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Centre intégré universitaire de santé
et de services sociaux de l'Est-de-l'Île-de-Montréal

Centre intégré universitaire de santé et de services sociaux de l'Est-de-l'Île-de-Montréal

Josée Hébert, M.D.

Josée Hébert

Hématologue, Professeure titulaire

L'équipe de l’IHOT

Chercheur-clinicien

Contact

Tél. : 514 252-3404

Site web de Leucegene

Dre Josée Hébert co-dirige le projet Leucegene, dont les objectifs sont d’identifier de nouveaux biomarqueurs et cibles thérapeutiques et de développer de nouvelles thérapies pour traiter la leucémie myéloïde aigüe.

 

  • Directrice de la Banque de cellules leucémiques du Québec (BCLQ)
  • Directrice scientifique de la plateforme de cytogénétique de la BCLQ
  • Directrice médicale du laboratoire de cytogénétique de HMR
  • Titulaire de la Chaire Industrielle-Alliance de recherche en leucémie de l'Université de Montréal
  • Membre du comité exécutif du Réseau de recherche sur le cancer, Fonds de recherche du Québec - Santé (FRQS)
  • Entrée en poste à l’Hôpital Maisonneuve-Rosemont : 2000

 

Formation :

  • Fellowship en génétique moléculaire des leucémies : Institut national de la santé et de la recherche médicale, Hôpital Saint-Louis de Paris (France), 1992-1994
  • Résidences en médecine interne et hématologie : Université de Montréal (Canada), 1986-1991
  • Doctorat en médecine : Université de Montréal (Canada), 1979-1984

Découvrez ses publications

  • Integrated drug resistance and leukemic stemness gene-expression scores predict outcomes in large cohort of over 3500 AML patients from 10 trials

    Abdelrahman H. Elsayed, Xueyuan Cao, Richard J. Marrero, Nam H. K. Nguyen, Huiyun Wu, Yonhui Ni, Raul C. Ribeiro, Herold Tobias, Peter J. Valk, François Béliveau, Guillaume Richard-Carpentier, , Josée Hébert , C. Michel Zwaan, Alan Gamis, Edward Anders Kolb, Richard Aplenc, Todd A. Alonzo, Soheil Meshinchi, Jeffrey Rubnitz, Stanley Pounds, Jatinder K. Lamba
    DOI 10.1038/s41698-024-00643-5 PMID 39090192
    Consulter

  • Genetic deletion of JAM-C in pre-leukemic cells rewires leukemic stem cell gene expression program in AML

    Julien M.P. Grenier, Céline Testut, Matthieu Bal, Florence Bardin, Maria De Grandis, Véronique Gelsi-Boyer, Julien Vernerny, Marjorie C Delahaye, Samuel Granjeaud, Christophe Zemmour, Jean-François Spinella, Triantafyllos Chavakis, Stephane JC Mancini , Jean-Marie Boher , Josée Hébert , Guy Sauvageau , Norbert Vey, Juerg Schwaller, Marie-Anne Hospital, Cyril Fauriat, Michel A Aurrand-Lions
    DOI 10.1182/bloodadvances.2023011747 PMID 38954834
    Consulter

  • Immunotherapeutic targeting of surfaceome heterogeneity in AML

    Marie-Eve Bordeleau, Éric Audemard, Arnaud Métois, Louis Theret, Véronique Lisi, Azer Farah, Jean-François Spinella, Jalila Chagraoui, Ossama Moujaber, Léo Aubert, Banafsheh Khakipoor, Laure Mallinger, Isabel Boivin, Nadine Mayotte , Azadeh Hajmirza, Éric Bonneil, François Béliveau, Sybille Pfammatter, Albert Feghaly, Geneviève Boucher, Patrick Gendron, Pierre Thibault, Frédéric Barabé, Sébastien Lemieux, Guillaume Richard-Carpentier , Josée Hébert , Vincent-Philippe Lavallée, Philippe P Roux , Guy Sauvageau
    DOI 10.1016/j.celrep.2024.114260 PMID 38838225
    Consulter

  • SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia

    Céline Moison, Deanne Gracias, Julie Schmitt, Simon Girard, Jean-François Spinella, Simon Fortier, Isabel Boivin, Rodrigo Mendoza-Sanchez, Bounkham Thavonekham , Tara MacRae, Nadine Mayotte, Eric Bonneil, Mark Wittman, James Carmichael, Réjean Ruel, Pierre Thibault , Josée Hébert , Anne Marinier , Guy Sauvageau
    DOI 10.1126/sciadv.adl4018 PMID 38517966
    Consulter

  • CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax and DT2216

    Verena Gress, Mathieu Roussy, Luc Boulianne, Mélanie Bilodeau, Sophie Cardin, Nehme El-Hachem, Véronique Lisi, Banafsheh Khakipoor, Alexandre Rouette, Azer Farah, Louis Théret, Léo Aubert, Furat Fatima, Éric Audemard, Pierre Thibault, Éric Bonneil , Jalila Chagraoui, Louise Laramée, Patrick Gendron, Loubna Jouan, Safa Jammali, Bastien Paré, Shawn M. Simpson, Thai Hoa Tran, Michel Duval, Pierre Teira , Henrique Bittencourt, Raoul Santiago, Frédéric Barabé , Guy Sauvageau , Martin A. Smith , Josée Hébert , Philippe P. Roux, Tanja A. Gruber, Vincent-Philippe Lavallée, Brian T. Wilhelm, Sonia Cellot
    DOI 10.1182/bloodadvances.2022008899 PMID 37729615
    Consulter

  • GPRC5C drives branched-chain amino acid metabolism in leukemogenesis

    Yu Wei Zhang, Talia Velasco-Hernandez, Julian Mess, Maria-Eleni Lalioti, Mari Carmen Romero-Mulero, Nadine Obier, Nikolaos Karantzelis, Jasmin Rettkowski, Katharina Schönberger , Noémie Karabacz, Karin Jäcklein, Tatsuya Morishima, Juan Luis Trincado, Paola Romecin, Alba Martinez, Hitoshi Takizawa, Khalid Shoumariyeh, Simon Renders, Robert Zeiser, Heike L. Pahl, François Béliveau , Josée Hébert , Bernhard Lehnertz , Guy Sauvageau , Pablo Menendez, Nina Cabezas-Wallscheid
    DOI 10.1182/bloodadvances.2023010460 PMID 37639313
    Consulter

  • DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML

    Jean-François Spinella, Jalila Chagraoui, Céline Moison, Vincent P. Lavallée, Isabel Boivin, Deanne Gracias, Sylvie Lavallée, Guillaume Richard Carpentier, François Beliveau , Josée Hébert , Guy Sauvageau
    DOI 10.1038/s41375-023-02107-4 PMID 38102204
    Consulter

  • Optical Genome Mapping Reveals the Complex Genetic Landscape of Myeloma

    Amélie Giguère, Isabelle Raymond-Bouchard, Vanessa Collin , Jean-Sébastien Claveau , Josée Hébert , Richard LeBlanc
    DOI 10.3390/cancers15194687 PMID 37835381
    Consulter

  • Heterogeneity in leukemia cells that escape drug-induced senescence-like state

    David Miller, Kyra Kerkhofs, Farnoosh Abbas-Aghababazadeh, Sahib Singh Madahar, Mark D. Minden , Josée Hébert , Benjamin Haibe-Kains, Mark A. Bayfield, Samuel Benchimol
    DOI 10.1038/s41419-023-06015-4 PMID 37543610
    Consulter

  • Blasts in context: the impact of the immune environment on acute myeloid leukemia prognosis and treatment

    Yasmina Serroukh , Josée Hébert , Lambert Busque , François Mercier , Chris Rudd , Sarit Assouline , Sylvie Lachance , Jean-Sébastien Delisle
    DOI 10.1016/j.blre.2022.100991 PMID 35941029
    Consulter

  • Unified gene expression signature of novel NPM1 exon 5 mutations in acute myeloid leukemia

    Véronique Lisi, Ève Blanchard, Michael Vladovsky, Éric Audemard, Albert Ferghaly, Sébastien Lemieux , Josée Hébert , Guy Sauvageau , Vincent-Philippe Lavallée
    DOI 10.1182/bloodadvances.2022007300 PMID 35849707
    Consulter

  • HMGA2 expression defines a subset of human AML with immature transcriptional signature and vulnerability to G2/M inhibition

    Céline Moison, Jean-François Spinella, Jalila Chagraoui, Vincent-Philippe Lavallée, Bernhard Lehnertz, Clarisse Thiollier, Isabel Boivin, Nadine Mayotte, Tara MacRae, Anne Marinier , Josée Hébert , Guy Sauvageau
    DOI 10.1182/bloodadvances.2021005828 PMID 35797243
    Consulter

  • CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia

    Lixiazi He, Christian Arnold, Judith Thoma, Christian Rohde, Maksim Kholmatov, Swati Garg, Cheng‐Chih Hsiao, Linda Viol, Kaiqing Zhang https://orcid.org/0000-0003-0213-6035, Rui Sun, Christina Schmidt, Maike Janssen, Tara MacRae, Karin Huber, , Josée Hébert , Guy Sauvageau , Christian Thiede , Julia Spratte, Herbert Fluhr, Gabriela Aust, Carsten Müller‐Tidow, Christof Niehrs, Gislene Pereira, Jörg Hamann, Motomu Tanaka , Judith B Zaugg, Caroline Pabst
    DOI 10.15252/emmm.202114990 PMID 35253392
    Consulter

  • Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia

    Diogo F T Veiga, Mathieu Tremblay, Bastien Gerby, Sabine Herblot, André Haman, Patrick Gendron, Sébastien Lemieux, Juan Carlos Zúñiga-Pflücker , Josée Hébert , Joseph Paul Cohen, Trang Hoang
    DOI 10.3389/fimmu.2022.867443 PMID 35401501
    Consulter

  • Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia

    Jana Krosl, Marie-Eve Bordeleau, Céline Moison, Tara MacRae, Isabel Boivin, Nadine Mayotte, Deanne Gracias, Irène Baccelli, Vincent-Philippe Lavallée, Richard Bisaillon, Bernhard Lehnertz, Rodrigo Mendoza-Sanchez, Réjean Ruel, Thierry Bertomeu , Jasmin Coulombe-Huntington, Geneviève Boucher, Nandita Noronha, Caroline Pabst, Mike Tyers, Patrick Gendron, Sébastien Lemieux, Frédéric Barabé, Anne Marinier , Josée Hébert , Guy Sauvageau
    DOI 10.1182/bloodadvances.2021006047 PMID 34731885
    Consulter

  • Epigenetic changes in human model KMT2A leukemias highlight early events during leukemogenesis

    Thomas Milan, Magalie Celton, Karine Lagacé, Élodie Roques, Safia Safa-Tahar-Henni, Eva Bresson, Anne Bergeron , Josée Hébert , Soheil Meshinchi , Sonia Cellot, Frédéric Barabé, Brian T Wilhelm
    DOI 10.3324/haematol.2020.271619 PMID 33375773
    Consulter

  • Legal and Ethical Considerations for the Design and Use of Web Portals for Researchers, Clinicians, and Patients: Scoping Literature Review

    Michael Lang, Sébastien Lemieux , Josée Hébert , Guy Sauvageau , Ma'n H Zawati
    DOI 10.2196/26450 PMID 34762055
    Consulter

  • Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes

    Grégory Ehx, Jean-David Larouche, Chantal Durette, Jean-Philippe Laverdure, Leslie Hesnard, Krystel Vincent, Marie-Pierre Hardy, Catherine Thériault, Caroline Rulleau, Joël Lanoix, Eric Bonneil, Albert Feghaly, Anca Apavaloaei , Nandita Noronha, Céline M Laumont , Jean-Sébastien Delisle , Luca Vago , Josée Hébert , Guy Sauvageau , Sébastien Lemieux, Pierre Thibault, Claude Perreault
    DOI 10.1016/j.immuni.2021.03.001 PMID 33740418
    Consulter

  • Human pluripotent stem cells identify molecular targets of trisomy 12 in chronic lymphocytic leukemia patients

    Jennifer C Reid, Diana Golubeva, Allison L Boyd, Cameron G Hollands, Charisa Henly, Luca Orlando, Andrew Leber , Josée Hébert , Fortunato Morabito, Giovanna Cutrona, Luca Agnelli, Massimo Gentile, Manlio Ferrarini, Antonino Neri, Brian Leber, Mickie Bhatia
    DOI 10.1016/j.celrep.2021.108845 PMID 33730576
    Consulter

  • Apoptotic Blocks in Primary Non-Hodgkin B Cell Lymphomas Identified by BH3 Profiling

    Ryan N Rys, Claudia M Wever, Dominique Geoffrion, Christophe Goncalves, Artin Ghassemian, Eugene Brailovski, Jeremy Ryan, Liliana Stoica , Josée Hébert , Tina Petrogiannis-Haliotis, Svetlana Dmitrienko, Saul Frenkiel, Annette Staiger, German Ott, Christian Steidl, David W Scott, Pierre Sesques, Sonia Del Rincon, Koren K Mann, Anthony Letai, Nathalie A Johnson
    DOI 10.3390/cancers13051002 PMID 33670870
    Consulter

  • Erratum: The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID

    Shiva Safavi, Ariane Larouche, Astrid Zahn, Anne-Marie Patenaude, Diana Domanska, Kiersten Dionne, Torbjørn Rognes, Felix Dingler, Seong-Kwi Kang, Yan Liu, Nathalie Johnson , Josée Hébert , Ramiro E Verdun, Cristina A Rada, Francisco Vega, Hilde Nilsen, Javier M D Noia
    DOI 10.1093/narcan/zcaa045 PMID 34316697
    Consulter

  • The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID

    Shiva Safavi, Ariane Larouche, Astrid Zahn, Anne-Marie Patenaude, Diana Domanska, Kiersten Dionne, Torbjørn Rognes, Felix Dingler, Seong-Kwi Kang, Yan Liu, Nathalie Johnson , Josée Hébert , Ramiro E Verdun, Cristina A Rada, Francisco Vega, Hilde Nilsen, Javier M Di Noia
    DOI 10.1093/narcan/zcaa019 PMID 33554121
    Consulter

  • High frequency of germline RUNX1 mutations in patients with RUNX1-mutated AML

    Laura Simon, Jean-François Spinella, Chi-Yuan Yao, Vincent-Philippe Lavallée, Isabel Boivin, Geneviève Boucher, Eric Audemard, Marie-Eve Bordeleau, Sébastien Lemieux , Josée Hébert , Guy Sauvageau
    DOI 10.1182/blood.2019003357 PMID 32315381
    Consulter

  • Cryptic recurrent ACIN1-NUTM1 fusions in non-KMT2A-rearranged infant acute lymphoblastic leukemia

    Thomas Pincez, Josette-Renée Landry, Mathieu Roussy, Loubna Jouan, Mélanie Bilodeau, Louise Laramée, Françoise Couture, Daniel Sinnett, Patrick Gendron , Josée Hébert , Luc Oligny, Alexandre Rouette, Thai H Tran, Brian T Wilhelm, Henrique Bittencourt, Sonia Cellot
    DOI 10.1002/gcc.22808 PMID 31515871
    Consulter

  • Genetic characterization of ABT-199 sensitivity in human AML

    Richard Bisaillon, Céline Moison, Clarisse Thiollier, Jana Krosl, Marie-Eve Bordeleau, Bernhard Lehnertz, Vincent-Philippe Lavallée, Tara MacRae, Nadine Mayotte , Caroline Labelle, Geneviève Boucher, Jean-François Spinella, Isabel Boivin, Giovanni D'Angelo, Sylvie Lavallée, Anne Marinier, Sébastien Lemieux , Josée Hébert , Guy Sauvageau
    DOI 10.1038/s41375-019-0485-x PMID 31300747
    Consulter

  • Cost-Effectiveness Analysis of a HMGA2 Prognostic Test for Acute Myeloid Leukemia in a Canadian Setting

    Gabriel Tremblay, Ben Rousseau, Miriam Marquis, Cyrielle Beaubois , Guy Sauvageau , Josée Hébert
    DOI 10.1007/s40258-019-00503-5 PMID 31392669
    Consulter

  • The neuropeptide receptor calcitonin receptor-like (CALCRL) is a potential therapeutic target in acute myeloid leukemia

    Linus Angenendt, Eike Bormann, Caroline Pabst, Vijay Alla, Dennis Görlich, Leonie Braun, Kim Dohlich, Christian Schwöppe, Stefan K. Bohlander, Maria Francisca Arteaga, Klaus Wethmar, Wolfgang Hartmann , Adrian Angenendt, Torsten Kessler, Rolf M. Mesters, Matthias Stelljes, Maja Rothenberg-Thurley, Karsten Spiekermann , Josée Hébert , Guy Sauvageau , Peter J. M. Valk, Bob Löwenberg, Hubert Serve, Carsten Müller-Tidow, Georg Lenz, Bernhard J. Wörmann, M. Christina Sauerland, Wolfgang Hiddemann , Wolfgang E. Berdel, Utz Krug, Klaus H. Metzeler, Jan-Henrik Mikesch, Tobias Herold, Christoph Schliemann
    DOI 10.1038/s41375-019-0505-x PMID 31182782
    Consulter

  • Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities

    Sophie Cardin, Mélanie Bilodeau, Mathieu Roussy, Léo Aubert, Thomas Milan, Loubna Jouan, Alexandre Rouette, Louise Laramée, Patrick Gendron, Jean Duchaine, Hélène Decaluwe, Jean-François Spinella, Stéphanie Mourad, Françoise Couture, Daniel Sinnett , Élie Haddad, Josette-Renée Landry, Jing Ma, R. Keith Humphries, Philippe P. Roux , Josée Hébert , Tanja A. Gruber, Brian T. Wilhelm, Sonia Cellot
    DOI 10.1182/bloodadvances.2019030981 PMID 31698461
    Consulter

  • Targeted variant detection using unaligned RNA-Seq reads

    Eric Olivier Audemard, Patrick Gendron, Albert Feghaly, Vincent-Philippe Lavallée , Josée Hébert , Guy Sauvageau , Sébastien Lemieux
    DOI 10.26508/lsa.201900336 PMID 31427380
    Consulter

  • IDH1 as a Cooperating Mutation in AML Arising in the Context of Shwachman-Diamond Syndrome

    Stéphanie Mourad, Mélanie Bilodeau, Mathieu Roussy, Louise Laramée, Luc Boulianne, Alexandre Rouette, Loubna Jouan, Patrick Gendron, Michel Duval, Pierre Teira , Josée Hébert , Henrique Bittencourt, Yves Pastore, Josette-Renée Landry, Sonia Cellot
    DOI 10.3389/fonc.2019.00772 PMID 31475115
    Consulter

  • Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML

    Swati Garg, Armando Reyes-Palomares, Lixiazi He, Anne Bergeron, Vincent-Philippe Lavallée, Sébastien Lemieux, Patrick Gendron, Christian Rohde, Jianglong Xia, Prarabdha Jagdhane, Carsten Müller-Tidow, Daniel B. Lipka, Suzan Imren, R. Keith Humphries , Claudia Waskow, Binje Vick, Irmela Jeremias, Guillaume Richard-Carpentier , Josée Hébert , Guy Sauvageau , Judith B. Zaugg, Frédéric Barabé, Caroline Pabst
    DOI 10.1182/blood.2018862383 PMID 31076446
    Consulter

  • Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia

    Irène Baccelli, Yves Gareau, Bernhard Lehnertz, Stéphane Gingras, Jean-François Spinella, Sophie Corneau, Nadine Mayotte, Simon Girard, Mélanie Frechette, Valérie Blouin-Chagnon, Koryne Leveillé, Isabel Boivin, Tara MacRae, Jana Krosl , Clarisse Thiollier, Vincent-Philippe Lavallée, Evgeny Kanshin, Thierry Bertomeu, Jasmin Coulombe-Huntington, Corinne St-Denis, Marie-Eve Bordeleau, Geneviève Boucher , Philippe P Roux, Sébastien Lemieux, Mike Tyers, Pierre Thibault , Josée Hébert , Anne Marinier , Guy Sauvageau
    DOI 10.1016/j.ccell.2019.06.003 PMID 31287994
    Consulter

  • Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition

    Céline Moison, Vincent-Philippe Lavallée, Clarisse Thiollier, Bernhard Lehnertz, Isabel Boivin, Nadine Mayotte, Yves Gareau, Mélanie Fréchette, Valérie Blouin-Chagnon , Sophie Corneau, Sylvie Lavallée, Sébastien Lemieux, Anne Marinier , Josée Hébert , Guy Sauvageau
    DOI 10.1182/bloodadvances.2018028480 PMID 30782614
    Consulter

  • The Adhesion G Protein-Coupled Receptor GPR97/ ADGRG3 Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions

    Cheng-Chih Hsiao, Tai-Ying Chu, Chia-Jung Wu, Maartje van den Biggelaar, Caroline Pabst , Josée Hébert , Taco W Kuijpers, Brendon P Scicluna, Kuan-Yu I, Tse-Ching Chen, Ines Liebscher, Jörg Hamann, Hsi-Hsien Lin
    DOI 10.3389/fimmu.2018.02830 PMID 30559745
    Consulter

  • The genomic landscape of two Burkitt lymphoma cases and derived cell lines: comparison between primary and relapse samples

    Claudia M Wever, Dominique Geoffrion, Bruno M Grande, Stephen Yu, Miguel Alcaide, Maryse Lemaire, Yasser Riazalhosseini , Josée Hébert , Christina Gavino, Donald C Vinh, Tina Petrogiannis-Haliotis, Svetlana Dmitrienko, Koren K Mann, Ryan D Morin, Nathalie A Johnson
    DOI 10.1080/10428194.2017.1413186 PMID 29295643
    Consulter

  • High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia

    Miriam Marquis, Cyrielle Beaubois, Vincent-Philippe Lavallée, Michal Abrahamowicz, Coraline Danieli, Sébastien Lemieux , Imran Ahmad , Andrew Wei, Stephen B. Ting, Shaun Fleming, Anthony Schwarer, David Grimwade, William Grey, Robert K. Hills, Paresh Vyas, Nigel Russell , Guy Sauvageau , Josée Hébert
    DOI 10.1038/s41408-018-0103-6 PMID 30061630
    Consulter

  • Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin

    Vincent-Philippe Lavallée, Jalila Chagraoui, Tara MacRae, Miriam Marquis, Arnaud Bonnefoy, Jana Krosl, Sébastien Lemieux, Anne Marinier, Caroline Pabst, Georges-Étienne Rivard , Josée Hébert , Guy Sauvageau
    DOI 10.1038/s41375-018-0069-1 PMID 29550835
    Consulter

  • GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1

    Charles Vadnais, Riyan Chen, Jennifer Fraszczak, Zhenbao Yu, Jonathan Boulais, Jordan Pinder, Daria Frank, Cyrus Khandanpour , Josée Hébert , Graham Dellaire, Jean-François Côté, Stéphane Richard, Alexandre Orthwein, Elliot Drobetsky, Tarik Möröy
    DOI 10.1038/s41467-018-03817-5 PMID 29651020
    Consulter

  • MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia

    Fiona C Brown, Eric Still, Richard P Koche, Christina Y Yim, Sumiko Takao, Paolo Cifani, Casie Reed, Shehana Gunasekera, Scott B Ficarro, Peter Romanienko, Willie Mark , Craig McCarthy, Elisa de Stanchina, Mithat Gonen, Venkatraman Seshan, Patrick Bhola, Conor O'Donnell, Barbara Spitzer, Crystal Stutzke, Vincent-Philippe Lavallée , Josée Hébert , Andrei V Krivtsov, Ari Melnick, Elisabeth M Paietta, Martin S Tallman, Anthony Letai , Guy Sauvageau , Gayle Pouliot, Ross Levine, Jarrod A Marto, Scott A Armstrong, Alex Kentsis
    DOI 10.1158/2159-8290.CD-17-1271 PMID 29431698
    Consulter

  • NUP98-BPTF gene fusion identified in primary refractory acute megakaryoblastic leukemia of infancy

    Mathieu Roussy, Mélanie Bilodeau, Loubna Jouan, Pauline Tibout, Louise Laramée, Emmanuelle Lemyre, France Léveillé, Frédérique Tihy, Sophie Cardin, Camille Sauvageau, Françoise Couture, Isabelle Louis , Aurélien Choblet, Natalie Patey, Patrick Gendron, Michel Duval, Pierre Teira , Josée Hébert , Brian T. Wilhelm, John K. Choi, Tanja A. Gruber, Henrique Bittencourt, Sonia Cellot
    DOI 10.1002/gcc.22532 PMID 29427526
    Consulter

  • Identification of novel biomarkers for MLL-translocated acute myeloid leukemia

    Karine Lagacé, Fréderic Barabé , Josée Hébert , Sonia Cellot, Brian T Wilhelm
    DOI 10.1016/j.exphem.2017.08.006 PMID 28911906
    Consulter

  • H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations

    Bernhard Lehnertz, Yu Wei Zhang, Isabel Boivin, Nadine Mayotte, Elisa Tomellini, Jalila Chagraoui, Vincent-Philippe Lavallée , Josée Hébert , Guy Sauvageau
    DOI 10.1182/blood-2017-03-774653 PMID 28855157
    Consulter

  • Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity

    Laura Simon, Vincent-Philippe Lavallée, Marie-Eve Bordeleau, Jana Krosl, Irène Baccelli, Geneviève Boucher, Bernhard Lehnertz, Jalila Chagraoui, Tara MacRae, Réjean Ruel , Yves Chantigny, Sébastien Lemieux, Anne Marinier , Josée Hébert , Guy Sauvageau
    DOI 10.1158/1078-0432.CCR-17-1259 PMID 28855357
    Consulter

  • MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets

    Sebastien Lemieux, Tobias Sargeant, David Laperrière, Houssam Ismail, Geneviève Boucher, Marieke Rozendaal, Vincent-Philippe Lavallée, Dariel Ashton-Beaucage, Brian Wilhelm , Josée Hébert , Douglas J Hilton, Sylvie Mader , Guy Sauvageau
    DOI 10.1093/nar/gkx338 PMID 28472340
    Consulter

  • AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia

    Fengbiao Zhou, Yi Liu, Christian Rohde, Cornelius Pauli, Dennis Gerloff, Marcel Köhn, Danny Misiak, Nicole Bäumer, Chunhong Cui, Stefanie Göllner, Thomas Oellerich, Hubert Serve, Maria-Paz Garcia-Cuellar, Robert Slany , Jaroslaw P. Maciejewski, Bartlomiej Przychodzen, Barbara Seliger, Hans-Ulrich Klein, Christoph Bartenhagen, Wolfgang E. Berdel, Martin Dugas, Makoto Mark Taketo, Daneyal Farouq, Schraga Schwartz, Aviv Regev , Josée Hébert , Guy Sauvageau , Caroline Pabst, Stefan Hüttelmaier, Carsten Müller-Tidow
    DOI 10.1038/ncb3563 PMID 28650479
    Consulter

  • Adhesion GPCRs in Regulating Immune Responses and Inflammation

    Hsi-Hsien Lin, Cheng-Chih Hsiao, Caroline Pabst , Josée Hébert , Torsten Schöneberg, Jörg Hamann
    DOI 10.1016/bs.ai.2017.05.005 PMID 28950945
    Consulter

  • Modeling human MLL-AF9 translocated acute myeloid leukemia from single donors reveals RET as a potential therapeutic target

    F Barabé, L Gil, M Celton, A Bergeron, V Lamontagne, É Roques, K Lagacé, A Forest, R Johnson, L Pécheux, J Simard, J Pelloux, A Bellemare-Pelletier, E Gagnon , Josée Hébert , S Cellot, B T Wilhelm
    DOI 10.1038/leu.2016.302 PMID 27780967
    Consulter

  • A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens

    I Baccelli, J Krosl, G Boucher, I Boivin, V-P Lavallée , Josée Hébert , S Lemieux, A Marinier , Guy Sauvageau
    DOI 10.1038/bcj.2017.10 PMID 28211886
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