnais, Steffie Junius, David Bending , Masahiro Ono, Tino Hochepied, Timotheus Y F Halim, Susan Schlenner , Sylvie Lesage , James Dooley, Adrian Liston
    DOI 10.1084/jem.20212391 PMID 35699942
    Consulter

  • OCA-B does not act as a transcriptional coactivator in T cells

    Félix Lombard-Vadnais, Julie Lacombe, Geneviève Chabot-Roy, Mathieu Ferron , Sylvie Lesage
    DOI 10.1111/imcb.12543 PMID 35285071
    Consulter

  • The NOD Mouse Beyond Autoimmune Diabetes

    Anne-Marie Aubin, Félix Lombard-Vadnais, Roxanne Collin, Holly A Aliesky, Sandra M McLachlan , Sylvie Lesage
    DOI 10.3389/fimmu.2022.874769 PMID 35572553
    Consulter

  • The Idd2 Locus Confers Prominent Resistance to Autoimmune Diabetes

    Félix Lombard-Vadnais, Roxanne Collin, Jean-François Daudelin, Geneviève Chabot-Roy, Nathalie Labrecque , Sylvie Lesage
    DOI 10.4049/jimmunol.2100456 PMID 35039332
    Consulter

  • Serum Analyte Profiles Associated With Crohn's Disease and Disease Location

    Gabrielle Boucher, Alexandre Paradis, Geneviève Chabot-Roy, Lise Coderre, Erin E Hillhouse, Alain Bitton, Christine Des Rosiers, Megan K Levings, L Philip Schumm , Mark Lazarev, Steve R Brant, Richard Duerr, Dermot McGovern, Mark S Silverberg, Judy Cho , Sylvie Lesage , John D Rioux; iGenoMed Consortium; NIDDK IBD Genetics Consortium
    DOI 10.1093/ibd/izab123 PMID 34106269
    Consulter

  • Evidence of genetic epistasis in autoimmune diabetes susceptibility revealed by mouse congenic sublines

    Roxanne Collin, Véronique Dugas, Adam-Nicolas Pelletier, Geneviève Chabot-Roy , Sylvie Lesage
    DOI 10.1007/s00251-021-01214-9 PMID 33755757
    Consulter

  • Starting Your Independent Research Laboratory

    Adrian Liston , Sylvie Lesage
    DOI 10.1161/STROKEAHA.121.035333 PMID 34107733
    Consulter

  • The Potential Causes of Cystic Fibrosis-Related Diabetes

    Lise Coderre, Lyna Debieche, Joëlle Plourde , Rémi Rabasa-Lhoret , Sylvie Lesage
    DOI 10.3389/fendo.2021.702823 PMID 34394004
    Consulter

  • CD5 levels reveal distinct basal T-cell receptor signals in T cells from non-obese diabetic mice

    Mengqi Dong, Cindy Audiger, Adeolu Adegoke, Marie-Ève Lebel, Stefanie F Valbon, Colin C Anderson, Heather J Melichar , Sylvie Lesage
    DOI 10.1111/imcb.12443 PMID 33534942
    Consulter

  • Applying for Junior Faculty Positions as a Research Scientist

    Sylvie Lesage , Adrian Liston
    DOI 10.1161/STROKEAHA.121.035332 PMID 34082574
    Consulter

  • Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs

    Fiona C Simpson, Christopher D McTiernan, Mohammad Mirazul Islam, Oleksiy Buznyk, Philip N Lewis, Keith M Meek, Michel Haagdorens, Cindy Audiger , Sylvie Lesage , François-Xavier Gueriot, Isabelle Brunette, Marie-Claude Robert, David Olsen, Laura Koivusalo, Aneta Liszka, Per Fagerholm, Miguel Gonzalez-Andrades, May Griffith
    DOI 10.1038/s42003-021-02108-y PMID 34021240
    Consulter

  • Upregulated IL-32 Expression And Reduced Gut Short Chain Fatty Acid Caproic Acid in People Living With HIV With Subclinical Atherosclerosis

    Mohamed El-Far, Madeleine Durand, Isabelle Turcotte, Etienne Larouche-Anctil, Mohamed Sylla, Sarah Zaidan, Carl Chartrand-Lefebvre, Rémi Bunet, Hardik Ramani, Manel Sadouni, Irina Boldeanu, Annie Chamberland , Sylvie Lesage , Jean-Guy Baril, Benoit Trottier, Réjean Thomas, Emmanuel Gonzalez, Ali Filali-Mouhim, Jean-Philippe Goulet, Jeffrey A Martinson, Seble Kassaye, Roksana Karim , Jorge R Kizer, Audrey L French, Stephen J Gange, Petronela Ancuta, Jean-Pierre Routy, David B Hanna, Robert C Kaplan, Nicolas Chomont, Alan L Landay, Cécile L Tremblay
    DOI 10.3389/fimmu.2021.664371 PMID 33936102
    Consulter

  • LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy

    Delphine Planas, Amélie Pagliuzza, Rosalie Ponte, Augustine Fert, Laurence Raymond Marchand, Marta Massanella, Annie Gosselin, Vikram Mehraj, Franck P Dupuy, Stéphane Isnard, Jean-Philippe Goulet , Sylvie Lesage , Eric A Cohen, Mager Peter Ghali, Jonathan B Angel, Nicolas Chomont, Jean-Pierre Routy, Petronela Ancuta
    DOI 10.1016/j.ebiom.2021.103270 PMID 33662832
    Consulter

  • Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis

    Charlotte Girondel, Kim Lévesque, Marie-Josée Langlois, Sarah Pasquin, Marc K Saba-El-Leil, Nathalie Rivard, Robert Friesel, Marc J Servant, Jean-François Gauchat , Sylvie Lesage , Sylvain Meloche
    DOI 10.1038/s41388-020-01540-4 PMID 33177649
    Consulter

  • Humoral responses to the measles, mumps and rubella vaccine are impaired in Leigh Syndrome French Canadian patients

    Adrien Fois, Anne-Marie Boucher-Lafleur, Julie Thompson Legault, Christian Renaud, Charles Morin, Christine Des Rosiers, Lise Coderre, Catherine Laprise , Sylvie Lesage , LSFC Consortium
    DOI 10.1371/journal.pone.0239860 PMID 33085679
    Consulter

  • FLT3 Ligand Is Dispensable for the Final Stage of Type 1 Conventional Dendritic Cell Differentiation

    Cindy Audiger , Sylvie Lesage
    DOI 10.4049/jimmunol.2000742 PMID 32887750
    Consulter

  • Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia

    Guoyue Xu, Rebekah van Bruggen, Christian O Gualtieri, Neda Moradin, Adrien Fois, Diane Vallerand, Mariana De Sa Tavares Russo, Angelia Bassenden, Wenyun Lu, Mifong Tam , Sylvie Lesage , Hélène Girouard, Daina Zofija Avizonis, Geneviève Deblois, Josef T Prchal, Mary Stevenson, Albert Berghuis, Tom Muir, Joshua Rabinowitz , Silvia M Vidal, Nassima Fodil, Philippe Gros
    DOI 10.1016/j.celrep.2020.108170 PMID 32966787
    Consulter

  • Merocytic Dendritic Cells Compose a Conventional Dendritic Cell Subset with Low Metabolic Activity

    Cindy Audiger, Adrien Fois, Alyssa L Thomas, Edith Janssen, Martin Pelletier , Sylvie Lesage
    DOI 10.4049/jimmunol.1900970 PMID 32461238
    Consulter

  • MHC-Independent Thymic Selection of CD4 and CD8 Coreceptor Negative αβ T Cells

    Roxanne Collin 1 2, Félix Lombard-Vadnais, Erin E Hillhouse, Marie-Ève Lebel, Geneviève Chabot-Roy, Heather J Melichar , Sylvie Lesage
    DOI 10.4049/jimmunol.2000156 PMID 32434937
    Consulter

  • A transcriptome-based approach to identify functional modules within and across primary human immune cells

    Saraï Mola, Sylvain Foisy, Gabrielle Boucher, François Major, Claudine Beauchamp, Mohamad Karaky, Philippe Goyette , Sylvie Lesage , John D Rioux
    DOI 10.1371/journal.pone.0233543 PMID 32469933
    Consulter

  • BMP9 signaling promotes the normalization of tumor blood vessels

    Claire Viallard, Cindy Audiger, Natalija Popovic, Naoufal Akla, Kevin Lanthier, Isaac Legault-Navarrete, Heather Melichar, Santiago Costantino , Sylvie Lesage , Bruno Larrivée
    DOI 10.1038/s41388-020-1200-0 PMID 32042114
    Consulter

  • Flt3L-Mediated Expansion of Plasmacytoid Dendritic Cells Suppresses HIV Infection in Humanized Mice

    Tram N Q Pham, Oussama Meziane, Mohammad Alam Miah, Olga Volodina, Chloé Colas, Kathie Béland, Yuanyi Li, Frédéric Dallaire, Tibor Keler, Jean V Guimond , Sylvie Lesage , Cheolho Cheong, Élie Haddad, Éric A Cohen
    DOI 10.1016/j.celrep.2019.10.094 PMID 31775044
    Consulter

  • Glycolipid Stimulation of Invariant NKT Cells Expands a Unique Tissue-Resident Population of Precursors to Mature NK Cells Endowed with Oncolytic and Antimetastatic Properties

    Joshua Choi, Patrick T Rudak , Sylvie Lesage , S M Mansour Haeryfar
    DOI 10.4049/jimmunol.1900487 PMID 31462506
    Consulter

  • Induced and spontaneous colitis mouse models reveal complex interactions between IL-10 and IL-12/IL-23 pathways

    Raphaël Hurtubise, Cindy Audiger, Maria C Dominguez-Punaro, Geneviève Chabot-Roy, Gaëlle Chognard, Laurence Raymond-Marchand, Lise Coderre, Sylvain Chemtob , Stephen W Michnick, John D Rioux , Sylvie Lesage
    DOI 10.1016/j.cyto.2019.154738 PMID 31158699
    Consulter

  • The orphan nuclear receptor NR4A3 controls the differentiation of monocyte-derived dendritic cells following microbial stimulation

    Salix Boulet, Jean-François Daudelin, Livia Odagiu, Adam-Nicolas Pelletier, Tae Jin Yun , Sylvie Lesage , Cheolho Cheong, Nathalie Labrecque
    DOI 10.1073/pnas.1821296116 PMID 31285338
    Consulter

  • Common Heritable Immunological Variations Revealed in Genetically Diverse Inbred Mouse Strains of the Collaborative Cross

    Roxanne Collin, Lois Balmer, Grant Morahan , Sylvie Lesage
    DOI 10.4049/jimmunol.1801247 PMID 30587532
    Consulter

  • On-chip refractive index cytometry for whole-cell deformability discrimination

    Antoine Leblanc-Hotte, Nadine Sen Nkwe, Geneviève Chabot-Roy, El Bachir Affar , Sylvie Lesage , Jean-Sébastien Delisle , Yves-Alain Peter
    DOI 10.1039/c8lc00938d PMID 30570636
    Consulter

  • Double-Negative T Cell Levels Correlate with Chronic Graft-versus-Host Disease Severity

    Erin E Hillhouse, Stéphanie Thiant, Moutuaata M Moutuou, Félix Lombard-Vadnais, Rachel Parat , Jean-Sébastien Delisle , Imran Ahmad , Denis-Claude Roy , Martin Guimond , Jean Roy , Sylvie Lesage
    DOI 10.1016/j.bbmt.2018.09.008 PMID 30244108
    Consulter

  • BIM determines the number of merocytic dendritic cells, a cell type that breaks immune tolerance

    Cindy Audiger , Sylvie Lesage
    DOI 10.1111/imcb.12165 PMID 29754432
    Consulter

  • Abnormal differentiation of B cells and megakaryocytes in patients with Roifman syndrome

    Jessica Heremans, Josselyn E Garcia-Perez, Ernest Turro, Susan M Schlenner, Ingele Casteels, Roxanne Collin, Francis de Zegher, Daniel Greene, Stephanie Humblet-Baron , Sylvie Lesage , Patrick Matthys, Christopher J Penkett, Karen Put, Kathleen Stirrups; National Institute for Health Research BioResource; Chantal Thys, Chris Van Geet, Erika Van Nieuwenhove, Carine Wouters, Isabelle Meyts , Kathleen Freson, Adrian Liston
    DOI 10.1016/j.jaci.2017.11.061 PMID 29391254
    Consulter

  • Genetic interaction between two insulin-dependent diabetes susceptibility loci, Idd2 and Idd13, in determining immunoregulatory DN T cell proportion

    Roxanne Collin, Kathy Doyon, Victor Mullins-Dansereau, Martin Karam , Geneviève Chabot-Roy, Erin E Hillhouse, Alexandre Orthwein , Sylvie Lesage
    DOI 10.1007/s00251-018-1060-8 PMID 29696366
    Consulter

  • High-throughput refractive index-based microphotonic sensor for enhanced cellular discrimination

    Antoine Leblanc-Hotte, Geneviève Chabot-Roy, Livia Odagiu, Manon Richaud , Sylvie Lesage , Jean-Sébastien Delisle , Yves-Alain Peter
    DOI 10.1016/j.snb.2018.03.087
    Consulter

  • Restoring T Cell Homeostasis After Allogeneic Stem Cell Transplantation; Principal Limitations and Future Challenges

    Moutuaata M Moutuou, Gabriel Pagé, Intesar Zaid , Sylvie Lesage , Martin Guimond
    DOI 10.3389/fimmu.2018.01237 PMID 29967605
    Consulter

  • Biomarker-guided stratification of autoimmune patients for biologic therapy

    Sabine Ivison, Christine Des Rosiers , Sylvie Lesage , John D Rioux, Megan K Levings
    DOI 10.1016/j.coi.2017.09.006 PMID 29053992
    Consulter

  • An orthologous non-MHC locus in rats and mice is linked to CD4+ and CD8+ T-cell proportion

    D Franckaert, R Collin, J Dooley, R H Wallis, P Poussier, A Liston, E E Hillhouse , Sylvie Lesage
    DOI 10.1038/gene.2017.9 PMID 28539651
    Consulter

  • An Unbiased Linkage Approach Reveals That the p53 Pathway Is Coupled to NK Cell Maturation

    Roxanne Collin, Charles St-Pierre, Lorie Guilbault, Victor Mullins-Dansereau, Antonia Policheni, Fanny Guimont-Desrochers , Adam-Nicolas Pelletier, Daniel H Gray, Elliot Drobetsky, Claude Perreault, Erin E Hillhouse , Sylvie Lesage
    DOI 10.4049/jimmunol.1600789 PMID 28710252
    Consulter

  • High-level intrathymic thyrotrophin receptor expression in thyroiditis-prone mice protects against the spontaneous generation of pathogenic thyrotrophin receptor autoantibodies

    S M McLachlan, H A Aliesky, B Banuelos , Sylvie Lesage , R Collin, B Rapoport
    DOI 10.1111/cei.12928 PMID 28099999
    Consulter

  • Mechanism of insulin resistance in a rat model of kidney disease and the risk of developing type 2 diabetes

    François Dion, Christopher Dumayne, Nathalie Henley, Stéphanie Beauchemin, Edward B Arias, François A Leblond , Sylvie Lesage , Stéphane Lefrançois, Gregory D Cartee, Vincent Pichette
    DOI 10.1371/journal.pone.0176650 PMID 28459862
    Consulter

  • Genes Outside the Major Histocompatibility Complex Locus Are Linked to the Development of Thyroid Autoantibodies and Thyroiditis in NOD.H2h4 Mice

    Sandra M McLachlan , Sylvie Lesage , Roxanne Collin, Bianca Banuelos, Holly A Aliesky, Basil Rapoport
    DOI 10.1210/en.2016-1875 PMID 28323998
    Consulter

  • The Importance of Dendritic Cells in Maintaining Immune Tolerance

    Cindy Audiger, M Jubayer Rahman, Tae Jin Yun, Kristin V Tarbell , Sylvie Lesage
    DOI 10.4049/jimmunol.1601629 PMID 28264998
    Consulter

  • MARCH1 E3 Ubiquitin Ligase Dampens the Innate Inflammatory Response by Modulating Monocyte Functions in Mice

    Tristan Galbas, Maxime Raymond, Antoine Sabourin, Marie-Claude Bourgeois-Daigneault, Fanny Guimont-Desrochers, Tae Jin Yun, Jean-François Cailhier, Satoshi Ishido , Sylvie Lesage , Cheolho Cheong, Jacques Thibodeau
    DOI 10.4049/jimmunol.1601168 PMID 27940660
    Consulter

  • Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry

    Benoîte Bourdin, Emilie Segura, Marie-Philippe Tétreault , Sylvie Lesage , Lucie Parent
    DOI 10.3791/54732 PMID 27768059
    Consulter

  • TCR transgenic mice reveal the impact of type 1 diabetes loci on early and late disease checkpoints

    Erin E Hillhouse, Adrian Liston, Roxanne Collin, Eric Desautels, Christopher C Goodnow , Sylvie Lesage
    DOI 10.1038/icb.2016.27 PMID 27046082
    Consulter

  • The Importance of Single-Mode Behavior in Silicon-On-Insulator Rib Waveguides With Very Large Cross Section for Resonant Sensing Applications

    Antoine Leblanc-Hotte , Jean-Sébastien Delisle , Sylvie Lesage , Yves-Alain Peter
    DOI 10.1109/JSTQE.2016.2545634
    Consulter

  • IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking

    Durga Sivanesan, Claudine Beauchamp, Christiane Quinou, Jonathan Lee , Sylvie Lesage , Sylvain Chemtob, John D Rioux, Stephen W Michnick
    DOI 10.1074/jbc.M116.715870 PMID 26887945
    Consulter

  • Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

    James Dooley, Lei Tian, Susann Schonefeldt, Viviane Delghingaro-Augusto, Josselyn E Garcia-Perez, Emanuela Pasciuto, Daniele Di Marino, Edward J Carr, Nikolay Oskolkov, Valeriya Lyssenko , Dean Franckaert, Vasiliki Lagou, Lut Overbergh, Jonathan Vandenbussche, Joke Allemeersch, Genevieve Chabot-Roy, Jane E Dahlstrom, D Ross Laybutt, Nikolai Petrovsky, Luis Socha, Kris Gevaert, Anton M Jetten , Diether Lambrechts, Michelle A Linterman, Chris C Goodnow, Christopher J Nolan , Sylvie Lesage , Susan M Schlenner, Adrian Liston
    DOI 10.1038/ng.3531 PMID 26998692
    Consulter

  • NK Cell Proportion and Number Are Influenced by Genetic Loci on Chromosomes 8, 9, and 17

    Adam-Nicolas Pelletier, Lorie Guilbault, Fanny Guimont-Desrochers, Erin E Hillhouse , Sylvie Lesage
    DOI 10.4049/jimmunol.1502284 PMID 26851217
    Consulter

  • Identification of Glycosylation Sites Essential for Surface Expression of the CaVα2δ1 Subunit and Modulation of the Cardiac CaV1.2 Channel Activity

    Marie-Philippe Tétreault, Benoîte Bourdin, Julie Briot, Emilie Segura , Sylvie Lesage , Céline Fiset, Lucie Parent
    DOI 10.1074/jbc.M115.692178 PMID 26742847
    Consulter

  • Evidence that MHC I-E dampens thyroid autoantibodies and prevents spreading to a second thyroid autoantigen in I-Ak NOD mice

    Adam-Nicolas Pelletier, Holly A Aliesky, Bianca Banuelos, Geneviève Chabot-Roy, Basil Rapoport , Sylvie Lesage , Sandra M McLachlan
    DOI 10.1038/gene.2015.7 PMID 25811933
    Consulter

  • Autoimmunity and antibody affinity maturation are modulated by genetic variants on mouse chromosome 12

    Roxanne Collin, Véronique Dugas, Geneviève Chabot-Roy, David Salem, Astrid Zahn, Javier M Di Noia, Joyce Rauch , Sylvie Lesage
    DOI 10.1016/j.jaut.2015.01.007 PMID 25623266
    Consulter

  • Functional characterization of CaVα2δ mutations associated with sudden cardiac death

    Benoîte Bourdin, Behzad Shakeri, Marie-Philippe Tétreault, Rémy Sauvé , Sylvie Lesage , Lucie Parent
    DOI 10.1074/jbc.M114.597930 PMID 25527503
    Consulter

  • Specific targeting of the IL-23 receptor, using a novel small peptide noncompetitive antagonist, decreases the inflammatory response

    Christiane Quiniou, Maria Domínguez-Punaro, Frank Cloutier, Atefeh Erfani, Jamila Ennaciri, Durgajini Sivanesan, Mélanie Sanchez, Gaëlle Chognard, Xin Hou , José Carlos Rivera, Claudine Beauchamp, Guy Charron, Marie Vilquin, Vijay Kuchroo, Stephen Michnick, John D Rioux , Sylvie Lesage , Sylvain Chemtob
    DOI 10.1152/ajpregu.00540.2013 PMID 25354400
    Consulter

  • The mouse idd2 locus is linked to the proportion of immunoregulatory double-negative T cells, a trait associated with autoimmune diabetes resistance

    Roxanne Collin, Véronique Dugas, Adam-Nicolas Pelletier, Geneviève Chabot-Roy , Sylvie Lesage
    DOI 10.4049/jimmunol.1400189 PMID 25165153
    Consulter

  • A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction

    Owen M Siggs, Adèle L Yates, Susan Schlenner, Adrian Liston , Sylvie Lesage , Christopher C Goodnow
    DOI 10.1111/imm.12220 PMID 24266404
    Consulter

  • Idd13 is involved in determining immunoregulatory DN T-cell number in NOD mice

    V Dugas, A Liston, E E Hillhouse, R Collin, G Chabot-Roy, A-N Pelletier, C Beauchamp, K Hardy , Sylvie Lesage
    DOI 10.1038/gene.2013.65 PMID 24335706
    Consulter

  • The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation

    Gaëlle Chognard, Lisa Bellemare, Adam-Nicolas Pelletier, Maria C Dominguez-Punaro, Claudine Beauchamp, Marie-Josée Guyon, Guy Charron, Nicolas Morin, Durga Sivanesan , Vijay Kuchroo, Ramnik Xavier, Stephen W Michnick, Sylvain Chemtob, John D Rioux , Sylvie Lesage
    DOI 10.1371/journal.pone.0089092 PMID 24586521
    Consulter

  • Revisiting the Prominent Anti-Tumoral Potential of Pre-mNK Cells

    Fanny Guimont-Desrochers , Sylvie Lesage
    DOI 10.3389/fimmu.2013.00446 PMID 24376447
    Consulter

  • The Idd13 congenic interval defines the number of merocytic dendritic cells, a novel trait associated with autoimmune diabetes susceptibility

    Adam-Nicolas Pelletier , Sylvie Lesage
    DOI 10.1016/j.jaut.2013.04.004 PMID 23623717
    Consulter

  • Unusual selection and peripheral homeostasis for immunoregulatory CD4(-) CD8(-) T cells

    Véronique Dugas, Geneviève Chabot-Roy, Claudine Beauchamp, Fanny Guimont-Desrochers, Erin E Hillhouse, Adrian Liston , Sylvie Lesage
    DOI 10.1111/imm.12064 PMID 23293940
    Consulter

  • Nearby Construction Impedes the Progression to Overt Autoimmune Diabetes in NOD Mice

    Erin E Hillhouse, Roxanne Collin, Geneviève Chabot-Roy, Marie-Josée Guyon, Nathalie Tessier, Maryse Boulay, Patricia Liscourt , Sylvie Lesage
    DOI 10.1155/2013/620313 PMID 23691516
    Consulter

  • A comprehensive review of the phenotype and function of antigen-specific immunoregulatory double negative T cells

    Erin E Hillhouse , Sylvie Lesage
    DOI 10.1016/j.jaut.2012.07.010 PMID 22910322
    Consulter

  • Immunoregulatory CD4(-)CD8(-) T cells as a potential therapeutic tool for transplantation, autoimmunity, and cancer

    Erin E Hillhouse , Jean-Sébastien Delisle , Sylvie Lesage
    DOI 10.3389/fimmu.2013.00006 PMID 23355840
    Consulter

  • The size of the plasmacytoid dendritic cell compartment is a multigenic trait dominated by a locus on mouse chromosome 7

    Adam-Nicolas Pelletier, Fanny Guimont-Desrochers, Michelle P Ashton, Thomas C Brodnicki , Sylvie Lesage
    DOI 10.4049/jimmunol.1102136 PMID 22547694
    Consulter

  • Redefining interferon-producing killer dendritic cells as a novel intermediate in NK-cell differentiation

    Fanny Guimont-Desrochers, Geneviève Boucher, Zhongjun Dong, Martine Dupuis, André Veillette , Sylvie Lesage
    DOI 10.1182/blood-2011-11-395954 PMID 22353997
    Consulter

  • Molecular and genetic parameters defining T-cell clonal selection

    Nathalie Labrecque, Troy Baldwin , Sylvie Lesage
    DOI 10.1038/icb.2010.119 PMID 20956988
    Consulter

  • Implication of the CD47 pathway in autoimmune diabetes

    Véronique Dugas, Claudine Beauchamp, Geneviève Chabot-Roy, Erin E Hillhouse , Sylvie Lesage
    DOI 10.1016/j.jaut.2010.01.002 PMID 20138735
    Consulter

  • Cutting edge: genetic characterization of IFN-producing killer dendritic cells

    Fanny Guimont-Desrochers, Zachary John Cappello, Miguel Chagnon, Marcia McDuffie , Sylvie Lesage
    DOI 10.4049/jimmunol.0803969 PMID 19380763
    Consulter

  • Absence of CD47 in vivo influences thymic dendritic cell subset proportions but not negative selection of thymocytes

    Fanny Guimont-Desrochers, Claudine Beauchamp, Geneviève Chabot-Roy, Véronique Dugas, Erin E Hillhouse, Julie Dusseault, Geneviève Langlois, Patrick Gautier-Ethier, Jinane Darwiche, Marika Sarfati , Sylvie Lesage
    DOI 10.1093/intimm/dxn135 PMID 19147837
    Consulter

  • Cutting edge: CD47 controls the in vivo proliferation and homeostasis of peripheral CD4+ CD25+ Foxp3+ regulatory T cells that express CD103

    Vu Quang Van, Jinane Darwiche, Marianne Raymond , Sylvie Lesage , Salim Bouguermouh, Manuel Rubio, Marika Sarfati
    DOI 10.4049/jimmunol.181.8.5204 PMID 18832672
    Consulter

  • Expression of the self-marker CD47 on dendritic cells governs their trafficking to secondary lymphoid organs

    Vu Quang Van , Sylvie Lesage , Salim Bouguermouh, Patrick Gautier, Manuel Rubio, Martin Levesque, Sébastien Nguyen, Laurent Galibert, Marika Sarfati
    DOI 10.1038/sj.emboj.7601415 PMID 17093498
    Consulter

  • Genetic lesions in T-cell tolerance and thresholds for autoimmunity

    Adrian Liston , Sylvie Lesage , Daniel H D Gray, Richard L Boyd, Christopher C Goodnow
    DOI 10.1111/j.0105-2896.2005.00253.x PMID 15790352
    Consulter

  • Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim

    Adrian Liston , Sylvie Lesage , Daniel H D Gray, Lorraine A O'Reilly, Andreas Strasser, Aude M Fahrer, Richard L Boyd, Judith Wilson, Alan G Baxter, Elena M Gallo, Gerald R Crabtree, Kaiman Peng, Susan R Wilson, Christopher C Goodnow
    DOI 10.1016/j.immuni.2004.10.014 PMID 15589170
    Consulter

  • Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity

    Adrian Liston, Daniel H D Gray , Sylvie Lesage , Anne L Fletcher, Judith Wilson, Kylie E Webster, Hamish S Scott, Richard L Boyd, Leena Peltonen, Christopher C Goodnow
    DOI 10.1084/jem.20040581 PMID 15492124
    Consulter

  • The role of endoplasmic reticulum stress in nonimmune diabetes: NOD.k iHEL, a novel model of beta cell death

    L Socha, D Silva , Sylvie Lesage , C Goodnow, N Petrovsky
    DOI 10.1196/annals.1288.022 PMID 14679055
    Consulter

  • Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis

    Jesse E Jun, Lauren E Wilson, Carola G Vinuesa , Sylvie Lesage , Mathieu Blery, Lisa A Miosge, Matthew C Cook, Edyta M Kucharska, Hiromitsu Hara, Josef M Penninger, Heather Domashenz, Nancy A Hong, Richard J Glynne, Keats A Nelms, Christopher C Goodnow
    DOI 10.1016/s1074-7613(03)00141-9 PMID 12818157
    Consulter

  • A cell death pathway induced by antibody-mediated cross-linking of CD45 on lymphocytes

    Ann-Muriel Steff, Marylène Fortin, Fabianne Philippoussis , Sylvie Lesage , Chantal Arguin, Pauline Johnson, Patrice Hugo
    DOI 10.1615/critrevimmunol.v23.i56.40 PMID 15030310
    Consulter

  • T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: the soluble form is more effective than the membrane-bound form

    Meifen Zhang, Melanie S Vacchio, Barbara P Vistica , Sylvie Lesage , Charles E Egwuagu, Cheng-Rong Yu, Monique P Gelderman, Michael C Kennedy, Eric F Wawrousek, Igal Gery
    DOI 10.4049/jimmunol.170.8.3954 PMID 12682222
    Consulter

  • Aire regulates negative selection of organ-specific T cells

    Adrian Liston , Sylvie Lesage , Judith Wilson, Leena Peltonen, Christopher C Goodnow
    DOI 10.1038/ni906 PMID 12612579
    Consulter

  • Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes

    Sylvie Lesage , Suzanne B Hartley, Srinivas Akkaraju, Judith Wilson, Michelle Townsend, Christopher C Goodnow
    DOI 10.1084/jem.20020735 PMID 12417628
    Consulter

  • Organ-specific autoimmune disease: a deficiency of tolerogenic stimulation

    Sylvie Lesage , Christopher C Goodnow
    DOI 10.1084/jem.194.5.f31 PMID 11535640
    Consulter

  • Inhibitory effects of T-cell stimulation and co-stimulation observed at high concentrations of plate-bound antibodies

    Sylvie Lesage , Josée Charron, Patrice Hugo
    DOI 10.1016/s0022-1759(01)00415-x PMID 11470283
    Consulter

  • Thymic Selection Generates T Cells Expressing Self-Reactive TCRs in the Absence of CD45. 2000

    Sébastien Trop, Josée Charron, Chantal Arguin , Sylvie Lesage , Patrice Hugo
    DOI 10.4049/jimmunol.165.6.3073 PMID 10975818
    Consulter

  • CD4+ CD8+ thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway

    Sylvie Lesage , A M Steff, F Philippoussis, M Pagé, S Trop, V Mateo, P Hugo
    PMID 9366400
    Consulter

  • Specific activation of the cysteine protease CPP32 during the negative selection of T cells in the thymus

    Antoine Alam, Michel Y Braun, Franca Hartgers , Sylvie Lesage , Luchino Cohen, Patrice Hugo, François Denis, Rafick-Pierre Sékaly
    DOI 10.1084/jem.186.9.1503 PMID 9348308
    Consulter

  • Antagonism between Nur77 and glucocorticoid receptor for control of transcription

    Alexandre Philips, Mario Maira, Alaka Mullick, Michel Chamberland , Sylvie Lesage , Patrice Hugo, Jacques Drouin
    DOI 10.1128/MCB.17.10.5952 PMID 9315653
    Consulter

  • Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells

    Alexandre Philips , Sylvie Lesage , Rock Gingras, Mario-Hernan Maira, Yves Gauthier, Patrice Hugo, Jacques Drouin
    DOI 10.1128/MCB.17.10.5946 PMID 9315652
    Consulter

  • Induction of thymocyte deletion by purified single peptide/major histocompatibility complex ligands

    Sylvie Lesage , J Charron, G Winslow, P Hugo
    PMID 9278291
    Consulter