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Centre intégré universitaire de santé
et de services sociaux de l'Est-de-l'Île-de-Montréal

Centre intégré universitaire de santé et de services sociaux de l'Est-de-l'Île-de-Montréal

Denis-Claude Roy, M.D.

Denis-Claude Roy

Hématologue-greffeur, Professeur titulaire

L'équipe de l’IHOT

Chercheur-clinicien

Contact

Tél. : 514 252-3400, poste 5503

Précurseur dans le domaine de la thérapie cellulaire, Dr Denis Claude Roy a pour principaux champs d’intérêt la greffe hématopoïétique autologue et allogénique, la maladie du greffon contre l’hôte (GVHD) ainsi que la thérapie cellulaire, incluant les cellules souches en médecine régénératrice oculaire et cardiaque.

 

  • Membre fondateur et directeur de l'Institut universitaire d'hématologie-oncologie et de thérapie cellulaire (IHOT)
  • Directeur du CETC (Centre d’excellence en thérapie cellulaire) HMR
  • Directeur de l'unité de recherche en Thérapie cellulaire du Centre de recherche HMR
  • Membre fondateur et directeur scientifique Centre C3i (commercialisation de l’immunothérapie du cancer)
  • Membre fondateur et directeur général, CellCAN (Réseau canadien de médecine régénératrice et de thérapie cellulaire)
  • Entrée en poste à l’Hôpital Maisonneuve-Rosemont : 1990

 

Formation :

  • Fellowship en immunologie tumorale : Dana-Farber Cancer Institute de l'Université Harvard, Boston (États-Unis), 1987-1990
  • Résidences en médecine interne et hématologie : Université de Montréal (Canada), 1983-1987
  • Doctorat en médecine : Université de Montréal (Canada), 1977-1982

 

Découvrez ses publications

  • Improved outcomes of UM171-expanded cord blood transplantation compared with other graft sources: real-world evidence

    Sandra Cohen , Nadia Bambace , Imran Ahmad , Jean Roy , Xiaoying Tang, Mei-Jie Zhang, Linda Burns, Frédéric Barabé , Léa Bernard , Jean-Sébastien Delisle , Thomas Kiss , Sylvie Lachance , Denis-Claude Roy , Olivier Veilleux , Guy Sauvageau
    DOI 10.1182/bloodadvances.2023010599 PMID 37467030
    Consulter
  • Impact of Implementing a Bendamustine-Based Conditioning Regimen on Outcomes of Autologous Stem Cell Transplantation in Lymphoma while Novel Cellular Therapies Emerge

    Sylvie Lachance , Alex Bourguignon, Josie-Anne Boisjoly, Philippe Bouchard , Imran Ahmad , Nadia Bambace , Léa Bernard , Sandra Cohen , Jean-Sébastien Delisle , Isabelle Fleury , Thomas Kiss , Luigina Mollica , Denis-Claude Roy , Guy Sauvageau , Olivier Veilleux , Justine Zehr, Miguel Chagnon , Jean Roy
    DOI 10.1016/j.jtct.2022.10.003 PMID 36243319
    Consulter
  • Bortezomib Maintenance After Allogeneic Transplantation in Newly Diagnosed Myeloma Patients Results in Decreased Incidence and Severity of Chronic GVHD

    DOI 10.1016/j.jtct.2022.10.022 PMID 36334654
    Consulter
  • Donor Age and Non-Relapse Mortality: Study of Their Association after HLA-Matched Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome

    DOI 10.3390/curroncol29080470 PMID 36005208
    Consulter
  • Two types of human TCR differentially regulate reactivity to self and non-self antigens

    Assya Trofimov, Philippe Brouillard, Jean-David Larouche, Jonathan Séguin, Jean-Philippe Laverdure, Ann Brasey, Gregory Ehx , Denis-Claude Roy , Lambert Busque , Sylvie Lachance , Sébastien Lemieux, Claude Perreault
    DOI 10.1016/j.isci.2022.104968 PMID 36111255
    Consulter
  • Negative Regulation of Zap70 by Lck Forms the Mechanistic Basis of Differential Expression in CD4 and CD8 T Cells

    Hassan Damen, Christian Tebid, Melissa Viens , Denis-Claude Roy , Vibhuti P Dave
    DOI 10.3389/fimmu.2022.935367 PMID 35860252
    Consulter
  • Real-World Outcomes of Autologous and Allogeneic Hematopoietic Stem Cell Transplantation for Relapsed/Refractory Hodgkin Lymphoma in the Era of Novel Therapies: A Canadian Perspective

    DOI 10.1016/j.jtct.2021.12.005 PMID 34954149
    Consulter
  • Outcomes in newly diagnosed young or high-risk myeloma patients receiving tandem autologous/allogeneic transplant followed by bortezomib maintenance: a phase II study

    Richard LeBlanc , Imran Ahmad , Rafik Terra, Jean-Samuel Boudreault, David Ogez, Kristopher Lamore , Jean-Sébastien Delisle , Nadia Bambace , Léa Bernard , Sandra Cohen , Thomas Kiss , Sylvie Lachance , Séverine Landais, Émilie Lemieux-Blanchard , Guy Sauvageau , Michael Sebag , Denis-Claude Roy , Jean Roy
    DOI 10.1038/s41409-021-01532-2 PMID 34845367
    Consulter
  • UM171-Expanded Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections

    Maude Dumont-Lagacé, Qi Li , Mégane Tanguay , Jalila Chagraoui, Tibila Kientega, Guillaume B Cardin, Ann Brasey, Assya Trofimov, Cédric Carli , Imran Ahmad , Nadia M Bambace , Léa Bernard , Thomas Kiss , Jean Roy , Denis-Claude Roy , Sébastien Lemieux, Claude Perreault, Francis Rodier, Simon Frédéric Dufresne , Lambert Busque , Sylvie Lachance , Guy Sauvageau , Sandra Cohen , Jean-Sébastien Delisle
    DOI 10.1016/j.bbmt.2020.09.031 PMID 33022376
    Consulter
  • Single UM171-expanded cord blood transplant can cure severe idiopathic aplastic anemia in absence of suitable donors

    DOI 10.1111/ejh.13504 PMID 32749758
    Consulter
  • Newly diagnosed multiple myeloma patients treated with tandem auto-allogeneic stem cell transplant have better overall survival with similar outcomes at time of relapse compared to patients who received autologous transplant only

    DOI 10.1111/ctr.14099 PMID 32981146
    Consulter
  • Stigma associated with parental depression or cancer: Impact on spouse and offspring's cortisol levels and socioemotional functioning

    Sonia J Lupien , Denis-Claude Roy , Catherine Raymond, Sarah Leclaire, Nathalie Wan, Réal Labelle, Charles-Édouard Giguère, Isabelle Ouellet-Morin
    DOI 10.1017/S0954579420001431 PMID 33427165
    Consulter
  • Analysis of the COMPARE-AMI trial: First report of long-term safety of CD133+ cells

    Kevin Haddad, Brian James Potter, Alexis Matteau, François Reeves, Guy Leclerc, Alain Rivard, François Gobeil , Denis-Claude Roy , Nicolas Noiseux, Samer Mansour
    DOI 10.1016/j.ijcard.2020.06.004 PMID 32553596
    Consulter
  • Closing the system: production of viral antigen-presenting dendritic cells eliciting specific CD8+ T cell activation in fluorinated ethylene propylene cell culture bags

    Jean-Philippe Bastien, Natalie Fekete, Ariane V Beland, Marie-Paule Lachambre, Veronique Laforte, David Juncker, Vibhuti Dave , Denis-Claude Roy , Corinne A Hoesli
    DOI 10.1186/s12967-020-02543-1 PMID 33036618
    Consulter
  • ATIR101 administered after T-cell-depleted haploidentical HSCT reduces NRM and improves overall survival in acute leukemia

    Denis-Claude Roy , Irwin Walker, Johan Maertens, Philippe Lewalle, Eduardo Olavarria, Dominik Selleslag , Sylvie Lachance , Marc Buyse, Kun Wang, Jeroen Rovers, Irene Santi, Halvard Bonig, Andrew Sandler, Jurjen Velthuis, Stephan Mielke
    DOI 10.1038/s41375-020-0733-0 PMID 32047237
    Consulter
  • Persistence of Drug-Resistant Leukemic Stem Cells and Impaired NK Cell Immunity in CML Patients Depend on MIR300 Antiproliferative and PP2A-Activating Functions

    Giovannino Silvestri; Rossana Trotta; Lorenzo Stramucci; Justin J. Ellis; Jason G. Harb; Paolo Neviani; Shuzhen Wang , Ann-Kathrin Eisfeld; Christopher J. Walker; Bin Zhang; Klara Srutova; Carlo Gambacorti-Passerini; Gabriel Pineda; Catriona H. M. Jamieson; Fabio Stagno; Paolo Vigneri; Georgios Nteliopoulos; Philippa C. May; Alistair G. Reid; Ramiro Garzon , Denis-Claude Roy , Moutuaata M. Moutuou; Martin Guimond; Peter Hokland; Michael W. Deininger; Garrett Fitzgerald; Christopher Harman; Francesco Dazzi; Dragana Milojkovic; Jane F. Apperley; Guido Marcucci; Jianfei Qi , Katerina Machova Polakova; Ying Zou; Xiaoxuan Fan; Maria R. Baer; Bruno Calabretta; Danilo Perrotti
    DOI 10.1158/0008-5472.BCD-19-0039 PMID 32974613
    Consulter
  • Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1-2 safety and feasibility study

    Sandra Cohen , Jean Roy , Sylvie Lachance , Jean-Sébastien Delisle , Anne Marinier , Lambert Busque , Denis-Claude Roy , Imran Ahmad , Nadia M Bambace , Léa Bernard , Thomas Kiss , Philippe Bouchard, Pierre Caudrelier, Sévérine Landais, Fannie Larochelle, Jalila Chagraoui, Bernhard Lehnertz, Sophie Corneau, Elisa Tomellini, Jeroen J A van Kampen, Jan J Cornelissen, Maude Dumont-Lagacé, Mégane Tanguay, Qi Li , Sébastien Lemieux, Peter W Zandstra , Guy Sauvageau
    DOI 10.1016/S2352-3026(19)30202-9 PMID 31704264
    Consulter
  • Evaluation of the Impact of Autologous Hematopoietic Stem Cell Transplantation on the Quality of Life of Older Patients with Lymphoma

    DOI 10.1016/j.bbmt.2019.09.007 PMID 31521818
    Consulter
  • Clinical applications of donor lymphocyte infusion from an HLA-haploidentical donor: consensus recommendations from the Acute Leukemia Working Party of the EBMT

    Bhagirathbhai Dholaria, Bipin N Savani, Myriam Labopin, Leo Luznik, Annalisa Ruggeri, Stephan Mielke, Monzr M Al Malki, Piyanuch Kongtim, Ephraim Fuchs, Xiao-Jun Huang , Franco Locatelli, Franco Aversa, Luca Castagna, Andrea Bacigalupo, Massimo Martelli, Didier Blaise, Patrick Ben Soussan, Yolande Arnault, Rupert Handgretinger , Denis-Claude Roy , Paul O'Donnell, Asad Bashey, Scott Solomon, Rizwan Romee, Philippe Lewalle, Jorge Gayoso, Michael Maschan, Hillard M Lazarus, Karen Ballen , Sebastian Giebel, Frederic Baron, Fabio Ciceri, Jordi Esteve, Norbert-Claude Gorin, Alexandros Spyridonidis, Christoph Schmid, Stefan O Ciurea, Arnon Nagler, Mohamad Mohty
    DOI 10.3324/haematol.2019.219790 PMID 31537691
    Consulter
  • The European Society for Blood and Marrow Transplantation (EBMT) consensus recommendations for donor selection in haploidentical hematopoietic cell transplantation

    Stefan O. Ciurea, Monzr M. Al Malki, Piyanuch Kongtim, Ephraim J. Fuchs, Leo Luznik, Xiao-Jun Huang, Fabio Ciceri, Franco Locatelli, Franco Aversa, Luca Castagna, Andrea Bacigalupo, Massimo Martelli , Didier Blaise, Patrick Ben Soussan, Yolande Arnault, Rupert Handgretinger , Denis-Claude Roy , Paul V. O’Donnell, Asad Bashey, Scott Solomon, Rizwan Romee, Jorge Gayoso, Hillard M. Lazarus, Karen Ballen, Bipin N. Savani, Mohamad Mohty, Arnon Nagler
    DOI 10.1038/s41409-019-0499-z PMID 30833742
    Consulter
  • Allodepleted T-cell immunotherapy after haploidentical haematopoietic stem cell transplantation without severe acute graft-versus-host disease (GVHD) in the absence of GVHD prophylaxis

    Denis-Claude Roy , Sylvie Lachance , Sandra Cohen , Jean-Sébastien Delisle , Thomas Kiss , Guy Sauvageau , Lambert Busque , Imran Ahmad , Léa Bernard , Nadia M Bambace, Radia S Boumédine, Marie-Claude Guertin, Katayoun Rezvani, Stephan Mielke, Claude Perreault , Jean Roy
    DOI 10.1111/bjh.15970 PMID 31135970
    Consulter
  • Critical Role for TCR Signal Strength and MHC Specificity in ThPOK-Induced CD4 Helper Lineage Choice

    Nabil Zeidan, Hassan Damen , Denis-Claude Roy , Vibhuti P Dave
    DOI 10.4049/jimmunol.1801464 PMID 31036767
    Consulter
  • Correction: The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation

    Stefan O Ciurea, Kai Cao, Marcelo Fernandez-Vina, Piyanuch Kongtim, Monzr Al Malki, Ephraim Fuchs, Leo Luznik, Xiao-Jun Huang, Fabio Ciceri, Franco Locatelli , Franco Aversa, Luca Castagna, Andrea Bacigalupo, Massimo Martelli, Didier Blaise, Rupert Handgretinger , Denis-Claude Roy , Paul O'Donnell, Asad Bashey, Hillard M Lazarus, Karen Ballen, Bipin N Savani, Mohamad Mohty, Arnon Nagler
    DOI 10.1038/s41409-018-0332-0 PMID 30232413
    Consulter
  • Outcome of autologous hematopoietic stem cell transplant in older patients with B cell lymphoma when selected for fitness and chemosensitive disease

    DOI 10.1016/j.leukres.2019.01.002 PMID 30654975
    Consulter
  • Double-Negative T Cell Levels Correlate with Chronic Graft-versus-Host Disease Severity

    Erin E Hillhouse, Stéphanie Thiant, Moutuaata M Moutuou, Félix Lombard-Vadnais, Rachel Parat , Jean-Sébastien Delisle , Imran Ahmad , Denis-Claude Roy , Martin Guimond , Jean Roy , Sylvie Lesage
    DOI 10.1016/j.bbmt.2018.09.008 PMID 30244108
    Consulter
  • Proceedings From the Fourth Haploidentical Stem Cell Transplantation Symposium (HAPLO2016), San Diego, California, December 1, 2016

    Monzr M Al Malki, Richard Jones, Qing Ma, Dean Lee, Yair Reisner, Jeffrey S Miller, Peter Lang, Suradej Hongeng, Parameswaran Hari, Samuel Strober, Jianhua Yu, Richard Maziarz, Domenico Mavilio , Denis-Claude Roy , Chiara Bonini, Richard E Champlin, Ephraim J Fuchs, Stefan O Ciurea
    DOI 10.1016/j.bbmt.2018.01.008 PMID 29339270
    Consulter
  • The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation

    Stefan O. Ciurea, Kai Cao, Marcelo Fernandez-Vina, Piyanuch Kongtim, Monzr Al Malki, Ephraim Fuchs, Leo Luznik, Xiao-Jun Huang, Fabio Ciceri, Franco Locatelli, Franco Aversa, Luca Castagna , Andrea Bacigalupo, Massimo Martelli, Didier Blaise, Rupert Handgretinger , Denis-Claude Roy , Paul O’Donnell, Asad Bashey, Hillard M. Lazarus, Karen Ballen, Bipin N. Savani, Mohamad Mohty, Arnon Nagler
    DOI 10.1038/s41409-017-0062-8 PMID 29335625
    Consulter
  • Membrane permeabilizing amphiphilic peptide delivers recombinant transcription factor and CRISPR-Cas9/Cpf1 ribonucleoproteins in hard-to-modify cells

    Thomas Del'Guidice, Jean-Pascal Lepetit-Stoffaes, Louis-Jean Bordeleau, Joannie Roberge, Vanessa Théberge, Coraline Lauvaux, Xavier Barbeau, Jessica Trottier, Vibhuti Dave , Denis-Claude Roy , Bruno Gaillet, Alain Garnier, David Guay
    DOI 10.1371/journal.pone.0195558 PMID 29617431
    Consulter
  • Major vs minor histocompatibility antigens

    Denis-Claude Roy , Claude Perreault
    DOI 10.1182/blood-2016-12-754515 PMID 28183746
    Consulter
  • The IMPACT-CABG trial: A multicenter, randomized clinical trial of CD133+ stem cell therapy during coronary artery bypass grafting for ischemic cardiomyopathy

    Nicolas Noiseux, Samer Mansour, Richard Weisel, Louis-Mathieu Stevens, Shant Der Sarkissian, Katherine Tsang, Andrew M Crean, Eric Larose, Shu-Hong Li , Bernd Wintersperger, Minh Quan Vu, Ignacio Prieto, Ren-Ke Li , Denis-Claude Roy , Terrence M Yau
    DOI 10.1016/j.jtcvs.2016.07.067 PMID 27665225
    Consulter
  • Proteogenomic-based discovery of minor histocompatibility antigens with suitable features for immunotherapy of hematologic cancers

    D P Granados, A Rodenbrock, J-P Laverdure, C Côté, O Caron-Lizotte, C Carli, H Pearson, V Janelle, C Durette, E Bonneil , Denis-Claude Roy , Jean-Sébastien Delisle , S Lemieux, P Thibault, C Perreault
    DOI 10.1038/leu.2016.22 PMID 26857467
    Consulter
  • Proceedings from the Second Haploidentical Stem Cell Transplantation Symposium-Haplo2014, San Francisco, California, December 4, 2014

    Monzr M Al Malki, Mary Horowitz, Rupert Handgretinger, Wing Leung , Denis-Claude Roy , Xiao-Jun Huang, Ephraim Fuchs, Franco Locatelli, Didier Blaise, Shin Mineishi, Massimo Martelli, Jeffrey Miller, Carl June, Hui-Sheng Ai, Leo Luznik, Domenico Mavilio, Enrico Lugli, Marcel R M van den Brink, Richard E Champlin, Stefan O Ciurea
    DOI 10.1016/j.bbmt.2016.01.001 PMID 26806585
    Consulter
  • Favorable long-term outcome of patients with multiple myeloma using a frontline tandem approach with autologous and non-myeloablative allogeneic transplantation

    DOI 10.1038/bmt.2015.319 PMID 26691426
    Consulter
  • Impact of intracoronary injection of CD133+ bone marrow stem cells on coronary atherosclerotic progression in patients with STEMI: a COMPARE-AMI IVUS substudy

    Fuyu Qiu, Akiko Maehara, Ramez El Khoury, Philippe Généreux, Laura LaSalle, Gary S Mintz, Nicolas Noiseux , Denis-Claude Roy , François Gobeil, Louis-Mathieu Stevens, François Reeves, Guy Leclerc, Alain Rivard, Samer Mansour
    DOI 10.1097/MCA.0000000000000302 PMID 26340545
    Consulter
  • Early exposure to interleukin-21 limits rapidly generated anti-Epstein-Barr virus T-cell line differentiation

    Julie Orio, Cédric Carli, Valérie Janelle , Martin Giroux , Julie Taillefer, Mathieu Goupil, Manon Richaud , Denis-Claude Roy , Jean-Sébastien Delisle
    DOI 10.1016/j.jcyt.2014.12.009 PMID 25661862
    Consulter
  • CellCAN: a unique enabler of regenerative medicine and cell therapy in Canada

    Denis-Claude Roy , Anne-Marie Alarco, Rosario Isasi
    DOI 10.1089/scd.2014.0354 PMID 25457957
    Consulter
  • Harnessing the power of alloreactivity without triggering graft-versus-host disease: how non-engrafting alloreactive cellular therapy might change the landscape of acute myeloid leukemia treatment

    DOI 10.1016/j.blre.2014.08.002 PMID 25228333
    Consulter
  • Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

    Iman Fares, Jalila Chagraoui, Yves Gareau, Stéphane Gingras, Réjean Ruel, Nadine Mayotte, Elizabeth Csaszar, David J H F Knapp, Paul Miller, Mor Ngom, Suzan Imren , Denis-Claude Roy , Kori L Watts, Hans-Peter Kiem, Robert Herrington, Norman N Iscove, R Keith Humphries, Connie J Eaves , Sandra Cohen , Anne Marinier, Peter W Zandstra , Guy Sauvageau
    DOI 10.1126/science.1256337 PMID 25237102
    Consulter
  • Inability of HOXB4 to enhance self-renewal of malignant B cells: favorable profile for the expansion of autologous hematopoietic stem cells

    Marilaine Fournier, Isabelle Savoie-Rondeau, Fannie Larochelle, Mona Hassawi, Elena A Shestakova , Denis-Claude Roy , Janetta J Bijl
    DOI 10.1016/j.exphem.2014.01.011 PMID 24503485
    Consulter
  • Policy recommendations for addressing privacy challenges associated with cell-based research and interventions

    Ubaka Ogbogu, Sarah Burningham, Adam Ollenberger, Kathryn Calder, Li Du, Khaled El Emam, Robyn Hyde-Lay, Rosario Isasi, Yann Joly, Ian Kerr, Bradley Malin, Michael McDonald, Steven Penney, Gayle Piat , Denis-Claude Roy , Jeremy Sugarman, Suzanne Vercauteren, Griet Verhenneman, Lori West, Timothy Caulfield
    DOI 10.1186/1472-6939-15-7 PMID 24485220
    Consulter