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Centre intégré universitaire de santé
et de services sociaux de l'Est-de-l'Île-de-Montréal

Centre intégré universitaire de santé et de services sociaux de l'Est-de-l'Île-de-Montréal

Christopher E. Rudd, Ph. D.

Chris Rudd

Chercheur, Professeur titulaire

L'équipe de l’IHOT

Chercheur

Contact

Tél. : 514 252-3400, poste 5878

En plus de son titre de professeur titulaire à l’Université de Montréal, Christopher E. Rudd est professeur auxiliaire au département de médecine de l'Université McGill. Les recherches du Prof. Rudd portent sur les mécanismes de signalisation contrôlant la fonction immunitaire des lymphocytes T et son application au traitement du cancer et de l'infection.

 

  • Directeur de l'unité de recherche en Signalisation cellulaire en immunothérapie du Centre de recherche HMR
  • Membre du Comité de direction de l’IHOT
  • Entrée en poste à l’Hôpital Maisonneuve-Rosemont : 2016

 

Formation :

  • Stage postdoctoral : Dana-Farber Cancer Institute, Université Harvard, Boston (États-Unis), 1985 à 1987
  • Doctorat : Ph. D (1980-1985) et D. Sc. (1999) : University College de Londres (Angleterre)

 

Honneurs :

  • Fellow de la Royal Society of Pathologists (FRCPath)
  • Membre de la Société royale du Canada (FRSC)

Découvrez ses publications

  • The identification of a SARs-CoV2 S2 protein derived peptide with super-antigen-like stimulatory properties on T-cells

    Tu TH, Bennani FE, Masroori N, Liu C, Nemati A, Rozza N, Grunbaum AM, Kremer R, Milhalcioiu C , Denis-Claude Roy , Chris Rudd
    DOI 10.1038/s42003-024-07350-8 PMID 39762551
    Consulter

  • PD-1 endocytosis unleashes the cytolytic potential of checkpoint blockade in tumor immunity

    Elham Ben Saad, Andres Oroya, Nikhil Ponnoor Anto, Meriem Bachais , Chris Rudd
    DOI 10.1016/j.celrep.2024.114907 PMID 39471174
    Consulter

  • Decreased progenitor TCF1 + T-cells correlate with COVID-19 disease severity

    Thai Hien Tu, Ami Grunbaum, François Santinon, Alexandra Kazanova, Nicholas Rozza, Richard Kremer, Catalin Mihalcioiu , Chris Rudd
    DOI 10.1038/s42003-024-05922-2 PMID 38702425
    Consulter

  • Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses

    Fan Huang, Christophe Gonçalves, Margarita Bartish, Joelle Rémy-Sarrazin, Mark E Issa, Brendan Cordeiro, Qianyu Guo, Audrey Emond, Mikhael Attias, William Yang, Dany Plourde, Jie Su , Marina Godoy Gimeno, Yao Zhan, Alba Galán, Tomasz Rzymski, Milena Mazan, Magdalena Masiejczyk, Jacek Faber, Elie Khoury, Alexandre Benoit, Natascha Gagnon, David Dankort, Fabrice Journe , Ghanem E Ghanem, Connie M Krawczyk, H Uri Saragovi, Ciriaco A Piccirillo, Nahum Sonenberg, Ivan Topisirovic , Chris Rudd , Wilson H Miller Jr, Sonia V Del Rincón
    DOI 10.1172/JCI181575 PMID 38690739
    Consulter

  • The many faceted role of glycogen synthase kinase-3 (GSK-3) in T cells and cancer immunotherapy

    Aurora Rivas Crespo, Silvia Guil Luna, Bastien Moës, Antonio Rodriguez , Chris Rudd
    DOI 10.46439/cancerbiology.5.058 PMID 38813058
    Consulter

  • Author Correction: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

    Yu-Hwa Huang, Chen Zhu, Yasuyuki Kondo, Ana C Anderson, Amit Gandhi, Andrew Russell, Stephanie K Dougan, Britt-Sabina Petersen, Espen Melum , Thomas Pertel, Kiera L Clayton, Monika Raab, Qiang Chen, Nicole Beauchemin, Paul J Yazaki, Michal Pyzik, Mario A Ostrowski, Jonathan N Glickman , Chris Rudd , Hidde L Ploegh, Andre Franke, Gregory A Petsko, Vijay K Kuchroo, Richard S Blumberg
    DOI 10.1038/s41586-024-07164-y PMID 38336833
    Consulter

  • Stuart Schlossman (1935-2023)

    Chris Rudd
    DOI 10.1038/s41590-023-01707-7 PMID 38168960
    Consulter

  • Clinical significance of glycogen synthase kinase 3 (GSK-3) expression and tumor budding grade in colorectal cancer: Implications for targeted therapy

    Silvia Guil-Luna, Aurora Rivas-Crespo, Carmen Navarrete-Sirvent, Ana Mantrana, Alejandra Pera, Rafael Mena-Osuna, Marta Toledano-Fonseca, María Victoria García-Ortíz , Carlos Villar, Maria Teresa Sánchez-Montero, Janna Krueger, Francisco Javier Medina-Fernández, Juan De La Haba-Rodríguez, Auxiliadora Gómez-España, Enrique Aranda , Chris Rudd , Antonio Rodríguez-Ariza
    DOI 10.1016/j.biopha.2023.115592 PMID 37778272
    Consulter

  • CD8+ T cell killing of MHC class I-deficient tumors

    Chris Rudd
    DOI 10.1038/s43018-023-00606-y PMID 37537302
    Consulter

  • Targeting EGFR, RSK1, RAF1, PARP2 and LIN28B for several cancer type therapies with newly synthesized pyrazole derivatives via a computational study

    Fatima Ezzahra Bennani, Latifa Doudach, Khalid Karrouchi, Abdelilah Tarib , Chris Rudd , M'hammed Ansar, My El Abbes Faouzi
    DOI 10.1080/07391102.2022.2064915 PMID 35442150
    Consulter

  • Targeting EGFR, RSK1, RAF1, PARP2 and LIN28B for several cancer type therapies with newly synthesized pyrazole derivatives via a computational study

    Fatima Ezzahra Bennani, Latifa Doudach, Khalid Karrouchi, Abdelilah Tarib , Chris Rudd , M'hammed Ansar, My El Abbes Faouzi
    DOI 10.1080/07391102.2022.2064915 PMID 35442150
    Consulter

  • Multi-functional adaptor SKAP1: regulator of integrin activation, the stop-signal, and the proliferation of T cells

    Chen Liu, Monika Raab, Yirui Gui , Chris Rudd
    DOI 10.3389/fimmu.2023.1192838 PMID 37325633
    Consulter

  • Blasts in context: the impact of the immune environment on acute myeloid leukemia prognosis and treatment

    Yasmina Serroukh , Josée Hébert , Lambert Busque , François Mercier , Chris Rudd , Sarit Assouline , Sylvie Lachance , Jean-Sébastien Delisle
    DOI 10.1016/j.blre.2022.100991 PMID 35941029
    Consulter

  • Direct AKT activation in tumor-infiltrating lymphocytes markedly increases interferon-γ (IFN-γ) for the regression of tumors resistant to PD-1 checkpoint blockade

    François Santinon 1 2, Bennani Fatima Ezzahra 2, Meriem Bachais 1 2, Alain Sarabia Pacis , Chris Rudd
    DOI 10.1038/s41598-022-23016-z PMID 36323740
    Consulter

  • Direct AKT activation in tumor-infiltrating lymphocytes markedly increases interferon-γ (IFN-γ) for the regression of tumors resistant to PD-1 checkpoint blockade

    François Santinon, Bennani Fatima Ezzahra, Meriem Bachais, Alain Sarabia Pacis , Chris Rudd
    DOI 10.1038/s41598-022-23016-z PMID 36323740
    Consulter

  • In Silico Identification of Promising New Pyrazole Derivative-Based Small Molecules for Modulating CRMP2, C-RAF, CYP17, VEGFR, C-KIT, and HDAC-Application towards Cancer Therapeutics

    Fatima Ezzahra Bennani, Khalid Karrouchi, Latifa Doudach, Mario Scrima, Noor Rahman, Luca Rastrelli, Trina Ekawati Tallei , Chris Rudd , My El Abbes Faouzi, M'hammed Ansar
    DOI 10.3390/cimb44110361 PMID 36354673
    Consulter

  • Mechanisms orchestrating the enzymatic activity and cellular functions of deubiquitinases

    Benjamin Estavoyer, Clémence Messmer, Mohamed Echbicheb , Chris Rudd , Eric Milot, El Bachir Affar
    DOI 10.1016/j.jbc.2022.102198 PMID 35764170
    Consulter

  • Design and prediction of novel pyrazole derivatives as potential anti-cancer compounds based on 2D-2D-QSAR study against PC-3, B16F10, K562, MDA-MB-231, A2780, ACHN and NUGC cancer cell lines

    Fatima Ezzahra Bennani, Latifa Doudach, Khalid Karrouchi, Youssef El Rhayam , Chris Rudd , M'hammed Ansar, My El Abbes Faouzi
    DOI 10.1016/j.heliyon.2022.e10003 PMID 35965973
    Consulter

  • Lithium salts as a treatment for COVID-19: Pre-clinical outcomes

    O Soriano-Torres, E Noa Romero, N L González Sosa, J M Enríquez Puertas, A Fragas Quintero, M García Montero, D Martín Alfonso, Y Infante Hernández, M Lastre , L Rodríguez-Pérez, Y Borrego, V E González, I G Vega, R Ramos Pupo, L M Reyes, M T Zumeta Dubé, Amaro Hernández, I García de la Rosa, A Minguez Suárez , L A Alarcón Camejo, M Rodríguez, R Oliva Hernández , Chris Rudd , O Pérez
    DOI 10.1016/j.biopha.2022.112872 PMID 35364381
    Consulter

  • Editorial: T-Cell Signaling Networks in Health and Disease

    Chris Rudd , Isabel Merida, William Hawse
    DOI 10.3389/fimmu.2022.875580 PMID 35464446
    Consulter

  • Effective chimeric antigen receptor T cells against SARS-CoV-2

    Xueyang Guo, Alexandra Kazanova, Stephanie Thurmond, H Uri Saragovi , Chris Rudd
    DOI 10.1016/j.isci.2021.103295 PMID 34693218
    Consulter

  • Hydroxychloroquine (HCQ) decreases the benefit of anti-PD-1 immune checkpoint blockade in tumor immunotherapy

    Janna Krueger, Francois Santinon, Alexandra Kazanova, Mark E. Issa, Bruno Larrivee, Richard Kremer, Catalin Milhalcioiu , Chris Rudd
    DOI 10.1371/journal.pone.0251731 PMID 34181666
    Consulter

  • B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling

    Sadiye Amcaoglu Rieder, Jingya Wang, Natalie White, Ariful Qadri, Catherine Menard, Geoffrey Stephens, Jodi L Karnell , Chris Rudd , Roland Kolbeck
    DOI 10.1038/s41423-020-0361-7 PMID 32005952
    Consulter

  • Programmed cell death 1 ligand (PD-L1) on T cells generates Treg suppression from memory

    Alexandra Kazanova , Chris Rudd
    DOI 10.1371/journal.pbio.3001272 PMID 34010274
    Consulter

  • Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection

    Lynette Steele, Aarren J Mannion, Gary Shaw, Kenneth A Maclennan, Graham P Cook , Chris Rudd , Alison Taylor
    DOI 10.1016/j.isci.2021.102555 PMID 34142056
    Consulter

  • Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection

    Lynette Steele, Aarren J Mannion, Gary Shaw, Kenneth A Maclennan, Graham P Cook , Chris Rudd , Alison Taylor
    DOI 10.1016/j.isci.2021.102555 PMID 34142056
    Consulter

  • Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses

    Fan Huang, Christophe Gonçalves, Margarita Bartish, Joelle Rémy-Sarrazin, Mark E Issa, Brendan Cordeiro, Qianyu Guo, Audrey Emond, Mikhael Attias, William Yang, Dany Plourde, Jie Su, Marina Godoy Gimeno, Yao Zhan , Alba Galán, Tomasz Rzymski, Milena Mazan, Magdalena Masiejczyk, Jacek Faber, Elie Khoury, Alexandre Benoit, Natascha Gagnon, David Dankort, Fabrice Journe , Ghanem E Ghanem, Connie M Krawczyk, H Uri Saragovi, Ciriaco A Piccirillo, Nahum Sonenberg, Ivan Topisirovic , Chris Rudd , Wilson H Miller Jr, Sonia V Del Rincón
    DOI 10.1172/JCI140752 PMID 33690225
    Consulter

  • How the Discovery of the CD4/CD8-p56lck Complexes Changed Immunology and Immunotherapy

    Chris Rudd
    DOI 10.3389/fcell.2021.626095 PMID 33791292
    Consulter

  • Glycogen Synthase Kinase-3 (GSK-3) Regulation of Inhibitory Coreceptor Expression in T-cell Immunity

    Mark E Issa , Chris Rudd
    DOI 10.33696/immunology.3.115 PMID 35693319
    Consulter

  • Commentary: Does Lithium Deserve a Place in the Treatment Against COVID-19? A Preliminary Observational Study in Six Patients, Case Report

    Chris Rudd
    DOI 10.3389/fphar.2020.613734 PMID 33390999
    Consulter

  • Hydroxychloroquine (HCQ) reverses anti-PD-1 immune murine checkpoint blockade: TCF1 as a marker in humans for COVID-19 and HCQ therapy

    Janna Krueger, Francois Santinon, Alexandra Kazanova, Mark Issa, Bruno Larrivee, Catalin Milhalcioiu , Chris Rudd
    DOI 10.1101/2020.09.29.20193110
    Consulter

  • GSK-3 Inhibition as a Therapeutic Approach Against SARs CoV2: Dual Benefit of Inhibiting Viral Replication While Potentiating the Immune Response

    Chris Rudd
    DOI 10.3389/fimmu.2020.01638 PMID 32695123
    Consulter

  • Glycogen synthase kinase 3 (GSK-3) controls T-cell motility and interactions with antigen presenting cells

    Alison Taylor , Chris Rudd
    DOI 10.1186/s13104-020-04971-0 PMID 32188506
    Consulter

  • Inhibition of Glycogen Synthase Kinase 3 (GSK-3) synergizes with anti-PD-1 by potentiating tumor-infiltrated CD8+T-cells

    Krueger J., Taylor A., Kazanova A., Jeidane S., Motta V., Watson I , Chris Rudd
    DOI 10.1158/2326-6074.TUMIMM19-A59
    Consulter

  • GSK-3 inhibition down-regulates inhibitory co- receptor LAG-3 on CD4 and CD8+ T-cells for enhanced anti-tumor immunity

    Chris Rudd , Alison Taylor
    Consulter

  • GSK-3 inactivation reverses T-cell exhaustion

    Kazanova A., Krueger A., Thai H., Labrecque N. , Chris Rudd
    Consulter

  • Ubc9 Interacts with and SUMOylates the TCR Adaptor SLP-76 for NFAT Transcription in T Cells

    Yiwei Xiong, Yulan Yi, Yan Wang, Naiqi Yang , Chris Rudd , Hebin Liu
    DOI 10.4049/jimmunol.1900556 PMID 31666306
    Consulter

  • Small Molecule Inhibition of Glycogen Synthase Kinase-3 in Cancer Immunotherapy

    Alison Taylor , Chris Rudd
    DOI 10.1007/978-3-030-22254-3_17 PMID 31576552
    Consulter

  • GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity

    Youg Raj Thaker, Monika Raab, Klaus Strebhardt , Chris Rudd
    DOI 10.1038/s41467-019-12544-4 PMID 31641113
    Consulter

  • Immune adaptor SKAP1 acts a scaffold for Polo-like kinase 1 (PLK1) for the optimal cell cycling of T-cells

    Monika Raab, Klaus Strebhardt , Chris Rudd
    DOI 10.1038/s41598-019-45627-9 PMID 31320682
    Consulter

  • Commentary: Small Molecule Inhibition of PD-1 Transcription is an Effective Alternative to Antibody Blockade in Cancer Therapy

    Alison Taylor , Chris Rudd
    DOI 10.29245/2578-3009/2019/1.1167 PMID 31111120
    Consulter

  • Glycogen synthase 3 (GSK-3) regulation of PD-1 expression and and its therapeutic implications

    Janna Krueger , Chris Rudd , Alison Taylor
    DOI 10.1016/j.smim.2019.101295 PMID 31604533
    Consulter

  • Advances in T-cell co-receptor biology and cancer immunotherapy

    Chris Rudd
    DOI 10.1016/j.smim.2019.101281 PMID 31604538
    Consulter

  • SKAP1 involvement in post-ligand binding T cell adhesion mediated by the α4β1integrin.

    Isern de Val, S., Sevilla-Movilla, S., Arellano-Sanchez, M, Deianira Dattoli, S., , Chris Rudd , Teixid, J
    Consulter

  • Immune adaptor protein SKAP1 (SKAP-55) forms homodimers as mediated by the N-terminal region

    Monika Raab, Klaus Strebhardt , Chris Rudd
    DOI 10.1186/s13104-018-3976-3 PMID 30522503
    Consulter

  • CTLA-4 and PD-1 Control of T-Cell Motility and Migration: Implications for Tumor Immunotherapy

    Monika C Brunner-Weinzierl , Chris Rudd
    DOI 10.3389/fimmu.2018.02737 PMID 30542345
    Consulter

  • Inhibition of glycogen synthase kinase 3 (GSK-3) is an effective alternative to anti-PD-1 in cancer immunotherapy

    Taylor A, Rothstein D , Chris Rudd
    Consulter

  • Glycogen Synthase Kinase 3 Inactivation Compensates for the Lack of CD28 in the Priming of CD8+ Cytotoxic T-Cells: Implications for anti-PD-1 Immunotherapy

    Alison Taylor , Chris Rudd
    DOI 10.3389/fimmu.2017.01653 PMID 29312284
    Consulter

  • LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation

    Monika Raab, Yuning Lu, Karsten Kohler, Xin Smith, Klaus Strebhardt , Chris Rudd
    DOI 10.1038/ncomms16001 PMID 28699640
    Consulter

  • Two Strings in One Bow: PD-1 Negatively Regulates via Co-receptor CD28 on T Cells

    Janna Krueger , Chris Rudd
    DOI 10.1016/j.immuni.2017.04.003 PMID 28423334
    Consulter

  • Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines

    Youg R Thaker, Asha Recino, Monika Raab, Asma Jabeen, Maja Wallberg, Nelson Fernandez , Chris Rudd
    DOI 10.1074/jbc.M116.759555 PMID 28188290
    Consulter

  • Identification of a new T-cell regulator

    Thaker YR, Fernandez N , Chris Rudd
    Consulter

  • SHP-1 Acts as a Key Regulator of Alloresponses by Modulating LFA-1-Mediated Adhesion in Primary Murine T Cells

    Martin G Sauer, Jessica Herbst, Ulf Diekmann , Chris Rudd , Christian Kardinal
    DOI 10.1128/MCB.00294-16 PMID 27697866
    Consulter

  • Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

    Yu-Hwa Huang, Chen Zhu, Yasuyuki Kondo, Ana C Anderson, Amit Gandhi, Andrew Russell, Stephanie K Dougan, Britt-Sabina Petersen, Espen Melum, Thomas Pertel, Kiera L Clayton, Monika Raab, Qiang Chen, Nicole Beauchemin, Paul J Yazaki, Michal Pyzik, Mario A O , Chris Rudd , Hidde L Ploegh, Andre Franke, Gregory A Petsko, Vijay K Kuchroo, Richard S Blumberg
    DOI 10.1038/nature17421 PMID 26982724
    Consulter

  • T-cell immune adaptor SKAP1 regulates the induction of collagen-induced arthritis in mice

    Xin Smith, Alison Taylor , Chris Rudd
    DOI 10.1016/j.imlet.2016.04.007 PMID 27181093
    Consulter

  • CD8+ Effector T Cell Migration to Pancreatic Islet Grafts Is Dependent on Cognate Antigen Presentation by Donor Graft Cells

    Qianqian Zhang, Hehua Dai, Karim M Yatim, Khodor Abou-Daya, Amanda L Williams, Martin H Oberbarnscheidt, Geoffrey Camirand , Chris Rudd , Fadi G Lakkis
    DOI 10.4049/jimmunol.1600832 PMID 27357151
    Consulter

  • Non-cleavable talin rescues defect in the T-cell conjugation of T-cells deficient in the immune adaptor SKAP1

    Daina Lim, Yuning Lu , Chris Rudd
    DOI 10.1016/j.imlet.2016.02.004 PMID 26905930
    Consulter

  • Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses

    Alison Taylor, James A Harker, Kittiphat Chanthong, Philip G Stevenson, Elina I Zuniga , Chris Rudd
    DOI 10.1016/j.immuni.2016.01.018 PMID 26885856
    Consulter

  • Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand

    Hong-Sheng Lim, Shaun-Paul Cordoba, Omer Dushek, Jesse Goyette, Alison Taylor , Chris Rudd , P Anton van der Merwe
    DOI 10.4049/jimmunol.1500707 PMID 26500347
    Consulter